Immune system influence on physiology

• 成果类型: Review
• 署名作者: Nahrendorf, Matthias; Ginhoux, Florent; Swirski, Filip K.
• 署名单位: Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Wurzburg; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Universite Paris Saclay; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Chinese Academy of Sciences; Shanghai Jiao Tong University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10882
• DOI: 10.1126/science.adx4380
• 发表日期: 2025-08-07
• 页码: 594-599
• 关键词: t-cells; macrophages; homeostasis; innate; gamma

摘要

The immune system's central function is to maintain homeostasis by guarding the organism against dangerous external and internal stressors. Immunity's operational toolbox contains diverse processes, such as phagocytosis, antigen recognition, cell killing, and secretion of cytokines and antibodies. Although immune cells interact with each other, they also communicate with cells typically associated with other organ systems, including the nervous, circulatory, metabolic, musculoskeletal, endocrine, and hematopoietic. This abundant cross-talk shows that immunity transcends defense and homeostasis: It is a network that participates in many physiological processes necessary for life. By accessing the circulation and inhabiting every tissue, leukocytes sense, interpret, and regulate biological processes. In this Review, we highlight recent studies that illustrate the often bidirectional and symbiotic relationships through which the immune system regulates physiology.