6761期

最新文章

• NIH weighs controversial overhaul of HIV budget AI翻译
  作者：Cohen, Jon
• Scalable emulation of protein equilibrium ensembles with generative deep learning AI翻译
  作者：Lewis, Sarah; Hempel, Tim; Jimenez-Luna, Jose; Gastegger, Michael; Xie, Yu; Foong, Andrew Y. K.; Satorras, Victor Garcia; Abdin, Osama; Veeling, Bastiaan S.; Zaporozhets, Iryna; Chen, Yaoyi; Yang, Soojung; Foster, Adam E.; Schneuing, Arne; Nigam, Jigyasa; Barbero, Federico; Stimper, Vincent; Campbell, Andrew; Yim, Jason; Lienen, Marten; Shi, Yu; Zheng, Shuxin; Schulz, Hannes; Munir, Usman; Sordillo, Roberto; Tomioka, Ryota; Clementi, Cecilia; Noe, Frank
  作者单位：Microsoft; Free University of Berlin; Rice University
  摘要：Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that emulates protein equilibrium ensembles by generating thousands of statistically independent structures per hour on a single graphics processing unit (GPU). BioEmu integrates more than 200 milliseconds of molecular dynamics (MD) simulations, static structures, and experimental protein stabilities ...
• The scent of a crowd AI翻译
  作者：Schandry, Niklas; Becker, Claude
  作者单位：University of Munich
• Climate-smart biofuel policy as a pathway to decarbonize agriculture A policy that relies on farm-specific carbon-intensity scores can promote climate-smart agricultural practices. AI翻译
  作者：Khanna, Madhu; Basso, Bruno; O'Hara, Jeff; Zilberman, David; Hochman, Gal
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Michigan State University; United States Department of Agriculture (USDA); University of California System; University of California Berkeley
• Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA AI翻译
  作者：Murphy, Lauren; Inchauspe, Jeanne; Valenzano, Giampiero; Holland, Pamela; Sousos, Nikolaos; Belnoue-Davis, Hayley L.; Li, Rong; Jooss, Natalie J.; Benlabiod, Camelia; Murphy, Eleanor; Etzioni, Zohar; Shepherd, Emelie; Denly, Lucy; Biswas, Sujata; Chen, Lin; O'Sullivan, Jennifer; Rimmer, Michael P.; Khan, Abdullah O.; Karali, Christina Simoglou; Nasreddin, Nadia; Hitchcock, Ian S.; Koupenova, Milka; Kriaucionis, Skirmantas; Hughes, Jim R.; O'Neill, Eric; Vatish, Manu; Rees, Paul; Leedham, Simon; Desborough, Michael; Mead, Adam J.; Schuster-Bockler, Benjamin; Gregory, Christopher D.; Psaila, Bethan
  作者单位：University of Oxford; University of Oxford; University of Oxford; Ludwig Institute for Cancer Research; University of Oxford; University of Edinburgh; Oxford University Hospitals NHS Foundation Trust; University of Oxford; Wellcome Centre for Human Genetics; University of York - UK; University of York - UK; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Oxford; Swansea University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in cell-free DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained a repertoire of DNA fragments mapping across the nuclear genome. We detected fetal D...
• Addressing Southeast Asia's plastic pollution AI翻译
  作者：Xayachak, Tu; Haque, Nawshad; Pramanik, Biplob Kumar
  作者单位：Royal Melbourne Institute of Technology (RMIT); Commonwealth Scientific & Industrial Research Organisation (CSIRO)
• Diffraction of helium and hydrogen atoms through single-layer graphene AI翻译
  作者：Kanitz, Carina; Buehler, Jakob; Zobac, Vladimir; Robinson, Joseph J.; Susi, Toma; Debiossac, Maxime; Brand, Christian
  作者单位：Helmholtz Association; German Aerospace Centre (DLR); University of Vienna
  摘要：Diffraction of atoms from surfaces provides detailed insights into structures, interactions, and dynamical processes. However, the method is currently limited to measurements in reflection-diffraction through materials has only been demonstrated for subatomic particles and is an outstanding challenge for atoms. In this work, we diffract helium and hydrogen atoms at kilo-electron volt energies through single-layer graphene at normal incidence. Despite the atoms' high kinetic energy as well as c...
• Correction in Science rekindles debate over Microsoft's quantum computing research AI翻译
  作者：Mann, Adam
• Trump moves to politicize decisions on science grants AI翻译
  作者：Mervis, Jeffrey
• Setting the table for immune tolerance AI翻译
  作者：Silverman, Michael; Knoop, Kathryn
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Mayo Clinic