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作者：Vaitiekenas, S.
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作者：Medeiros, Tania Catarina; Ovciarikova, Jana; Li, Xianhe; Krueger, Patrick; Bartsch, Tim; Reato, Silvia; Crow, John C.; Tellez Sutterlin, Michelle; Martins Garcia, Bruna; Rais, Irina; Allmeroth, Kira; Hartman, Matias D.; Denzel, Martin S.; Purrio, Martin; Mesaros, Andrea; Leung, Kit-Yi; Greene, Nicholas D. E.; Sheiner, Lilach; Giavalisco, Patrick; Pernas, Lena
作者单位：Max Planck Society; University of Glasgow; University of California System; University of California Los Angeles; University of California System; Howard Hughes Medical Institute; University of California Los Angeles; Max Planck Society; Max Planck Society; University of London; University College London; Max Planck Society
摘要：As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protect from infection is unclear. In this work, we found that the activating transcription factor 4 (ATF4) activates a mitochondrial defense based on the essential B vitamin folate. During infection of cultured mammalian cells with the intracellular pathogen Toxoplasma gondii, ATF4 increased mitochondr...
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作者：Reardon, Sara
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作者：Kim, Minju; Zhang, Mingyue; Zhu, You-Liang; Yan, Yan; Pu, Xin; Choi, Woosung; Chung, Sein; Cho, Kilwon; Kim, Jeongwon; Tsukruk, Vladimir; Yang, Zhenzhong; Kotov, Nicholas A.; Lu, Zhong-Yuan; Kim, Dong Ha; Lin, Zhiqun
作者单位：National University of Singapore; Ewha Womans University; Jilin University; Anhui University of Technology; University System of Georgia; Georgia Institute of Technology; Pohang University of Science & Technology (POSTECH); Tsinghua University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Ewha Womans University; Ewha Womans University; Ewha Womans University; Ewha Womans University
摘要：Supramolecular assemblies hold great promise for advanced chiral materials because of their structural diversity and dynamic features, but their low chiroptical activity limits practical applications. We report hierarchical supramolecular assemblies with giant chiroptical activity and mechanical attributes achieved through coassembly of achiral amphiphilic unimolecular micelles and chiral additives. Chiral fibrillar assemblies emerge from the nanostructured environment imposed by the micelles,...
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作者：Krammer, Sorin M. S.
作者单位：University of Southampton
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作者：Maldacena, j.
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作者：Wang, Jinxin; Yin, Yunpeng; Zhang, Quan; Zhang, Wei-Dong; Li, Jian
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Naval Medical University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Medicinal Plant Development - CAMS
摘要：Efficient asymmetric epoxidation reactions have been developed for both the head end and tail end double bonds of farnesol, greatly facilitating the synthesis of terpenoid natural products. However, the lack of methods for direct asymmetric epoxidation of the relatively inert internal alkene of farnesol has posed major challenges in the synthesis of many terpenoids. In this study, we describe the engineering of an epoxidase capable of selectively epoxidizing the internal alkene of farnesol wit...
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作者：Cutts, Elise
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作者：Holst, Bodil
作者单位：University of Bergen
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作者：Cohen, Jon
