6761期

最新文章

• Flux-induced topological superconductivity in full-shell nanowires (vol 367, 10.1126/science.aav3392, 2020) AI翻译
  作者：Vaitiekenas, S.
• Scientists' role in defending democracy AI翻译
  作者：Goldman, Gretchen; Chenoweth, Erica
  作者单位：Harvard University
• Modulation of methyl-coenzyme M reductase expression alters the isotopic composition of microbial methane AI翻译
  作者：Gropp, Jonathan; Bill, Markus; Lloyd, Max K.; Stein, Rebekah A.; Nayak, Dipti D.; Stolper, Daniel A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Berkeley
  摘要：The stable isotopic composition of microbial methane varies substantially, and the underlying causes are debated. In this work, we experimentally controlled the abundance of the central enzyme in methanogenesis, methyl-coenzyme M reductase (MCR), in Methanosarcina acetivorans and tested whether its cellular concentration alters methane isotopic compositions. We found that during growth on methanol and acetate, lowering the expression of mcr increases the degree of hydrogen isotope exchange bet...
• Enantioconvergent benzylic C(sp3)-N coupling with a copper-substituted nonheme enzyme AI翻译
  作者：Shen, Xuzhong; Chen, Xiahe; Xiao, Yihang; Brown, Jesse B.; Zhang, James G.; Ji, Xinyuan; Rui, Jinyan; Garcia-Borras, Marc; Rao, Yi; Yang, Yunfang; Huang, Xiongyi
  作者单位：Johns Hopkins University; Zhejiang University of Technology; Utah System of Higher Education; Utah State University; Universitat de Girona; Universitat de Girona
  摘要：Copper-catalyzed radical C(sp3)-N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In this study, we introduce a photobiocatalytic approach for radical benzylic C(sp3)-N coupling using a copper-substituted nonheme enzyme. Using rhodamine B as a photoredox catalyst, we identified a copper-substituted phenylalanine hydroxylase that facilitates enantioconvergent decarboxylative amination...
• The ins and outs of circulating DNA AI翻译
  作者：Tsui, W. H. Adrian; Lo, Y. M. Dennis
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong
• Leading a lab, and all it entails AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
• The proteome of the late Middle Pleistocene Harbin individual AI翻译
  作者：Fu, Qiaomei; Bai, Fan; Rao, Huiyun; Chen, Shaokun; Ji, Yannan; Liu, Aoran; Bennett, E. Andrew; Liu, Feng; Ji, Qiang
  作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hebei GEO University; China Geological Survey; Chinese Academy of Geological Sciences
  摘要：Denisovans are a hominin group primarily known through genomes or proteins, but their precise morphological features remain elusive because of the fragmentary nature of the discovered fossils. Here, we report 95 endogenous proteins retrieved from a nearly complete cranium from Harbin, China, dating to at least 146,000 years ago and previously assigned to a new species, Homo longi. This individual has three Denisovan-derived amino acid variants and clusters with Denisova 3, suggesting that the ...
• How I learned to ride AI翻译
  作者：Hamzehpoor, Ehsan
  作者单位：Universite de Montreal
• Twist on PET unlocks hidden signals AI翻译
  作者：Savitsky, Zack