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作者：Kim, Minju; Zhang, Mingyue; Zhu, You-Liang; Yan, Yan; Pu, Xin; Choi, Woosung; Chung, Sein; Cho, Kilwon; Kim, Jeongwon; Tsukruk, Vladimir; Yang, Zhenzhong; Kotov, Nicholas A.; Lu, Zhong-Yuan; Kim, Dong Ha; Lin, Zhiqun
作者单位：National University of Singapore; Ewha Womans University; Jilin University; Anhui University of Technology; University System of Georgia; Georgia Institute of Technology; Pohang University of Science & Technology (POSTECH); Tsinghua University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Ewha Womans University; Ewha Womans University; Ewha Womans University; Ewha Womans University
摘要：Supramolecular assemblies hold great promise for advanced chiral materials because of their structural diversity and dynamic features, but their low chiroptical activity limits practical applications. We report hierarchical supramolecular assemblies with giant chiroptical activity and mechanical attributes achieved through coassembly of achiral amphiphilic unimolecular micelles and chiral additives. Chiral fibrillar assemblies emerge from the nanostructured environment imposed by the micelles,...
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作者：Krammer, Sorin M. S.
作者单位：University of Southampton
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作者：Mabalay, Adrian A.
作者单位：De La Salle University
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作者：Tanaka, Ryoya; Hara, Yusuke; Sato, Kosei; Kohatsu, Soh; Murakami, Hinata; Higuchi, Tomohiro; Awasaki, Takeshi; Kondo, Shu; Toyoda, Atsushi; Kamikouchi, Azusa; Yamamoto, Daisuke
作者单位：Nagoya University; National Institute of Information & Communications Technology (NICT) - Japan; Tohoku University; Kyorin University; Tokyo University of Science; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan
摘要：In accepting a courting male, Drosophila subobscura females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in D. melanogaster. By clonal activation of neurons expressing the male-determinant FruM, we identified insulin-like peptide-producing cells (IPCs) and their putative postsynaptic targets, proboscis-innervating motoneurons, as those critical for gift giving. We demonstrate that loss of FruM from D. subobscur...
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作者：Thorp, H. Holden
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作者：Gao, Yueze; Gupta, Prakhar; Roncevic, Igor; Mycroft, Coral; Gates, Paul J.; Parker, Anthony W.; Anderson, Harry L.
作者单位：University of Oxford; University of Manchester; University of Bristol; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory
摘要：Cyclo[N]carbons, molecular rings consisting solely of N carbon atoms, have previously been studied in the gas phase and on surfaces at cryogenic temperatures, but they are generally considered too reactive to be studied under ambient laboratory conditions. In this study, we report the synthesis of a cyclo[48]carbon catenane, in which the C48 ring is protected by being threaded through three other macrocycles. This cyclo[48]carbon [4]catenane is stable enough for spectroscopic characterization ...
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作者：Glaberman, Scott; Wei, Cynthia
作者单位：University of Birmingham; Georgetown University
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作者：Maldacena, j.
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作者：Wang, Jinxin; Yin, Yunpeng; Zhang, Quan; Zhang, Wei-Dong; Li, Jian
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Naval Medical University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Medicinal Plant Development - CAMS; Peking Union Medical College
摘要：Efficient asymmetric epoxidation reactions have been developed for both the head end and tail end double bonds of farnesol, greatly facilitating the synthesis of terpenoid natural products. However, the lack of methods for direct asymmetric epoxidation of the relatively inert internal alkene of farnesol has posed major challenges in the synthesis of many terpenoids. In this study, we describe the engineering of an epoxidase capable of selectively epoxidizing the internal alkene of farnesol wit...
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作者：Medeiros, Tania Catarina; Ovciarikova, Jana; Li, Xianhe; Krueger, Patrick; Bartsch, Tim; Reato, Silvia; Crow, John C.; Tellez Sutterlin, Michelle; Martins Garcia, Bruna; Rais, Irina; Allmeroth, Kira; Hartman, Matias D.; Denzel, Martin S.; Purrio, Martin; Mesaros, Andrea; Leung, Kit-Yi; Greene, Nicholas D. E.; Sheiner, Lilach; Giavalisco, Patrick; Pernas, Lena
作者单位：Max Planck Society; University of Glasgow; University of California System; University of California Los Angeles; Howard Hughes Medical Institute; University of California System; University of California Los Angeles; Max Planck Society; Max Planck Society; University of London; University College London; Max Planck Society
摘要：As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protect from infection is unclear. In this work, we found that the activating transcription factor 4 (ATF4) activates a mitochondrial defense based on the essential B vitamin folate. During infection of cultured mammalian cells with the intracellular pathogen Toxoplasma gondii, ATF4 increased mitochondr...
