6761期

最新文章

• Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA AI翻译
  作者：Murphy, Lauren; Inchauspe, Jeanne; Valenzano, Giampiero; Holland, Pamela; Sousos, Nikolaos; Belnoue-Davis, Hayley L.; Li, Rong; Jooss, Natalie J.; Benlabiod, Camelia; Murphy, Eleanor; Etzioni, Zohar; Shepherd, Emelie; Denly, Lucy; Biswas, Sujata; Chen, Lin; O'Sullivan, Jennifer; Rimmer, Michael P.; Khan, Abdullah O.; Karali, Christina Simoglou; Nasreddin, Nadia; Hitchcock, Ian S.; Koupenova, Milka; Kriaucionis, Skirmantas; Hughes, Jim R.; O'Neill, Eric; Vatish, Manu; Rees, Paul; Leedham, Simon; Desborough, Michael; Mead, Adam J.; Schuster-Bockler, Benjamin; Gregory, Christopher D.; Psaila, Bethan
  作者单位：University of Oxford; University of Oxford; University of Oxford; Ludwig Institute for Cancer Research; University of Oxford; University of Edinburgh; Oxford University Hospitals NHS Foundation Trust; University of Oxford; Wellcome Centre for Human Genetics; University of York - UK; University of York - UK; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Oxford; Swansea University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in cell-free DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained a repertoire of DNA fragments mapping across the nuclear genome. We detected fetal D...
• Addressing Southeast Asia's plastic pollution AI翻译
  作者：Xayachak, Tu; Haque, Nawshad; Pramanik, Biplob Kumar
  作者单位：Royal Melbourne Institute of Technology (RMIT); Commonwealth Scientific & Industrial Research Organisation (CSIRO)
• Editor's Note AI翻译
  作者：Thorp, H. Holden
• Early germline sequestration in a basidiomycete fungus AI翻译
  作者：Thoren, Markus Hiltunen; Olsson, Boel; Vonk, Peter Jan; Siljestam, Mattias; Reimegard, Johan; Ryberg, Martin; Johannesson, Hanna
  作者单位：Stockholm University; Royal Swedish Academy of Sciences; Uppsala University; Uppsala University
  摘要：In sexual organisms, inheritance of new mutations is highly dependent on the timing of germline definition. Here, we used the fairy ring-forming fungus Marasmius oreades to challenge the general assumption of a late germline separation in the Fungi. We collected mushrooms from different parts of rings over a 7-year period and identified new mutations in different tissues by whole-genome sequencing. We found evidence that fertile and sterile tissues had accumulated different mutations, suggesti...
• Correction in Science rekindles debate over Microsoft's quantum computing research AI翻译
  作者：Mann, Adam
• Trump moves to politicize decisions on science grants AI翻译
  作者：Mervis, Jeffrey
• Setting the table for immune tolerance AI翻译
  作者：Silverman, Michael; Knoop, Kathryn
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Mayo Clinic
• West Philippine Sea dispute threatens sea life AI翻译
  作者：Mabalay, Adrian A.
  作者单位：De La Salle University
• Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene AI翻译
  作者：Tanaka, Ryoya; Hara, Yusuke; Sato, Kosei; Kohatsu, Soh; Murakami, Hinata; Higuchi, Tomohiro; Awasaki, Takeshi; Kondo, Shu; Toyoda, Atsushi; Kamikouchi, Azusa; Yamamoto, Daisuke
  作者单位：Nagoya University; National Institute of Information & Communications Technology (NICT) - Japan; Tohoku University; Kyorin University; Tokyo University of Science; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan
  摘要：In accepting a courting male, Drosophila subobscura females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in D. melanogaster. By clonal activation of neurons expressing the male-determinant FruM, we identified insulin-like peptide-producing cells (IPCs) and their putative postsynaptic targets, proboscis-innervating motoneurons, as those critical for gift giving. We demonstrate that loss of FruM from D. subobscur...
• Scalable emulation of protein equilibrium ensembles with generative deep learning AI翻译
  作者：Lewis, Sarah; Hempel, Tim; Jimenez-Luna, Jose; Gastegger, Michael; Xie, Yu; Foong, Andrew Y. K.; Satorras, Victor Garcia; Abdin, Osama; Veeling, Bastiaan S.; Zaporozhets, Iryna; Chen, Yaoyi; Yang, Soojung; Foster, Adam E.; Schneuing, Arne; Nigam, Jigyasa; Barbero, Federico; Stimper, Vincent; Campbell, Andrew; Yim, Jason; Lienen, Marten; Shi, Yu; Zheng, Shuxin; Schulz, Hannes; Munir, Usman; Sordillo, Roberto; Tomioka, Ryota; Clementi, Cecilia; Noe, Frank
  作者单位：Microsoft; Free University of Berlin; Rice University
  摘要：Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that emulates protein equilibrium ensembles by generating thousands of statistically independent structures per hour on a single graphics processing unit (GPU). BioEmu integrates more than 200 milliseconds of molecular dynamics (MD) simulations, static structures, and experimental protein stabilities ...