8039期

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• Mosquito taste responses to human and floral cues guide biting and feeding AI翻译
  作者：Baik, Lisa S.; Talross, Gaelle J. S.; Gray, Sydney; Pattisam, Himani S.; Peterson, Taylor N.; Nidetz, James E.; Hol, Felix J. H.; Carlson, John R.
  作者单位：Yale University; Radboud University Nijmegen
  摘要：The taste system controls many insect behaviours, yet little is known about how tastants are encoded in mosquitoes or how they regulate critical behaviours. Here we examine how taste stimuli are encoded by Aedes albopictus mosquitoes-a highly invasive disease vector-and how these cues influence biting, feeding and egg laying. We find that neurons of the labellum, the major taste organ of the head, differentially encode a wide variety of human and other cues. We identify three functional classe...
• A prenatal skin atlas reveals immune regulation of human skin morphogenesis AI翻译
  作者：Gopee, Nusayhah Hudaa; Winheim, Elena; Olabi, Bayanne; Admane, Chloe; Foster, April Rose; Huang, Ni; Botting, Rachel A.; Torabi, Fereshteh; Sumanaweera, Dinithi; Le, Anh Phuong; Kim, Jin; Verger, Luca; Stephenson, Emily; Adao, Diana; Ganier, Clarisse; Gim, Kelly Y.; Serdy, Sara A.; Deakin, Cici; Goh, Issac; Steele, Lloyd; Annusver, Karl; Miah, Mohi-Uddin; Tun, Win Min; Moghimi, Pejvak; Kwakwa, Kwasi Amoako; Li, Tong; Lozada, Daniela Basurto; Rumney, Ben; Tudor, Catherine L.; Roberts, Kenny; Chipampe, Nana-Jane; Sidhpura, Keval; Englebert, Justin; Jardine, Laura; Reynolds, Gary; Rose, Antony; Rowe, Vicky; Pritchard, Sophie; Mulas, Ilaria; Fletcher, James; Popescu, Dorin-Mirel; Poyner, Elizabeth; Dubois, Anna; Guy, Alyson; Filby, Andrew; Lisgo, Steven; Barker, Roger A.; Glass, Ian A.; Park, Jong-Eun; Vento-Tormo, Roser; Nikolova, Marina Tsvetomilova; He, Peng; Lawrence, John E. G.; Moore, Josh; Ballereau, Stephane; Hale, Christine B.; Shanmugiah, Vijaya; Horsfall, David; Rajan, Neil; McGrath, John A.; O'Toole, Edel A.; Treutlein, Barbara; Bayraktar, Omer; Kasper, Maria; Progatzky, Franze; Mazin, Pavel; Lee, Jiyoon; Gambardella, Laure; Koehler, Karl R.; Teichmann, Sarah A.; Haniffa, Muzlifah
  作者单位：Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Wellcome Trust Sanger Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of Oxford; Kennedy Institute for Rheumatology; Karolinska Institutet; University of Cambridge; University of Cambridge; University of Washington; University of Washington Seattle; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California San Francisco; University of London; King's College London; University of London; Queen Mary University London
  摘要：Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics reference atlas of prenatal human skin (7-17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches of the skin. This atlas revealed that crosstalk between non-immune and immune cells underpins the f...
• A bacterial immunity protein directly senses two disparate phage proteins AI翻译
  作者：Zhang, Tong; Cepauskas, Albinas; Nadieina, Anastasiia; Thureau, Aurelien; 't Wallant, Kyo Coppieters; Martens, Chloe; Lim, Daniel C.; Garcia-Pino, Abel; Laub, Michael T.
  作者单位：Massachusetts Institute of Technology (MIT); Universite Libre de Bruxelles; Universite Libre de Bruxelles; SOLEIL Synchrotron; WELBIO; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT)
  摘要：Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense certain components of their viral predators, known as bacteriophages1-6. Although different immunity proteins can recognize different phage-encoded triggers, individual bacterial immunity proteins have been found to sense only a single trigger during infecti...
• A giant planet transiting a 3-Myr protostar with a misaligned disk AI翻译
  作者：Barber, Madyson G.; Mann, Andrew W.; Vanderburg, Andrew; Krolikowski, Daniel; Kraus, Adam; Ansdell, Megan; Pearce, Logan; Mace, Gregory N.; Andrews, Sean M.; Boyle, Andrew W.; Collins, Karen A.; De Furio, Matthew; Dragomir, Diana; Espaillat, Catherine; Feinstein, Adina D.; Fields, Matthew; Jaffe, Daniel; Lopez Murillo, Ana Isabel; Murgas, Felipe; Newton, Elisabeth R.; Palle, Enric; Sawczynec, Erica; Schwarz, Richard P.; Thao, Pa Chia; Tofflemire, Benjamin M.; Watkins, Cristilyn N.; Jenkins, Jon M.; Latham, David W.; Ricker, George; Seager, Sara; Vanderspek, Roland; Winn, Joshua N.; Charbonneau, David; Essack, Zahra; Rodriguez, David R.; Shporer, Avi; Twicken, Joseph D.; Villasenor, Jesus Noel
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Arizona; University of Texas System; University of Texas Austin; National Aeronautics & Space Administration (NASA); Mary W. Jackson NASA Headquarters; Smithsonian Institution; University of New Mexico; Boston University; University of Colorado System; University of Colorado Boulder; Instituto de Astrofisica de Canarias; Universidad de la Laguna; Dartmouth College; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Princeton University; Space Telescope Science Institute; SETI Institute
  摘要：Astronomers have found more than a dozen planets transiting stars that are 10-40 million years old1, but younger transiting planets have remained elusive. The lack of such discoveries may be because planets have not fully formed at this age or because our view is blocked by the protoplanetary disk. However, we now know that many outer disks are warped or broken2; provided the inner disk is depleted, transiting planets may thus be visible. Here we report observations of the transiting planet IR...
• Reducing pregnancy risk could be as easy as chewing gum AI翻译
  作者：[Anonymous]
• Single-cell integration reveals metaplasia in inflammatory gut diseases AI翻译
  作者：Oliver, Amanda J.; Huang, Ni; Bartolome-Casado, Raquel; Li, Ruoyan; Koplev, Simon; Nilsen, Hogne R.; Moy, Madelyn; Cakir, Batuhan; Polanski, Krzysztof; Gudino, Victoria; Melon-Ardanaz, Elisa; Sumanaweera, Dinithi; Dimitrov, Daniel; Milchsack, Lisa Marie; FitzPatrick, Michael E. B.; Provine, Nicholas M.; Boccacino, Jacqueline M.; Dann, Emma; Predeus, Alexander, V; To, Ken; Prete, Martin; Chapman, Jonathan A.; Masi, Andrea C.; Stephenson, Emily; Engelbert, Justin; Lobentanzer, Sebastian; Perera, Shani; Richardson, Laura; Kapuge, Rakeshlal; Wilbrey-Clark, Anna; Semprich, Claudia, I; Ellams, Sophie; Tudor, Catherine; Joseph, Philomeena; Garrido-Trigo, Alba; Corraliza, Ana M.; Oliver, Thomas R. W.; Hook, C. Elizabeth; James, Kylie R.; Mahbubani, Krishnaa T.; Saeb-Parsy, Kourosh; Zilbauer, Matthias; Saez-Rodriguez, Julio; Hoivik, Marte Lie; Baekkevold, Espen S.; Stewart, Christopher J.; Berrington, Janet E.; Meyer, Kerstin B.; Klenerman, Paul; Salas, Azucena; Haniffa, Muzlifah; Jahnsen, Frode L.; Elmentaite, Rasa; Teichmann, Sarah A.
  作者单位：Wellcome Trust Sanger Institute; University of Oslo; University of Oslo; National Hospital Norway; University of Texas System; UTMD Anderson Cancer Center; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Ruprecht Karls University Heidelberg; University of Oxford; Newcastle University - UK; University of Cambridge; University of Cambridge; Garvan Institute of Medical Research; University of New South Wales Sydney; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Oslo; University of Oslo; University of Oxford; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle Upon Tyne Hospitals NHS Foundation Trust; University of Cambridge; University of Cambridge; Canadian Institute for Advanced Research (CIFAR)
  摘要：The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics and a surge in gastrointestinal diseases(1,2) has fuelled efforts to catalogue cells constituting gastrointestinal tissues in health and disease(3). Here we present systematic integration of 25 single-cell RNA sequencing datasets spanning the entire healthy gastrointestinal tract in development and in adulthood. We uniformly processed 385 samples from 189 healthy ...
• Revised historical record sharpens perspective on global warming AI翻译
  作者：Osborn, Timothy J.; Kennedy, John J.
  作者单位：University of East Anglia
• Mapping groundwater-dependent ecosystems shows the need for more protection globally AI翻译
  作者：Rohde, Melissa M.
  摘要：Ecosystems reliant on groundwater are vulnerable to water depletion and climate change, but often their locations are unknown. A map of groundwater-dependent ecosystems across global drylands provides essential information to advance the protection of these biologically diverse ecosystems and the rural societies that depend on them.
• Trion sensing of a zero-field composite Fermi liquid AI翻译
  作者：Anderson, Eric; Cai, Jiaqi; Reddy, Aidan P.; Park, Heonjoon; Holtzmann, William; Davis, Kai; Taniguchi, Takashi; Watanabe, Kenji; Smolenski, Tomasz; Imamoglu, Atac; Cao, Ting; Xiao, Di; Fu, Liang; Yao, Wang; Xu, Xiaodong
  作者单位：University of Washington; University of Washington Seattle; Massachusetts Institute of Technology (MIT); University of Washington; University of Washington Seattle; National Institute for Materials Science; National Institute for Materials Science; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Hong Kong
  摘要：The half-filled lowest Landau level is a fascinating platform for researching interacting topological phases. A celebrated example is the composite Fermi liquid, a non-Fermi liquid formed by composite fermions in strong magnetic fields1-10. Its zero-field counterpart is predicted in a twisted MoTe2 bilayer (tMoTe2)11,12-a recently discovered fractional Chern insulator exhibiting the fractional quantum anomalous Hall effect13-16. Although transport measurements at nu = -1/2 show signatures cons...
• Tomato engineering hits the sweet spot AI翻译
  作者：Lanctot, Amy; Shih, Patrick M.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Joint BioEnergy Institute - JBEI
  摘要：A genetic regulator of tomato sweetness has been identified through comparison of wild and domesticated varieties of the plant. Genetically engineering tomatoes to alter this gene increases sugar content without affecting fruit size.