8039期

最新文章

• What a forest's glow can reveal about the impact of environmental change AI翻译
  作者：Leeming, Jack
  摘要：Albert Porcar Castell runs a small outdoor laboratory to draw connections between red-light fluorescence and gas exchange.
• CRISPR builds a big tomato that's actually sweet AI翻译
  作者：Kozlov, Max
  摘要：Deleting just two genes that control sugar production makes a more succulent fruit.
• 'Heroic interference' should not be the endgame of coral-reef restoration AI翻译
  作者：Matz, Mikhail
  作者单位：University of Texas System; University of Texas Austin
• A 'Wikipedia for cells': researchers get an updated look at the Human Cell Atlas, and it's remarkable AI翻译
  作者：[Anonymous]
  摘要：Coming less than a decade after its launch, the studies emerging from the global project are a major achievement. Funders should sign up for the long haul.
• CAN STUDENTS AND GRANDPARENTS SOLVE THE GLOBAL CRISIS IN MENTAL HEALTH? AI翻译
  作者：Bajaj, Simar
• How a silly science prize changed my career AI翻译
  作者：Clarke, Catriona
  摘要：A levitating frog, a necrophiliac duck, taxi drivers' brains - the Ig Nobel prizes have shined a spotlight on offbeat work. Here's an inside look at how winners feel about this sometimes unwanted 'honour'.
• Early-twentieth-century cold bias in ocean surface temperature observations AI翻译
  作者：Sippel, Sebastian; Kent, Elizabeth C.; Meinshausen, Nicolai; Chan, Duo; Kadow, Christopher; Neukom, Raphael; Fischer, Erich M.; Humphrey, Vincent; Rohde, Robert; de Vries, Iris; Knutti, Reto
  作者单位：Leipzig University; Swiss Federal Institutes of Technology Domain; ETH Zurich; NERC National Oceanography Centre; Swiss Federal Institutes of Technology Domain; ETH Zurich; NERC National Oceanography Centre; University of Southampton; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Federal Office of Meteorology & Climatology (MeteoSwiss)
  摘要：The observed temperature record, which combines sea surface temperatures with near-surface air temperatures over land, is crucial for understanding climate variability and change1-4. However, early records of global mean surface temperature are uncertain owing to changes in measurement technology and practice, partial documentation5-8, and incomplete spatial coverage9. Here we show that existing estimates of ocean temperatures in the early twentieth century (1900-1930) are too cold, based on i...
• Structure of the human TIP60-C histone exchange and acetyltransferase complex AI翻译
  作者：Li, Changqing; Smirnova, Ekaterina; Schnitzler, Charlotte; Crucifix, Corinne; Concordet, Jean Paul; Brion, Alice; Poterszman, Arnaud; Schultz, Patrick; Papai, Gabor; Ben-Shem, Adam
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
  摘要：Chromatin structure is a key regulator of DNA transcription, replication and repair1. In humans, the TIP60-EP400 complex (TIP60-C) is a 20-subunit assembly that affects chromatin structure through two enzymatic activities: ATP-dependent exchange of histone H2A-H2B for H2A.Z-H2B, and histone acetylation. In yeast, however, these activities are performed by two independent complexes-SWR1 and NuA4, respectively2,3. How the activities of the two complexes are merged into one supercomplex in humans...
• Cellular ATP demand creates metabolically distinct subpopulations of mitochondria AI翻译
  作者：Ryu, Keun Woo; Fung, Tak Shun; Baker, Daphne C.; Saoi, Michelle; Park, Jinsung; Febres-Aldana, Christopher A.; Aly, Rania G.; Cui, Ruobing; Sharma, Anurag; Fu, Yi; Jones, Olivia L.; Cai, Xin; Pasolli, H. Amalia; Cross, Justin R.; Rudin, Charles M.; Thompson, Craig B.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Mitochondria serve a crucial role in cell growth and proliferation by supporting both ATP synthesis and the production of macromolecular precursors. Whereas oxidative phosphorylation (OXPHOS) depends mainly on the oxidation of intermediates from the tricarboxylic acid cycle, the mitochondrial production of proline and ornithine relies on reductive synthesis1. How these competing metabolic pathways take place in the same organelle is not clear. Here we show that when cellular dependence on OXPH...
• Superconductivity in twisted bilayer WSe2 AI翻译
  作者：Xia, Yiyu; Han, Zhongdong; Watanabe, Kenji; Taniguchi, Takashi; Shan, Jie; Mak, Kin Fai
  作者单位：Cornell University; Cornell University; National Institute for Materials Science
  摘要：Moir & eacute; materials have enabled the realization of flat electron bands and quantum phases that are driven by the strong correlations associated with flat bands1-4. Superconductivity has been observed, but only in graphene moir & eacute; materials5-9. The absence of robust superconductivity in moir & eacute; materials beyond graphene, such as semiconductor moir & eacute; materials4, has remained a mystery and challenged our current understanding of superconductivity in flat bands. Here we...