-
作者：Nordling, Linda
摘要：From demonstrating technical prowess to setting out future ambitions, learn how to beat rival candidates and land your dream job.
-
作者：Zhang, Shen-Ying; Casanova, Jean-Laurent
作者单位：Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
摘要：Herpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in humans. It is life-threatening and has a first peak of incidence in childhood, during primary infection. Children with HSE are not particularly prone to other infections, including HSV-1 infections of tissues other than the brain. About 8-10% of childhood cases are due to monogenic inborn errors of 19 genes, two-thirds of which are recessive, and most of which display incomplete clinical penetra...
-
作者：[Anonymous]
-
作者：Cardenas, Maria A.; Prokhnevska, Nataliya; Sobierajska, Ewelina; Gregorova, Petra; Medina, Christopher B.; Valanparambil, Rajesh M.; Greenwald, Rachel; Delbalzo, Luke; Bilen, Mehmet Asim; Joshi, Shreyas S.; Narayan, Vikram M.; Master, Viraj A.; Sanda, Martin G.; Kissick, Haydn T.
-
作者：Victor, David G.
作者单位：University of California System; University of California San Diego
摘要：The US president-elect says he will pull the country out of international treaties and partnerships. That need not lead to disorder.
-
作者：Yanai, Itai; Haas, Simon; Lippert, Christoph; Kretzmer, Helene
作者单位：NYU Langone Medical Center; NYU Langone Medical Center; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; University of London; Queen Mary University London; University of Potsdam; Icahn School of Medicine at Mount Sinai; Max Planck Society
-
作者：Pernas, Lena
作者单位：University of California System; University of California Los Angeles; Howard Hughes Medical Institute
摘要：How do mitochondria, the cell's energy-producing organelles, perform competing metabolic processes? Segregation into distinct populations - one that makes energy-storing ATP molecules and one that does not - could explain it.
-
作者：Li, Dong; Xiao, Yu; Fedorova, Iana; Xiong, Weijia; Wang, Yu; Liu, Xi; Huiting, Erin; Ren, Jie; Gao, Zirui; Zhao, Xingyu; Cao, Xueli; Zhang, Yi; Bondy-Denomy, Joseph; Feng, Yue
作者单位：Beijing University of Chemical Technology; Chinese Academy of Sciences; Tsinghua University; University of California System; University of California San Francisco; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; University of California System; University of California San Francisco
摘要：Prokaryotic anti-phage immune systems use TIR and cGAS-like enzymes to produce 1 ''-3 '-glycocyclic ADP- ribose (1 ''-3 '-gcADPR) and cyclic dinucleotide (CDN) and cyclic trinucleotide (CTN) signalling molecules, respectively, which limit phage replication(1-3). However, how phages neutralize these distinct and common systems is largely unclear. Here we show that the Thoeris anti-defence proteins Tad1(4) and Tad2(5) both achieve anti-cyclic-oligonucleotide-based anti-phage signalling system (a...
-
作者：Dance, Amber
-
作者：[Anonymous]
