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作者：Glausiusz, Josie
摘要：Scientists, tech entrepreneurs and educators on both sides of the border describe the devastation of lost homes, destroyed laboratories and slain colleagues. Scientists, tech entrepreneurs and educators on both sides of the border describe the devastation of lost homes, destroyed laboratories and slain colleagues.
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作者：Kliegman, Melinda; Zaghlula, Manar; Abrahamson, Susan; Esensten, Jonathan H.; Wilson, Ross C.; Urnov, Fyodor D.; Doudna, Jennifer A.
作者单位：University of California System; University of California Berkeley; Tel Aviv University; Chaim Sheba Medical Center; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Twenty genetic therapies have been approved by the US Food and Drug Administration to date, a number that now includes the first CRISPR genome-editing therapy for sickle cell disease-CASGEVY (exagamglogene autotemcel, Vertex Pharmaceuticals). This extraordinary milestone is widely celebrated owing to the promise for future genome-editing treatments of previously intractable genetic disorders and cancers. At the same time, such genetic therapies are the most expensive drugs on the market, with ...
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作者：Cao, Alec; Eckner, William J.; Yelin, Theodor Lukin; Young, Aaron W.; Jandura, Sven; Yan, Lingfeng; Kim, Kyungtae; Pupillo, Guido; Ye, Jun; Oppong, Nelson Darkwah; Kaufman, Adam M.
作者单位：University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
摘要：Many-particle entanglement is a key resource for achieving the fundamental precision limits of a quantum sensor1. Optical atomic clocks2, the current state of the art in frequency precision, are a rapidly emerging area of focus for entanglement-enhanced metrology3-6. Augmenting tweezer-based clocks featuring microscopic control and detection7-10 with the high-fidelity entangling gates developed for atom-array information processing11,12 offers a promising route towards making use of highly ent...
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作者：Deep, Amar; Liang, Qishan; Enustun, Eray; Pogliano, Joe; Corbett, Kevin D.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Bacteria and their viruses (bacteriophages or phages) are engaged in an intense evolutionary arms race(1-5). While the mechanisms of many bacterial antiphage defence systems are known(1), how these systems avoid toxicity outside infection yet activate quickly after infection is less well understood. Here we show that the bacterial phage anti-restriction-induced system (PARIS) operates as a toxin-antitoxin system, in which the antitoxin AriA sequesters and inactivates the toxin AriB until trigg...
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作者：Ceppi, Ilaria; Dello Stritto, Maria Rosaria; Muetze, Martin; Braunshier, Stefan; Mengoli, Valentina; Reginato, Giordano; Ho My Phuc Vo; Jimeno, Sonia; Acharya, Ananya; Roy, Megha; Sanchez, Aurore; Halder, Swagata; Howard, Sean Michael; Guerois, Raphael; Huertas, Pablo; Noordermeer, Sylvie M.; Seidel, Ralf; Cejka, Petr
作者单位：Universita della Svizzera Italiana; Leipzig University; Leiden University; Leiden University Medical Center (LUMC); University of Sevilla; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CNRS - National Institute for Biology (INSB); Boise State University
摘要：DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA end resection, a process involving the controlled degradation of the 5-terminated strands at DSB sites(1,2). The breast cancer suppressor BRCA1-BARD1 not only promotes resection and homologous recombination, but it also protects DNA upon replication stress(1,3-9). BRCA1-BARD1 counteracts the anti-resection and pro-non-homologous end-joining factor 53BP1, but whether it functions in resection directly has been ...
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作者：Yue, Wendy W. S.; Touhara, Kouki K.; Toma, Kenichi; Duan, Xin; Julius, David
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：After injury, mammalian spinal cords develop scars to confine the lesion and prevent further damage. However, excessive scarring can hinder neural regeneration and functional recovery1,2. These competing actions underscore the importance of developing therapeutic strategies to dynamically modulate scar progression. Previous research on scarring has primarily focused on astrocytes, but recent evidence has suggested that ependymal cells also participate. Ependymal cells normally form the epithel...
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作者：Aryal, Achyut
作者单位：Tribhuvan University; Institute of Forestry (IOF) - Nepal; University of Technology Sydney
摘要：Governments should encourage researchers to stay and boost the economies of their home countries rather than working overseas.
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作者：Francl, Michelle
作者单位：Bryn Mawr College; Vatican Observatory
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作者：Ozer, Emre; Kufel, Jedrzej; Prakash, Shvetank; Raisiardali, Alireza; Kindgren, Olof; Wong, Ronald; Ng, Nelson; Jausseran, Damien; Alkhalil, Feras; Kong, David; Hills, Gage; Price, Richard; Reddi, Vijay Janapa
作者单位：Harvard University
摘要：Semiconductors have already had a very profound effect on society, accelerating scientific research and driving greater connectivity. Future semiconductor hardware will open up new possibilities in quantum computing, artificial intelligence and edge computing, for applications such as cybersecurity and personalized healthcare. By nature of its ethos, open hardware provides opportunities for even greater collaboration and innovations across education, academic research and industry. Here we pre...
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作者：Callaway, Ewen
