2024

最新文章

• Molecular programs guiding arealization of descending cortical pathways AI翻译
  作者：Abe, Philipp; Lavalley, Adrien; Morassut, Ilaria; Santinha, Antonio J.; Roig-Puiggros, Sergi; Javed, Awais; Klingler, Esther; Baumann, Natalia; Prados, Julien; Platt, Randall J.; Jabaudon, Denis
  作者单位：University of Geneva; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Geneva; Swiss Federal Institutes of Technology Domain; ETH Zurich; Flanders Institute for Biotechnology (VIB); University of Geneva; University of Basel; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite
  摘要：Layer 5 extratelencephalic (ET) neurons are present across neocortical areas and send axons to multiple subcortical targets1-6. Two cardinal subtypes exist7,8: (1) Slco2a1-expressing neurons (ETdist), which predominate in the motor cortex and project distally to the pons, medulla and spinal cord; and (2) Nprs1- or Hpgd-expressing neurons (ETprox), which predominate in the visual cortex and project more proximally to the pons and thalamus. An understanding of how area-specific ETdist and ETprox...
• Engineered T cell therapy for central nervous system injury AI翻译
  作者：Gao, Wenqing; Kim, Min Woo; Dykstra, Taitea; Du, Siling; Boskovic, Pavle; Lichti, Cheryl F.; Ruiz-Cardozo, Miguel A.; Gu, Xingxing; Weizman Shapira, Tal; Rustenhoven, Justin; Molina, Camilo; Smirnov, Igor; Merbl, Yifat; Ray, Wilson Z.; Kipnis, Jonathan
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Saint Louis University; Washington University (WUSTL); Weizmann Institute of Science
  摘要：Traumatic injuries to the central nervous system (CNS) afflict millions of individuals worldwide1, yet an effective treatment remains elusive. Following such injuries, the site is populated by a multitude of peripheral immune cells, including T cells, but a comprehensive understanding of the roles and antigen specificity of these endogenous T cells at the injury site has been lacking. This gap has impeded the development of immune-mediated cellular therapies for CNS injuries. Here, using singl...
• DEVELOPERS OF ALPHAFOLD WIN CHEMISTRY NOBEL AI翻译
  作者：Callaway, Ewen
• Conflict in New Caledonia endangers one of the world's biodiversity hotspots AI翻译
  作者：Oedin, Malik; Dombal, Yvy
• Revolutionary drug for schizophrenia wins US approval AI翻译
  作者：Dolgin, Elie
• GPS tracking reveals how hares shape lynx populations AI翻译
  作者：Klopper, Abigail
• The genetic architecture of protein stability AI翻译
  作者：Faure, Andre J.; Marti-Aranda, Aina; Hidalgo-Carcedo, Cristina; Beltran, Antoni; Schmiedel, Joern M.; Lehner, Ben
  作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Wellcome Trust Sanger Institute; Pompeu Fabra University
  摘要：There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are atoms in the universe. Only a very small fraction of such a vast sequence space can ever be experimentally or computationally surveyed. Deep neural networks are increasingly being used to navigate high-dimensional sequence spaces1. However, these models are extremely complicated. Here, by experimentally sampling from sequence spaces larger than 1010, we show that the genetic architecture of at least some pro...
• Stem cells reverse woman's diabetes - a world first AI翻译
  作者：Mallapaty, Smriti
• Nobel prizes are globally unrepresentative - the nomination process must be opened up AI翻译
  作者：[Anonymous]
  摘要：The geography of science is changing. As a result, a big push is needed to broaden the pool of scientists eligible to nominate their peers for Nobel prizes.
• Which is the fairest electoral system? Mega-election year sparks debate AI翻译
  作者：Skibba, Ramin
  摘要：Proportional representation or winner takes all? Here's how researchers compare the merits of contrasting voting methods.