2024

最新文章

• A jaw-dropping discovery about early mammals AI翻译
  作者：Luo, Zhe-Xi
• 'AFRAID TO TALK': RESEARCHERS FEAR END OF VENEZUELAN SCIENCE AI翻译
  作者：Taylor, Luke
• Overshooting global-warming limits is a risky idea AI翻译
  作者：Mengis, Nadine
  作者单位：Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel
• Future increase in extreme El Nino supported by past glacial changes AI翻译
  作者：Thirumalai, Kaustubh; DiNezio, Pedro N.; Partin, Judson W.; Liu, Dunyu; Costa, Kassandra; Jacobel, Allison
  作者单位：University of Arizona; University of Colorado System; University of Colorado Boulder; University of Texas System; University of Texas Austin; Woods Hole Oceanographic Institution; Middlebury College
  摘要：El Nino events, the warm phase of the El Nino-Southern Oscillation (ENSO) phenomenon, amplify climate variability throughout the world(1). Uncertain climate model predictions limit our ability to assess whether these climatic events could become more extreme under anthropogenic greenhouse warming(2). Palaeoclimate records provide estimates of past changes, but it is unclear if they can constrain mechanisms underlying future predictions(3-5). Here we uncover a mechanism using numerical simulati...
• THE HUGE TOLL OF PHDS ON MENTAL HEALTH: DATA REVEAL STARK EFFECTS AI翻译
  作者：Schwaller, Fred
• A multimodal generative AI copilot for human pathology AI翻译
  作者：Lu, Ming Y.; Chen, Bowen; Williamson, Drew F. K.; Chen, Richard J.; Zhao, Melissa; Chow, Aaron K.; Ikemura, Kenji; Kim, Ahrong; Pouli, Dimitra; Patel, Ankush; Soliman, Amr; Chen, Chengkuan; Ding, Tong; Wang, Judy J.; Gerber, Georg; Liang, Ivy; Le, Long Phi; Parwani, Anil V.; Weishaupt, Luca L.; Mahmood, Faisal
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); University System of Ohio; Ohio State University; Pusan National University; Mayo Clinic; Harvard University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University
  摘要：Computational pathology1,2 has witnessed considerable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders3,4. However, despite the explosive growth of generative artificial intelligence (AI), there have been few studies on building general-purpose multimodal AI assistants and copilots5 tailored to pathology. Here we present PathChat, a vision-language generalist AI assistant for human pathology. We built PathChat by adapting a f...
• Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination AI翻译
  作者：Salunkhe, Sameer; Daley, James M.; Kaur, Hardeep; Tomimatsu, Nozomi; Xue, Chaoyou; Raina, Vivek B.; Jasper, Angela M.; Rogers, Cody M.; Li, Wenjing; Zhou, Shuo; Mojidra, Rahul; Kwon, Youngho; Fang, Qingming; Ji, Jae-Hoon; Shabestari, Aida Badamchi; Fitzgerald, O'Taveon; Dinh, Hoang; Mukherjee, Bipasha; Habib, Amyn A.; Hromas, Robert; Mazin, Alexander V.; Wasmuth, Elizabeth V.; Olsen, Shaun K.; Libich, David S.; Zhou, Daohong; Zhao, Weixing; Greene, Eric C.; Burma, Sandeep; Sung, Patrick
  作者单位：University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; NewYork-Presbyterian Hospital; Columbia University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas at San Antonio; University of Michigan System; University of Michigan
  摘要：The licensing step of DNA double-strand break repair by homologous recombination entails resection of DNA ends to generate a single-stranded DNA template for assembly of the repair machinery consisting of the RAD51 recombinase and ancillary factors(1). DNA end resection is mechanistically intricate and reliant on the tumour suppressor complex BRCA1-BARD1 (ref. (2)). Specifically, three distinct nuclease entities-the 5-3 ' exonuclease EXO1 and heterodimeric complexes of the DNA endonuclease DNA...
• Continuously fluctuating selection reveals fine granularity of adaptation AI翻译
  作者：Bitter, M. C.; Berardi, S.; Oken, H.; Huynh, A.; Lappo, Egor; Schmidt, P.; Petrov, D. A.
  作者单位：Stanford University; University of Pennsylvania; Chan Zuckerberg Initiative (CZI)
  摘要：Temporally fluctuating environmental conditions are a ubiquitous feature of natural habitats. Yet, how finely natural populations adaptively track fluctuating selection pressures via shifts in standing genetic variation is unknown1,2. Here we generated genome-wide allele frequency data every 1-2 generations from a genetically diverse population of Drosophila melanogaster in extensively replicated field mesocosms from late June to mid-December (a period of approximately 12 total generations). A...
• How to keep a president healthy - tips from a former White House doctor AI翻译
  作者：Hundal, Henna
  作者单位：Stanford University
  摘要：From quitting smoking to dealing with anthrax, a fascinating memoir looks behind the scenes at presidential health care.
• Can AI have common sense? Finding out will be key to achieving machine intelligence AI翻译
  作者：Kejriwal, Mayank; Santos, Henrique; Mulvehill, Alice M.; Shen, Ke; McGuinness, Deborah L.; Lieberman, Henry
  作者单位：University of Southern California; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Massachusetts Institute of Technology (MIT)
  摘要：The advent of LLMs has reopened a debate about the limits of machine intelligence - and requires new benchmarks of what reasoning consists of.