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作者：Flayer, Cameron H.; Kernin, Isabela J.; Matatia, Peri R.; Zeng, Xiangsunze; Yarmolinsky, David A.; Han, Cai; Naik, Parth R.; Buttaci, Dean R.; Aderhold, Pamela A.; Camire, Ryan B.; Zhu, Xueping; Tirard, Alice J.; McGuire, John T.; Smith, Neal P.; McKimmie, Clive S.; McAlpine, Cameron S.; Swirski, Filip K.; Woolf, Clifford J.; Villani, Alexandra-Chloe; Sokol, Caroline L.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of York - UK; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：In naive individuals, sensory neurons directly detect and respond to allergens, leading to both the sensation of itch and the activation of local innate immune cells, which initiate the allergic immune response1,2. In the setting of chronic allergic inflammation, immune factors prime sensory neurons, causing pathologic itch3-7. Although these bidirectional neuroimmune circuits drive responses to allergens, whether immune cells regulate the set-point for neuronal activation by allergens in the ...
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作者：Yang, Chuyu; Mammen, Lorenz; Kim, Byoungsoo; Li, Meng; Robson, Drew N.; Li, Jennifer M.
作者单位：Max Planck Society; Eberhard Karls University of Tubingen; Cornell University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS
摘要：Spatial learning in teleost fish requires an intact telencephalon(1), a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus)(2-4). However, cells fundamental to spatial cognition in mammals-for example, place cells (PCs)(5,6)-have yet to be established in any fish species. In this study, using tracking microscopy to record brain-wide calcium activity in freely swimming larval zebrafish(7), we compute the spatial information conte...
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作者：Shin, Mingyu; Chang, Eunji; Lee, Daewon; Kim, Nayun; Cho, Bumsik; Cha, Nuri; Koranteng, Ferdinand; Song, Ji-Joon; Shim, Jiwon
作者单位：Hanyang University; Korea Advanced Institute of Science & Technology (KAIST); Hanyang University; Hanyang University; Hanyang University
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作者：Burman, Nathaniel; Belukhina, Svetlana; Depardieu, Florence; Wilkinson, Royce A.; Skutel, Mikhail; Santiago-Frangos, Andrew; Graham, Ava B.; Livenskyi, Alexei; Chechenina, Anna; Morozova, Natalia; Zahl, Trevor; Henriques, William S.; Buyukyoruk, Murat; Rouillon, Christophe; Saudemont, Baptiste; Shyrokova, Lena; Kurata, Tatsuaki; Hauryliuk, Vasili; Severinov, Konstantin; Groseille, Justine; Thierry, Agnes; Koszul, Romain; Tesson, Florian; Bernheim, Aude; Bikard, David; Wiedenheft, Blake; Isaev, Artem
作者单位：Montana State University System; Montana State University Bozeman; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Russian Academy of Sciences; Institute of Gene Biology (IGB) of Russian Academy of Sciences; Lomonosov Moscow State University; Peter the Great St. Petersburg Polytechnic University; Lund University; Lund University; Rutgers University System; Rutgers University New Brunswick
摘要：Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites1. The phage antirestriction induced system (PARIS) is a defence system, often encoded in viral genomes, that is composed of a 55 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB)2. However, the mechanism by which AriA and AriB function in phage defence is unknown. Here we show that AriA and AriB assemble into a 425 kDa supramolecular...
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作者：Lakshmikanth, Tadepally; Consiglio, Camila; Sardh, Fabian; Forlin, Rikard; Wang, Jun; Tan, Ziyang; Barcenilla, Hugo; Rodriguez, Lucie; Sugrue, Jamie; Noori, Peri; Ivanchenko, Margarita; Paez, Laura Pinero; Gonzalez, Laura; Mugabo, Constantin Habimana; Johnsson, Anette; Ryberg, Henrik; Hallgren, Asa; Pou, Christian; Chen, Yang; Mikes, Jaromir; James, Anna; Dahlqvist, Per; Wahlberg, Jeanette; Hagelin, Anders; Holmberg, Mats; Degerblad, Marie; Isaksson, Magnus; Duffy, Darragh; Kampe, Olle; Landegren, Nils; Brodin, Petter
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作者：Chandler, Jo
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作者：Dibley, Arjuna; Burdon, Rebecca; Self, Alister; Lewis, Jared; Meinshausen, Malte; Guetschow, Johannes; Pflueger, Mika; Busch, Daniel; Neville, Ben
作者单位：University of Melbourne; University of Melbourne; University of Melbourne
摘要：Private-investor approaches for measuring the emissions associated with lending to governments risk creating perverse incentives.
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作者：Shimajiri, Takuya; Kawaguchi, Soki; Suzuki, Takanori; Ishigaki, Yusuke
作者单位：Hokkaido University; Hokkaido University; University of Tokyo
摘要：Covalent bonds share electron pairs between two atoms and make up the skeletons of most organic compounds in single, double and triple bonds. In contrast, examples of one-electron bonds remain scarce, most probably due to their intrinsic weakness1-4. Although several pioneering studies have reported one-electron bonds between heteroatoms, direct evidence for one-electron bonds between carbon atoms remains elusive. Here we report the isolation of a compound with a one-electron sigma-bond betwee...
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作者：Dethier, Evan Nylen
作者单位：Colby College
摘要：The jury has been out on whether global warming will increase the erosion of riverbanks in the Arctic - with consequences for human infrastructure and the environment. A detailed analysis of an Alaskan river suggests that it will.
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作者：Rader, Daniel J.; Creasy, Kate Townsend
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Can cycles of dieting increase your risk of heart attack? In mice, an alternating high-fat and low-fat diet promotes plaque build-up in arteries by modulating the body's innate immune responses.
