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作者：Al Zubaydi, Samir; Waske, Shivam; Akyildiz, Volkan; Starbuck, Hunter F.; Majumder, Mayukh; Moore, Curtis E.; Kalyani, Dipannita; Sevov, Christo S.
作者单位：University System of Ohio; Ohio State University; Ataturk University; Merck & Company; Merck & Company USA
摘要：The selective cross-coupling of two alkyl electrophiles to construct complex molecules remains a challenge in organic synthesis1,2. Known reactions are optimized for specific electrophiles and are not amenable to interchangeably varying electrophilic substrates that are sourced from common alkyl building blocks, such as amines, carboxylic acids and halides3-5. These limitations restrict the types of alkyl substrate that can be modified and, ultimately, the chemical space that can be explored6....
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作者：Diana, Zoie T.; Rochman, Chelsea M.; Mallos, Nicholas
作者单位：University of Toronto
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作者：Pannone, Andrew; Raj, Aditya; Ravichandran, Harikrishnan; Das, Sarbashis; Chen, Ziheng; Price, Collin A.; Sultana, Mahmooda; Das, Saptarshi
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
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作者：Hadas, Ron; Rubinstein, Hernan; Mittnenzweig, Markus; Mayshar, Yoav; Ben-Yair, Raz; Cheng, Saifeng; Aguilera-Castrejon, Alejandro; Reines, Netta; Orenbuch, Ayelet-Hashahar; Lifshitz, Aviezer; Chen, Dong-Yuan; Elowitz, Michael B.; Zernicka-Goetz, Magdalena; Hanna, Jacob H.; Tanay, Amos; Stelzer, Yonatan
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; California Institute of Technology; University of Cambridge
摘要：The developing placenta, which in mice originates through the extraembryonic ectoderm (ExE), is essential for mammalian embryonic development. Yet unbiased characterization of the differentiation dynamics of the ExE and its interactions with the embryo proper remains incomplete. Here we develop a temporal single-cell model of mouse gastrulation that maps continuous and parallel differentiation in embryonic and extraembryonic lineages. This is matched with a three-way perturbation approach to t...
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作者：Katz, Mark A.; Sawyer, Edith M.; Oriolt, Luke; Kozlova, Albina; Williams, Madison C.; Margolis, Shally R.; Johnson, Matthew; Bondy-Denomy, Joseph; Meeske, Alexander J.
作者单位：University of Washington; University of Washington Seattle; University of California System; University of California San Francisco
摘要：Prokaryotic CRISPR-Cas immunity is subverted by anti-CRISPRs (Acrs), which inhibit Cas protein activities when expressed during the phage lytic cycle or from resident prophages or plasmids1. Acrs often bind to specific cognate Cas proteins, and hence inhibition is typically limited to a single CRISPR-Cas subtype2. Furthermore, although acr genes are frequently organized together in phage-associated gene clusters3, how such inhibitors initially evolve has remained unclear. Here we investigated ...
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作者：Feng, Bing; Bai, Zhiliang; Zhou, Xiaolei; Zhao, Yang; Xie, Yu-Qing; Huang, Xinyi; Liu, Yang; Enbar, Tom; Li, Rongrong; Wang, Yi; Gao, Min; Bonati, Lucia; Peng, Mei-Wen; Li, Weilin; Tao, Bo; Charmoy, Melanie; Held, Werner; Melenhorst, J. Joseph; Fan, Rong; Guo, Yugang; Tang, Li
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; University of Lausanne; Cleveland Clinic Foundation; Zhejiang University; Zhejiang University; Zhejiang University
摘要：Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon(1,2). A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1-centric immunotherapy to achieve enduring response against cancer(3,4). Here we show that an interleukin-4 fusion protein (Fc-IL-4), a typical type 2 cytokine, directly acts on CD8(+) T cells and enriches functional terminally exhausted CD...
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作者：Sidik, Saima
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作者：[Anonymous]
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作者：Mosleh, Mohsen; Yang, Qi; Zaman, Tauhid; Pennycook, Gordon; Rand, David G.
作者单位：University of Oxford; University of Exeter; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Yale University; Cornell University; Massachusetts Institute of Technology (MIT)
摘要：In response to intense pressure, technology companies have enacted policies to combat misinformation(1-4). The enforcement of these policies has, however, led to technology companies being regularly accused of political bias(5-7). We argue that differential sharing of misinformation by people identifying with different political groups(8-15) could lead to political asymmetries in enforcement, even by unbiased policies. We first analysed 9,000 politically active Twitter users during the US 2020...
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作者：Aidukas, Tomas; Phillips, Nicholas W.; Diaz, Ana; Poghosyan, Emiliya; Muller, Elisabeth; Levi, A. F. J.; Aeppli, Gabriel; Guizar-Sicairos, Manuel; Holler, Mirko
