2024

最新文章

• Don't blame search engines for sending users to unreliable sites AI翻译
  作者：[Anonymous]
• Chromatin remodelling drives immune cell-fibroblast communication in heart failure AI翻译
  作者：Alexanian, Michael; Padmanabhan, Arun; Nishino, Tomohiro; Travers, Joshua G.; Ye, Lin; Pelonero, Angelo; Lee, Clara Youngna; Sadagopan, Nandhini; Huang, Yu; Auclair, Kirsten; Zhu, Ada; An, Yuqian; Ekstrand, Christina A.; Martinez, Cassandra; Teran, Barbara Gonzalez; Flanigan, Will R.; Kim, Charis Kee-Seon; Lumbao-Conradson, Koya; Gardner, Zachary; Li, Li; Costa, Mauro W.; Jain, Rajan; Charo, Israel; Combes, Alexis J.; Haldar, Saptarsi M.; Pollard, Katherine S.; Vagnozzi, Ronald J.; Mckinsey, Timothy A.; Przytycki, Pawel F.; Srivastava, Deepak
  作者单位：University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Boston University; University of California System; University of California San Francisco
  摘要：Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel maladaptive cell state transitions1 and pathological interaction between cellular compartments. Although chronic fibroblast activation worsens dysfunction in the lungs, liver, kidneys and heart, and exacerbates many cancers2, the stress-sensing mechanisms initiatin...
• Chinese scientists say funding shake-up has made it harder to win grants AI翻译
  作者：Conroy, Gemma
• Why we are all lab rats in the digital world AI翻译
  作者：Weiss, Tim
• Neuropeptide signalling orchestrates T cell differentiation AI翻译
  作者：Hou, Yu; Sun, Linyu; LaFleur, Martin W.; Huang, Linglin; Lambden, Conner; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn; Kimura, Kimitoshi; Yan, Longjun; Zang, Yue; Tang, Ruihan; Shi, Jingwen; Barilla, Rocky; Deng, Liwen; Subramanian, Ayshwarya; Wallrapp, Antonia; Choi, Hee Sun; Kye, Yoon-Chul; Ashenberg, Orr; Schiebinger, Geoffrey; Doench, John G.; Chiu, Isaac M.; Regev, Aviv; Sharpe, Arlene H.; Kuchroo, Vijay K.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Liangzhu Laboratory; Zhejiang University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Sun Yat Sen University; University of British Columbia; Roche Holding; Roche Holding USA; Genentech
  摘要：The balance between T helper type 1 (TH1) cells and other TH cells is critical for antiviral and anti-tumour responses1-3, but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of TH1 cell differentiation during in vitro polarization, and during in vivo differentiation after acute viral infection. We identified regulators modulating T helper cell differentiation using a unique TH1-TH2 cell dichotomous culture system and systematically validated th...
• The origins of animal embryonic development AI翻译
  作者：Brunet, Thibaut
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
• AI-generated images threaten science - here's how researchers hope to spot them AI翻译
  作者：Kwon, Diana
• Task-agnostic exoskeleton control via biological joint moment estimation AI翻译
  作者：Molinaro, Dean D.; Scherpereel, Keaton L.; Schonhaut, Ethan B.; Evangelopoulos, Georgios; Shepherd, Max K.; Young, Aaron J.
  作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Northeastern University; Northeastern University; Alphabet Inc.; Google Incorporated
  摘要：Lower-limb exoskeletons have the potential to transform the way we move1-14, but current state-of-the-art controllers cannot accommodate the rich set of possible human behaviours that range from cyclic and predictable to transitory and unstructured. We introduce a task-agnostic controller that assists the user on the basis of instantaneous estimates of lower-limb biological joint moments from a deep neural network. By estimating both hip and knee moments in-the-loop, our approach provided mult...
• Engineered odorant receptors illuminate the basis of odour discrimination AI翻译
  作者：de March, Claire A.; Ma, Ning; Billesbolle, Christian B.; Tewari, Jeevan; del Torrent, Claudia Llinas; van der Velden, Wijnand J. C.; Ojiro, Ichie; Takayama, Ikumi; Faust, Bryan; Li, Linus; Vaidehi, Nagarajan; Manglik, Aashish; Matsunami, Hiroaki
  作者单位：Duke University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); City of Hope; Beckman Research Institute of City of Hope; University of California System; University of California San Francisco; University of Barcelona; Autonomous University of Barcelona; University of Shizuoka; Tokyo University of Agriculture & Technology; University of California System; University of California San Francisco; Duke University
  摘要：How the olfactory system detects and distinguishes odorants with diverse physicochemical properties and molecular configurations remains poorly understood. Vertebrate animals perceive odours through G protein-coupled odorant receptors (ORs)1. In humans, around 400 ORs enable the sense of smell. The OR family comprises two main classes: class I ORs are tuned to carboxylic acids whereas class II ORs, which represent most of the human repertoire, respond to a wide variety of odorants2. A fundamen...
• Fluorspar to fluorochemicals upon low-temperature activation in water AI翻译
  作者：Klose, Immo; Patel, Calum; Mondal, Anirban; Schwarz, Andrew; Pupo, Gabriele; Gouverneur, Veronique
  作者单位：University of Oxford
  摘要：The dangerous chemical hydrogen fluoride sits at the apex of the fluorochemical industry, but the substantial hazards linked to its production under harsh conditions (above 300 degrees Celsius) and transport are typically contracted to specialists. All fluorochemicals for applications, including refrigeration, electric transportation, agrochemicals and pharmaceuticals, are prepared from fluorspar (CaF2) through a procedure that generates highly dangerous hydrogen fluoride1-5. Here we report a ...