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作者:[Anonymous]
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作者:Cai, Xintong; Liu, Changliang; Tsutsui-Kimura, Iku; Lee, Joon-Hyuk; Guo, Chong; Banerjee, Aditi; Lee, Jinoh; Amo, Ryunosuke; Xie, Yudi; Patriarchi, Tommaso; Li, Yulong; Watabe-Uchida, Mitsuko; Uchida, Naoshige; Kaeser, Pascal S.
作者单位:Harvard University; Harvard Medical School; Harvard University; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Peking University
摘要:Dopamine signalling modes differ in kinetics and spatial patterns of receptor activation1,2. How these modes contribute to motor function, motivation and learning has long been debated3-21. Here we show that action-potential-induced dopamine release is dispensable for movement initiation but supports reward-oriented behaviour. We generated mice with dopamine-neuron-specific knockout of the release site organizer protein RIM to disrupt action-potential-induced dopamine release. In these mice, r...
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作者:Dance, Amber
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作者:Stokes, Alexander J.; Vary, Nick G.; Lorshbough, Erika L.
作者单位:University of Hawaii System
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作者:Wang, Anqi; Breakwell, Charlotte; Foglia, Fabrizia; Tan, Rui; Lovell, Louie; Wei, Xiaochu; Wong, Toby; Meng, Naiqi; Li, Haodong; Seel, Andrew; Sarter, Mona; Smith, Keenan; Alvarez-Fernandez, Alberto; Furedi, Mate; Guldin, Stefan; Britton, Melanie M.; McKeown, Neil B.; Jelfs, Kim E.; Song, Qilei
作者单位:Imperial College London; Imperial College London; University of London; University College London; University of Birmingham; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; University of London; Royal Holloway University London; University of London; University College London; University of Edinburgh; King Abdullah University of Science & Technology
摘要:Ion-conducting polymer membranes are essential in many separation processes and electrochemical devices, including electrodialysis1, redox flow batteries2, fuel cells3 and electrolysers4,5. Controlling ion transport and selectivity in these membranes largely hinges on the manipulation of pore size. Although membrane pore structures can be designed in the dry state6, they are redefined upon hydration owing to swelling in electrolyte solutions. Strategies to control pore hydration and a deeper u...
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作者:Ly, Jimmy; Xiang, Kehui; Su, Kuan-Chung; Sissoko, Gunter B.; Bartel, David P.; Cheeseman, Iain M.
作者单位:Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
摘要:Regulated start-codon selection has the potential to reshape the proteome through the differential production of upstream open reading frames, canonical proteins, and alternative translational isoforms1-3. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide translation-initiation-site profiling4, we reveal a global increase in the stringency of start-codon selection during mammalian mitosis. Low-efficiency initiation sites are ...
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作者:Reich, Peter B.; Mohanbabu, Neha; Isbell, Forest; Hobbie, Sarah E.; Butler, Ethan E.
作者单位:University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Western Sydney University; University of Minnesota System; University of Minnesota Twin Cities
摘要:Rising levels of atmospheric carbon dioxide (CO2) and nitrogen (N) deposition affect plant communities in numerous ways(1-11). Nitrogen deposition causes local biodiversity loss globally(12-14), but whether, and if so how, rising CO2 concentrations amplify or dampen those losses remains unclear and is almost entirely unstudied. We addressed this knowledge gap with an open-air experiment in which 108 grassland plots were grown for 24 years under different CO2 and N regimes. We initially found t...
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作者:Stoffel, Markus; Corona, Christophe; St George, Scott
作者单位:University of Geneva; Centre National de la Recherche Scientifique (CNRS)
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作者:Flavin, Matthew T.; Ha, Kyoung-Ho; Guo, Zengrong; Li, Shupeng; Kim, Jin-Tae; Saxena, Tara; Simatos, Dimitrios; Al-Najjar, Fatimah; Mao, Yuxuan; Bandapalli, Shishir; Fan, Chengye; Bai, Dongjun; Zhang, Zhuang; Zhang, Yanlin; Flavin, Eunhye; Madsen, Kenneth E.; Huang, Yi; Emu, Luoqian; Zhao, Jingyang; Yoo, Jae-Young; Park, Minsu; Shin, Jaeho; Huang, Aaron G.; Shin, Hee-Sup; Colgate, J. Edward; Huang, Yonggang; Xie, Zhaoqian; Jiang, Hanqing; Rogers, John A.
作者单位:University System of Georgia; Georgia Institute of Technology; Northwestern University; Westlake University; Northwestern University; Pohang University of Science & Technology (POSTECH); Northwestern University; Shanghai Jiao Tong University; Dalian University of Technology; Dalian University of Technology; Dalian University of Technology; University System of Georgia; Georgia Institute of Technology; University of Illinois System; University of Illinois Urbana-Champaign; Sungkyunkwan University (SKKU); Dankook University; Korea Institute of Science & Technology (KIST); Northwestern University; Northwestern University; Westlake University; Westlake University; Northwestern University; Feinberg School of Medicine
摘要:The rich set of mechanoreceptors found in human skin1,2 offers a versatile engineering interface for transmitting information and eliciting perceptions3,4, potentially serving a broad range of applications in patient care5 and other important industries6,7. Targeted multisensory engagement of these afferent units, however, faces persistent challenges, especially for wearable, programmable systems that need to operate adaptively across the body8-11. Here we present a miniaturized electromechani...
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作者:Vierinen, Juha
作者单位:UiT The Arctic University of Tromso