2024

最新文章

• For sale: baby shoes, worn way too often AI翻译
  作者：Pettit, M. J.
• 'A big, big win': plan to pay for wildlife conservation emerges at biodiversity summit AI翻译
  作者：Taylor, Luke
• 'We need to be ready for a new world': scientists globally react to Trump election win AI翻译
  作者：Tollefson, Jeff
• China's thriving forests are stockpiling vast amounts of carbon AI翻译
  作者：[Anonymous]
• Calcium-permeable AMPA receptors govern PV neuron feature selectivity AI翻译
  作者：Hong, Ingie; Kim, Juhyun; Hainmueller, Thomas; Kim, Dong Won; Keijser, Joram; Johnson, Richard C.; Park, Soo Hyun; Limjunyawong, Nathachit; Yang, Zhuonan; Cheon, David; Hwang, Taeyoung; Agarwal, Amit; Cholvin, Thibault; Krienen, Fenna M.; McCarroll, Steven A.; Dong, Xinzhong; Leopold, David A.; Blackshaw, Seth; Sprekeler, Henning; Bergles, Dwight E.; Bartos, Marlene; Brown, Solange P.; Huganir, Richard L.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Korea Brain Research Institute (KBRI); University of Freiburg; Technical University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); Korea Advanced Institute of Science & Technology (KAIST); Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Ruprecht Karls University Heidelberg; Princeton University; Harvard University; Harvard Medical School; Johns Hopkins University; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University; NYU Langone Medical Center; New York University; Aarhus University; Aarhus University; Mahidol University
  摘要：The brain helps us survive by forming internal representations of the external world(1,2). Excitatory cortical neurons are often precisely tuned to specific external stimuli(3,4). However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective5. PV interneurons differ from excitatory neurons in their neurotransmitter receptor subtypes, including AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs)(6,7). Excitatory neurons exp...
• Human hippocampal and entorhinal neurons encode the temporal structure of experience AI翻译
  作者：Tacikowski, Pawel; Kalender, Guldamla; Ciliberti, Davide; Fried, Itzhak
  作者单位：University of California System; University of California Los Angeles; Karolinska Institutet; Universidade de Coimbra; University of California System; University of California Los Angeles; Tel Aviv University; University of Minnesota System; University of Minnesota Twin Cities; Otto von Guericke University
  摘要：Extracting the underlying temporal structure of experience is a fundamental aspect of learning and memory that allows us to predict what is likely to happen next. Current knowledge about the neural underpinnings of this cognitive process in humans stems from functional neuroimaging research1-5. As these methods lack direct access to the neuronal level, it remains unknown how this process is computed by neurons in the human brain. Here we record from single neurons in individuals who have been ...
• Myocardial infarction augments sleep to limit cardiac inflammation and damage AI翻译
  作者：Huynh, Pacific; Hoffmann, Jan D.; Gerhardt, Teresa; Kiss, Mate G.; Zuraikat, Faris M.; Cohen, Oren; Wolfram, Christopher; Yates, Abi G.; Leunig, Alexander; Heiser, Merlin; Gaebel, Lena; Gianeselli, Matteo; Goswami, Sukanya; Khamhoung, Annie; Downey, Jeffrey; Yoon, Seonghun; Chen, Zhihong; Roudko, Vladimir; Dawson, Travis; Ferreira da Silva, Joana; Ameral, Natalie J.; Morgenroth-Rebin, Jarod; D'Souza, Darwin; Koekkoek, Laura L.; Jacob, Walter; Munitz, Jazz; Lee, Donghoon; Fullard, John F.; van Leent, Mandy M. T.; Roussos, Panos; Kim-Schulze, Seunghee; Shah, Neomi; Kleinstiver, Benjamin P.; Swirski, Filip K.; Leistner, David; St-Onge, Marie-Pierre; McAlpine, Cameron S.
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; German Heart Center Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Goethe University Frankfurt; Goethe University Frankfurt Hospital
  摘要：Sleep is integral to cardiovascular health1,2. Yet, the circuits that connect cardiovascular pathology and sleep are incompletely understood. It remains unclear whether cardiac injury influences sleep and whether sleep-mediated neural outputs contribute to heart healing and inflammation. Here we report that in humans and mice, monocytes are actively recruited to the brain after myocardial infarction (MI) to augment sleep, which suppresses sympathetic outflow to the heart, limiting inflammation...
• Structural basis of archaeal FttA-dependent transcription termination AI翻译
  作者：You, Linlin; Wang, Chengyuan; Molodtsov, Vadim; Kuznedelov, Konstantin; Miao, Xinyi; Wenck, Breanna R.; Ulisse, Paul; Sanders, Travis J.; Marshall, Craig J.; Firlar, Emre; Kaelber, Jason T.; Santangelo, Thomas J.; Ebright, Richard H.
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Colorado State University System; Colorado State University Fort Collins; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick
  摘要：The ribonuclease FttA (also known as aCPSF and aCPSF1) mediates factor-dependent transcription termination in archaea1-3. Here we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4, Spt5 and a transcription elongation complex (TEC). The structure shows that FttA interacts with the TEC in a manner that enables RNA to proceed directly from the TEC RNA-exit channel to the FttA catalytic centre and that enables endonucleolytic cleavage o...
• Will AI's huge energy demands spur a nuclear renaissance? AI翻译
  作者：Castelvecchi, Davide
  摘要：Contracts with Google and Amazon could help, but bringing new types of reactor online will take larger investments - and time.
• Western science diplomacy must rethink its biases AI翻译
  作者：Hussein, Hussam; Awad, Abdullah
  作者单位：University of Oxford