作者：Redenti, Andrew; Im, Jongwon; Redenti, Benjamin; Li, Fangda; Rouanne, Mathieu; Sheng, Zeren; Sun, William; Gurbatri, Candice R.; Huang, Shunyu; Komaranchath, Meghna; Jang, Younguk; Hahn, Jaeseung; Ballister, Edward R.; Vincent, Rosa L.; Vardoshivilli, Ana; Danino, Tal; Arpaia, Nicholas
作者单位：Columbia University; Columbia University; Columbia University; Columbia University
摘要：Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo1,2. With emerging evidence that bacteria naturally home in on tumours3,4 and modulate antitumour immunity5,6, one promising application is the development of bacterial vectors as precision cancer vaccines2,7. Here we engineered probiotic Escherichia coli Nissle 1917 as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays, wit...
作者：Skoulidis, Ferdinandos; Araujo, Haniel A.; Minh Truong Do; Qian, Yu; Sun, Xin; Cobo, Ana Galan; Le, John T.; Montesion, Meagan; Palmer, Rachael; Jahchan, Nadine; Juan, Joseph M.; Min, Chengyin; Yu, Yi; Pan, Xuewen; Arbour, Kathryn C.; Vokes, Natalie; Schmidt, Stephanie T.; Molkentine, David; Owen, Dwight H.; Memmott, Regan; Patil, Pradnya D.; Marmarelis, Melina E.; Awad, Mark M.; Murray, Joseph C.; Hellyer, Jessica A.; Gainor, Justin F.; Dimou, Anastasios; Bestvina, Christine M.; Shu, Catherine A.; Riess, Jonathan W.; Blakely, Collin M.; Pecot, Chad, V; Mezquita, Laura; Tabbo, Fabrizio; Scheffler, Matthias; Digumarthy, Subba; Mooradian, Meghan J.; Sacher, Adrian G.; Lau, Sally C. M.; Saltos, Andreas N.; Rotow, Julia; Johnson, Rocio Perez; Liu, Corinne; Stewart, Tyler; Goldberg, Sarah B.; Killam, Jonathan; Walther, Zenta; Schalper, Kurt; Davies, Kurtis D.; Woodcock, Mark G.; Anagnostou, Valsamo; Marrone, Kristen A.; Forde, Patrick M.; Ricciuti, Biagio; Venkatraman, Deepti; Van Allen, Eliezer M.; Cummings, Amy L.; Goldman, Jonathan W.; Shaish, Hiram; Kier, Melanie; Katz, Sharyn; Aggarwal, Charu; Ni, Ying; Azok, Joseph T.; Segal, Jeremy; Ritterhouse, Lauren; Neal, Joel W.; Lacroix, Ludovic; Elamin, Yasir Y.; Negrao, Marcelo, V; Le, Xiuning; Lam, Vincent K.; Lewis, Whitney E.; Kemp, Haley N.; Carter, Brett; Roth, Jack A.; Swisher, Stephen; Lee, Richard; Zhou, Teng; Poteete, Alissa; Kong, Yifan; Takehara, Tomohiro; Paula, Alvaro Guimaraes; Cuentas, Edwin R. Parra; Behrens, Carmen; Wistuba, Ignacio I.; Zhang, Jianjun; Blumenschein, George R.; Gay, Carl; Byers, Lauren A.; Gibbons, Don L.; Tsao, Anne; Lee, J. Jack; Bivona, Trever G.; Camidge, D. Ross; Gray, Jhannelle E.; Lieghl, Natasha; Levy, Benjamin; Brahmer, Julie R.; Garassino, Marina C.; Gandara, David R.; Garon, Edward B.; Rizvi, Naiyer A.; Scagliotti, Giorgio Vittorio; Wolf, Jurgen; Planchard, David; Besse, Benjamin; Herbst, Roy S.; Wakelee, Heather A.; Pennell, Nathan A.; Shaw, Alice T.; Janne, Pasi A.; Carbone, David P.; Hellmann, Matthew D.; Rudin, Charles M.; Albacker, Lee; Mann, Helen; Zhu, Zhou; Lai, Zhongwu; Stewart, Ross; Peters, Solange; Johnson, Melissa L.; Wong, Kwok K.; Huang, Alan; Winslow, Monte M.; Rosen, Michael J.; Winters, Ian P.; Papadimitrakopoulou, Vassiliki A.; Cascone, Tina; Jewsbury, Philip; Heymach, John, V
作者单位：University of Texas System; UTMD Anderson Cancer Center; Foundation Medicine; Memorial Sloan Kettering Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; Cleveland Clinic Foundation; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Johns Hopkins University; Johns Hopkins Medicine; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Mayo Clinic; University of Chicago; Columbia University; University of California System; University of California Davis; University of California System; University of California San Francisco; University of North Carolina; University of North Carolina Chapel Hill; University of Barcelona; Hospital Clinic de Barcelona; University of Cologne; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; H Lee Moffitt Cancer Center & Research Institute; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Diego; Yale University; Northwell Health; North Shore University Hospital; Yale University; University of Colorado System; University of Colorado Anschutz Medical Campus; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Icahn School of Medicine at Mount Sinai; University of Chicago; UNICANCER; Gustave Roussy; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado Denver; University of Turin; Novartis; Novartis USA; AstraZeneca; AstraZeneca; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Tennessee Oncology; Sarah Cannon Research Institute; Pfizer; Pfizer USA
摘要：For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity and immune-related toxicities, when compared with treatment with PD-(L)1 inhibitors alone. However, there are currently no validated biomarkers to identify which patients will benefit from dual ICB1,2. Here we show that patients with NSCLC who have mutations...
作者：Chiappe, Luis M.; Navalon, Guillermo; Martinelli, Agustin G.; Carvalho, Ismar de Souza; Miloni Santucci, Rodrigo; Wu, Yun-Hsin; Field, Daniel J.
作者单位：University of Cambridge; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); Universidade Federal do Rio de Janeiro; Universidade de Coimbra; Universidade de Brasilia; University of Cambridge
摘要：A dearth of Mesozoic-aged, three-dimensional fossils hinders understanding of the origin of the distinctive skull and brain of modern (crown) birds1. Here we report Navaornis hestiae gen. et sp. nov., an exquisitely preserved fossil species from the Late Cretaceous of Brazil. The skull of Navaornis is toothless and large-eyed, with a vaulted cranium closely resembling the condition in crown birds; however, phylogenetic analyses recover Navaornis in Enantiornithes, a highly diverse clade of Mes...
作者：Jans, Maude; Kolata, Magdalena; Blancke, Gillian; D'Hondt, Aline; Graf, Claudia; Ciers, Maarten; Sze, Mozes; Thiran, Alexandra; Petta, Ioanna; Andries, Vanessa; Verbandt, Sara; Shokry, Engy; Sumpton, David; Vande Voorde, Johan; Berx, Geert; Tejpar, Sabine; van Loo, Geert; Iliev, Iliyan D.; Remaut, Han; Vereecke, Lars
作者单位：Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; Ghent University; Vrije Universiteit Brussel; Flanders Institute for Biotechnology (VIB); Ghent University; KU Leuven; University of Glasgow; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
摘要：Various bacteria are suggested to contribute to colorectal cancer (CRC) development1-5, including pks+Escherichia coli, which produces the genotoxin colibactin that induces characteristic mutational signatures in host epithelial cells6. However, it remains unclear how the highly unstable colibactin molecule is able to access host epithelial cells to cause harm. Here, using the microbiota-dependent ZEB2-transgenic mouse model of invasive CRC7, we demonstrate that the oncogenic potential of pks+...
作者：Yang, Hongbin; Zhou, Yinong; Miao, Guangyao; Rusz, Jan; Yan, Xingxu; Guzman, Francisco; Xu, Xiaofeng; Xu, Xianghan; Aoki, Toshihiro; Zeiger, Paul; Zhu, Xuetao; Wang, Weihua; Guo, Jiandong; Wu, Ruqian; Pan, Xiaoqing
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; Uppsala University; Princeton University; University of California System; University of California Irvine
摘要：The remarkable increase in superconducting transition temperature (T-c) observed at the interface of one-unit-cell FeSe films on SrTiO3 substrates (1 uc FeSe/STO)(1) has attracted considerable research into the interface effects(2-6). Although this high T-c is thought to be associated with electron-phonon coupling (EPC)(2), the microscopic coupling mechanism and its role in the superconductivity remain elusive. Here we use momentum-selective high-resolution electron energy loss spectroscopy to...
作者：Smith, Jamie; Kast, Anton; Geraschenko, Anton; Morton, Y. Jade; Brenner, Michael P.; van Diggelen, Frank; Williams, Brian P.
作者单位：Alphabet Inc.; Google Incorporated; University of Colorado System; University of Colorado Boulder; Harvard University
摘要：The ionosphere is a layer of weakly ionized plasma bathed in Earth's geomagnetic field extending about 50-1,500 kilometres above Earth1. The ionospheric total electron content varies in response to Earth's space environment, interfering with Global Satellite Navigation System (GNSS) signals, resulting in one of the largest sources of error for position, navigation and timing services2. Networks of high-quality ground-based GNSS stations provide maps of ionospheric total electron content to cor...
