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作者：Yanai, Itai; Haas, Simon; Lippert, Christoph; Kretzmer, Helene
作者单位：NYU Langone Medical Center; NYU Langone Medical Center; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; University of London; Queen Mary University London; University of Potsdam; Icahn School of Medicine at Mount Sinai; Max Planck Society
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作者：Pernas, Lena
作者单位：University of California System; University of California Los Angeles; Howard Hughes Medical Institute
摘要：How do mitochondria, the cell's energy-producing organelles, perform competing metabolic processes? Segregation into distinct populations - one that makes energy-storing ATP molecules and one that does not - could explain it.
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作者：Li, Dong; Xiao, Yu; Fedorova, Iana; Xiong, Weijia; Wang, Yu; Liu, Xi; Huiting, Erin; Ren, Jie; Gao, Zirui; Zhao, Xingyu; Cao, Xueli; Zhang, Yi; Bondy-Denomy, Joseph; Feng, Yue
作者单位：Beijing University of Chemical Technology; Chinese Academy of Sciences; Tsinghua University; University of California System; University of California San Francisco; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; University of California System; University of California San Francisco
摘要：Prokaryotic anti-phage immune systems use TIR and cGAS-like enzymes to produce 1 ''-3 '-glycocyclic ADP- ribose (1 ''-3 '-gcADPR) and cyclic dinucleotide (CDN) and cyclic trinucleotide (CTN) signalling molecules, respectively, which limit phage replication(1-3). However, how phages neutralize these distinct and common systems is largely unclear. Here we show that the Thoeris anti-defence proteins Tad1(4) and Tad2(5) both achieve anti-cyclic-oligonucleotide-based anti-phage signalling system (a...
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作者：Dance, Amber
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作者：[Anonymous]
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作者：Ocon, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; Lajevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E.; Huang, Mian; Handel, Tracy; Dawson, John R. D.; Kufareva, Irina; Zabel, Brian A.; Pan, Junliang; Butcher, Eugene C.
作者单位：Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System; University of Verona; University of Verona; University of California System; University of California San Diego
摘要：Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon and skin are known1,2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues remain poorly understood. Here we leveraged diverse omics datasets to identify GPR25 as a lymphocyte recep...
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作者：Kudiabor, Helena
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作者：Redekop, Evgeny; Zhang, Canxun; Park, Heonjoon; Cai, Jiaqi; Anderson, Eric; Sheekey, Owen; Arp, Trevor; Babikyan, Grigory; Salters, Samuel; Watanabe, Kenji; Taniguchi, Takashi; Huber, Martin E.; Xu, Xiaodong; Young, Andrea F.
作者单位：University of California System; University of California Santa Barbara; University of Washington; University of Washington Seattle; National Institute for Materials Science; National Institute for Materials Science; University of Colorado System; University of Colorado Denver; University of Washington; University of Washington Seattle
摘要：Orbital magnetization provides a sensitive probe of topology and interactions, with particularly rich phenomenology in Chern insulators in which the topological edge states carry large equilibrium currents. Here we use a nanoscale superconducting sensor1,2 to map the magnetic fringe fields in twisted bilayers of MoTe2, in which transport3,4 and optical sensing5,6 experiments have revealed the formation of fractional Chern insulator (FCI) states at zero magnetic field. We observe oscillations i...
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作者：He, Zhisong; Dony, Leander; Fleck, Jonas Simon; Szalata, Artur; Li, Katelyn X.; Sliskovic, Irena; Lin, Hsiu-Chuan; Santel, Malgorzata; Atamian, Alexander; Quadrato, Giorgia; Sun, Jieran; Pasca, Sergiu P.; Camp, J. Gray; Theis, Fabian J.; Treutlein, Barbara
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; Technical University of Munich; Roche Holding; Technical University of Munich; University of Southern California; University of Southern California; Stanford University; University of Basel
摘要：Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to study human brain development, evolution and disease. However, it is unclear which parts of the human brain are covered by existing protocols, and it has been difficult to quantitatively assess organoid variation and fidelity. Here we integrate 36 single-cell transcriptomic datasets spanning 26 protocols into one integrated human neural organoid cell atlas totalling more than 1.7 million cells1-26. Mapp...
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作者：Callaway, Ewen
摘要：The code underlying the Nobel-prize-winning tool for modelling protein structures can now be downloaded by academics.
