作者：Sun, Wenfei; Liu, Zhihui; Jiang, Xian; Chen, Michelle B.; Dong, Hua; Liu, Jonathan; Sudhof, Thomas C.; Quake, Stephen R.
作者单位：Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Memory encodes past experiences, thereby enabling future plans. The basolateral amygdala is a centre of salience networks that underlie emotional experiences and thus has a key role in long-term fear memory formation1. Here we used spatial and single-cell transcriptomics to illuminate the cellular and molecular architecture of the role of the basolateral amygdala in long-term memory. We identified transcriptional signatures in subpopulations of neurons and astrocytes that were memory-specific ...
作者：Zhong, Donglai; Wu, Can; Jiang, Yuanwen; Yuan, Yujia; Kim, Min-gu; Nishio, Yuya; Shih, Chien-Chung; Wang, Weichen; Lai, Jian-Cheng; Ji, Xiaozhou; Gao, Theodore Z.; Wang, Yi-Xuan; Xu, Chengyi; Zheng, Yu; Yu, Zhiao; Gong, Huaxin; Matsuhisa, Naoji; Zhao, Chuanzhen; Lei, Yusheng; Liu, Deyu; Zhang, Song; Ochiai, Yuto; Liu, Shuhan; Wei, Shiyuan; Tok, Jeffrey B. -H.; Bao, Zhenan
作者单位：Stanford University; Stanford University; Stanford University; Tianjin University; Stanford University; Yonsei University; Yonsei University Health System; National Yunlin University Science & Technology; University of Tokyo
摘要：Intrinsically stretchable electronics with skin-like mechanical properties have been identified as a promising platform for emerging applications ranging from continuous physiological monitoring to real-time analysis of health conditions, to closed-loop delivery of autonomous medical treatment1-7. However, current technologies could only reach electrical performance at amorphous-silicon level (that is, charge-carrier mobility of about 1 cm2 V-1 s-1), low integration scale (for example, 54 tran...
作者：DaRosa, Paul A.; Penchev, Ivan; Gumbin, Samantha C.; Scavone, Francesco; Wachalska, Magda; Paulo, Joao A.; Ordureau, Alban; Peter, Joshua J.; Kulathu, Yogesh; Harper, J. Wade; Becker, Thomas; Beckmann, Roland; Kopito, Ron R.
作者单位：Stanford University; University of Munich; Harvard University; Harvard Medical School; University of Dundee; Memorial Sloan Kettering Cancer Center
摘要：Reversible modification of target proteins by ubiquitin and ubiquitin-like proteins (UBLs) is widely used by eukaryotic cells to control protein fate and cell behaviour(1). UFM1 is a UBL that predominantly modifies a single lysine residue on a single ribosomal protein, uL24 (also called RPL26), on ribosomes at the cytoplasmic surface of the endoplasmic reticulum (ER)(2,3). UFM1 conjugation (UFMylation) facilitates the rescue of 60S ribosomal subunits (60S) that are released after ribosome-asso...
作者：Bick, Alexander G.; Metcalf, Ginger A.; Mayo, Kelsey R.; Lichtenstein, Lee; Rura, Shimon; Carroll, Robert J.; Musick, Anjene; Linder, Jodell E.; Jordan, I. King; Nagar, Shashwat Deepali; Sharma, Shivam; Meller, Robert; Basford, Melissa; Boerwinkle, Eric; Cicek, Mine S.; Doheny, Kimberly F.; Eichler, Evan E.; Gabriel, Stacey; Gibbs, Richard A.; Glazer, David; Harris, Paul A.; Jarvik, Gail P.; Philippakis, Anthony; Rehm, Heidi L.; Roden, Dan M.; Thibodeau, Stephen N.; Topper, Scott; Blegen, Ashley L.; Wirkus, Samantha J.; Wagner, Victoria A.; Meyer, Jeffrey G.; Cicek, Mine S.; Muzny, Donna M.; Metcalf, Ginger A.; Venner, Eric; Mawhinney, Michelle Z.; Griffith, Sean M. L.; Hsu, Elvin; Ling, Hua; Adams, Marcia K.; Walker, Kimberly; Hu, Jianhong; Doddapaneni, Harsha; Kovar, Christie L.; Murugan, Mullai; Dugan, Shannon; Khan, Ziad; Boerwinkle, Eric; Lennon, Niall J.; Austin-Tse, Christina; Banks, Eric; Gatzen, Michael; Gupta, Namrata; Henricks, Emma; Larsson, Katie; McDonough, Sheli; Harrison, Steven M.; Kachulis, Christopher; Lebo, Matthew S.; Neben, Cynthia L.; Steeves, Marcie; Zhou, Alicia Y.; Smith, Joshua D.; Frazar, Christian D.; Davis, Colleen P.; Patterson, Karynne E.; Wheeler, Marsha M.; McGee, Sean; Lockwood, Christina M.; Shirts, Brian H.; Pritchard, Colin C.; Murray, Mitzi L.; Vasta, Valeria; Leistritz, Dru; Richardson, Matthew A.; Buchan, Jillian G.; Radhakrishnan, Aparna; Krumm, Niklas; Ehmen, Brenna W.; Schwartz, Sophie; Aster, M. Morgan T.; Cibulskis, Kristian; Haessly, Andrea; Asch, Rebecca; Cremer, Aurora; Degatano, Kylee; Shergill, Akum; Gauthier, Laura D.; Lee, Samuel K.; Hatcher, Aaron; Grant, George B.; Brandt, Genevieve R.; Covarrubias, Miguel; Banks, Eric; Able, Ashley; Green, Ashley E.; Carroll, Robert J.; Zhang, Jennifer; Condon, Henry R.; Wang, Yuanyuan; Dillon, Moira K.; Albach, C. H.; Baalawi, Wail; Choi, Seung Hoan; Wang, Xin; Ramirez, Andrea H.; Lim, Sokny; Nambiar, Siddhartha; Ozenberger, Bradley; Wise, Anastasia L.; Lunt, Chris; Ginsburg, Geoffrey S.; Denny, Joshua C.
作者单位：Vanderbilt University; Baylor College of Medicine; Vanderbilt University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Vanderbilt University; National Institutes of Health (NIH) - USA; University System of Georgia; Georgia Institute of Technology; Morehouse School of Medicine; Mayo Clinic; Johns Hopkins University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Washington; University of Washington Seattle; Vanderbilt University; Vanderbilt University; Mayo Clinic; University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; University of Washington; University of Washington Seattle
摘要：Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics1-4. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health5,6. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 7...
