2024

最新文章

• The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons AI翻译
  作者：Makhlouf, Linda; Peter, Joshua J.; Magnussen, Helge M.; Thakur, Rohan; Millrine, David; Minshull, Thomas C.; Harrison, Grace; Varghese, Joby; Lamoliatte, Frederic; Foglizzo, Martina; Macartney, Thomas; Calabrese, Antonio N.; Zeqiraj, Elton; Kulathu, Yogesh
  作者单位：University of Leeds; University of Dundee
  摘要：Stalled ribosomes at the endoplasmic reticulum (ER) are covalently modified with the ubiquitin-like protein UFM1 on the 60S ribosomal subunit protein RPL26 (also known as uL24)(1,2). This modification, which is known as UFMylation, is orchestrated by the UFM1 ribosome E3 ligase (UREL) complex, comprising UFL1, UFBP1 and CDK5RAP3 (ref. (3)). However, the catalytic mechanism of UREL and the functional consequences of UFMylation are unclear. Here we present cryo-electron microscopy structures of ...
• 11 reasons why we've stayed in academia AI翻译
  作者：Landhuis, Esther; Yee, Daryl; Claw, Katrina; Schweppe, Devin; Singh, Ankur; Macklin, Paul; Moore, Jonathan; Fertig, Elana; Lee, Myungjae; Zhong, Yu; Garmire, Lana; Zurzolo, Chiara
  摘要：Although many postdocs and faculty members are leaving for industry or elsewhere, these researchers tell us why they love the academic life.
• Embrace AI to break down barriers in publishing for people who aren't fluent in English AI翻译
  作者：Santos, Charles Morphy D.; Gois, Joao Paulo
  作者单位：Universidade Federal do ABC (UFABC)
  摘要：Letter to the Editor
• 3D printing enables mass production of microcomponents AI翻译
  作者：Spiegel, Christoph A.; Blasco, Eva
  作者单位：Ruprecht Karls University Heidelberg
  摘要：Combining a high-throughput technique with 3D printing offers a way of fabricating micrometre-sized particles for use in electronics and biotechnology. The versatile method can produce one million intricate shapes in a single day.
• Four change-makers seek impact in medical research AI翻译
  作者：Coombs, Amy; Ong, Sandy
• Activation of Thoeris antiviral system via SIR2 effector filament assembly AI翻译
  作者：Tamulaitiene, Giedre; Sabonis, Dziugas; Sasnauskas, Giedrius; Ruksenaite, Audrone; Silanskas, Arunas; Avraham, Carmel; Ofir, Gal; Sorek, Rotem; Zaremba, Mindaugas; Siksnys, Virginijus
  作者单位：Vilnius University; Weizmann Institute of Science
  摘要：To survive bacteriophage (phage) infections, bacteria developed numerous anti-phage defence systems(1-7). Some of them (for example, type III CRISPR-Cas, CBASS, Pycsar and Thoeris) consist of two modules: a sensor responsible for infection recognition and an effector that stops viral replication by destroying key cellular components(8-12). In the Thoeris system, a Toll/interleukin-1 receptor (TIR)-domain protein, ThsB, acts as a sensor that synthesizes an isomer of cyclic ADP ribose, 1 '-3 ' g...
• Why sunsets were a weird colour after Krakatau blew its top AI翻译
  作者：[Anonymous]
• Brazil's record dengue surge: why a vaccine campaign is unlikely to stop it AI翻译
  作者：Lenharo, Mariana
• Drought triggers and sustains overnight fires in North America AI翻译
  作者：Luo, Kaiwei; Wang, Xianli; de Jong, Mark; Flannigan, Mike
  作者单位：University of Alberta; Natural Resources Canada; Canadian Forest Service; Natural Resources Canada; Canadian Forest Service; Great Lakes Forestry Centre; Thompson Rivers University
  摘要：Overnight fires are emerging in North America with previously unknown drivers and implications. This notable phenomenon challenges the traditional understanding of the 'active day, quiet night' model of the diurnal fire cycle1-3 and current fire management practices4,5. Here we demonstrate that drought conditions promote overnight burning, which is a key mechanism fostering large active fires. We examined the hourly diurnal cycle of 23,557 fires and identified 1,095 overnight burning events (O...
• B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 AI翻译
  作者：Afzali, Ali Maisam; Nirschl, Lucy; Sie, Christopher; Pfaller, Monika; Ulianov, Oleksii; Hassler, Tobias; Federle, Christine; Petrozziello, Elisabetta; Kalluri, Sudhakar Reddy; Chen, Hsin Hsiang; Tyystjaervi, Sofia; Muschaweckh, Andreas; Lammens, Katja; Delbridge, Claire; Buettner, Andreas; Steiger, Katja; Seyhan, Goenuel; Ottersen, Ole Petter; OEllinger, Rupert; Rad, Roland; Jarosch, Sebastian; Straub, Adrian; Muehlbauer, Anton; Grassmann, Simon; Hemmer, Bernhard; Boettcher, Jan P.; Wagner, Ingrid; Kreutzfeldt, Mario; Merkler, Doron; Pardas, Irene Bonafonte; Schmidt Supprian, Marc; Buchholz, Veit R.; Heink, Sylvia; Busch, Dirk H.; Klein, Ludger; Korn, Thomas
  作者单位：Technical University of Munich; Technical University of Munich; University of Munich; University of Munich; University of Munich; Technical University of Munich; Technical University of Munich; University of Rostock; Technical University of Munich; University of Oslo; Technical University of Munich; Technical University of Munich; Memorial Sloan Kettering Cancer Center; Technical University of Munich; University of Geneva; German Center for Infection Research
  摘要：Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen(1). The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP4(2). However, the T cell response that is required for the generation of these anti-AQP4 antibodies is not well understood. Here we show that B cells endogenously express AQP4 in response to activation with anti-CD40 and IL-21 and are able to present their...