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作者：Wild, Sarah
摘要：An analysis of DOIs suggests that digital preservation is not keeping up with burgeoning scholarly knowledge.
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作者：Witze, Alexandra
摘要：But some are now challenging the vote, saying there were 'procedural irregularities'.
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作者：[Anonymous]
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作者：Cappelluti, Martino Alfredo; Poeta, Valeria Mollica; Valsoni, Sara; Quarato, Piergiuseppe; Merlin, Simone; Merelli, Ivan; Lombardo, Angelo
作者单位：Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Eastern Piedmont Amedeo Avogadro; Consiglio Nazionale delle Ricerche (CNR); Istituto di Tecnologie Biomediche (ITB-CNR); Vita-Salute San Raffaele University
摘要：Permanent epigenetic silencing using programmable editors equipped with transcriptional repressors holds great promise for the treatment of human diseases1-3. However, to unlock its full therapeutic potential, an experimental confirmation of durable epigenetic silencing after the delivery of transient delivery of editors in vivo is needed. To this end, here we targeted Pcsk9, a gene expressed in hepatocytes that is involved in cholesterol homeostasis. In vitro screening of different editor des...
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作者：Na, Neil; Lu, Yen-Cheng; Liu, Yu-Hsuan; Chen, Po-Wei; Lai, Ying-Chen; Lin, You-Ru; Lin, Chung-Chih; Shia, Tim; Cheng, Chih-Hao; Chen, Shu-Lu
摘要：The ability to detect single photons has led to the advancement of numerous research fields(1-11). Although various types of single-photon detector have been developed(12), because of two main factors-that is, (1) the need for operating at cryogenic temperature(13,14) and (2) the incompatibility with complementary metal-oxide-semiconductor (CMOS) fabrication processes(15,16)-so far, to our knowledge, only Si-based single-photon avalanche diode (SPAD)(17,18) has gained mainstream success and ha...
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作者：Lemke, Greg
作者单位：Salk Institute
摘要：Neuroscientist who discovered how the brain controls releasing hormones.
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作者：Bedard, Antoine; Blouin, Simon; Cheng, Sihao
作者单位：University of Warwick; University of Victoria; Institute for Advanced Study - USA
摘要：White dwarfs are stellar remnants devoid of a nuclear energy source, gradually cooling over billions of years(1,2) and eventually freezing into a solid state from the inside out(3,4). Recently, it was discovered that a population of freezing white dwarfs maintains a constant luminosity for a duration comparable with the age of the universe(5), signalling the presence of a powerful, yet unknown, energy source that inhibits the cooling. For certain core compositions, the freezing process is pred...
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作者：Kronenfeld, Jason M.; Rother, Lukas; Saccone, Max A.; Dulay, Maria T.; DeSimone, Joseph M.
作者单位：Stanford University; Stanford University; Stanford University
摘要：Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering1,2, drug and vaccine delivery3-5, microfluidics6,7, granular systems8,9, self-assembly5,10,11, microelectronics12,13 and abrasives14. Herein we introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics i...
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作者：Mangurian, Christina; Brindis, Claire D.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Without action, parity is still half a century away. We cannot afford to wait that long.
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作者：Sherwin, Evan D.; Rutherford, Jeffrey S.; Zhang, Zhan; Chen, Yuanlei; Wetherley, Erin B.; Yakovlev, Petr V.; Berman, Elena S. F.; Jones, Brian B.; Cusworth, Daniel H.; Thorpe, Andrew K.; Ayasse, Alana K.; Duren, Riley M.; Brandt, Adam R.
作者单位：Stanford University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of Arizona; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：As airborne methane surveys of oil and gas systems continue to discover large emissions that are missing from official estimates1-4, the true scope of methane emissions from energy production has yet to be quantified. We integrate approximately one million aerial site measurements into regional emissions inventories for six regions in the USA, comprising 52% of onshore oil and 29% of gas production over 15 aerial campaigns. We construct complete emissions distributions for each, employing empi...
