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作者：Telford, Max; Hejnol, Andreas; Arendt, Detlev
作者单位：University of London; University College London; Friedrich Schiller University of Jena; European Molecular Biology Laboratory (EMBL)
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作者：Weng, Chen; Yu, Fulong; Yang, Dian; Poeschla, Michael; Liggett, L. Alexander; Jones, Matthew G.; Qiu, Xiaojie; Wahlster, Lara; Caulier, Alexis; Hussmann, Jeffrey A.; Schnell, Alexandra; Yost, Kathryn E.; Koblan, Luke W.; Martin-Rufino, Jorge D.; Min, Joseph; Hammond, Alessandro; Ssozi, Daniel; Bueno, Raphael; Mallidi, Hari; Kreso, Antonia; Escabi, Javier; Rideout, William M.; Jacks, Tyler; Hormoz, Sahand; van Galen, Peter; Weissman, Jonathan S.; Sankaran, Vijay G.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Massachusetts Institute of Technology (MIT); Whitehead Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Guangzhou Medical University; State Key Laboratory of Respiratory Disease; Columbia University; Stanford University
摘要：The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs)1. Perturbations to this process underlie diverse diseases, but the clonal contributions to human haematopoiesis and how this changes with age remain incompletely understood. Although recent insights have emerged from barcoding studies in model systems2-5, simultaneous detection of cell states and phylogenies from natural barcodes in human...
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作者：[Anonymous]
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作者：Xu, Bingxin; Chen, Zaijun; Haensch, Theodor W.; Picque, Nathalie
作者单位：Max Planck Society; University of Munich; Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; University of Southern California
摘要：Ultraviolet spectroscopy provides unique insights into the structure of matter with applications ranging from fundamental tests to photochemistry in the Earth's atmosphere and astronomical observations from space telescopes(1-8). At longer wavelengths, dual-comb spectroscopy, using two interfering laser frequency combs, has become a powerful technique capable of simultaneously providing a broad spectral range and very high resolution(9). Here we demonstrate a photon-counting approach that can ...
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作者：Ollivier, Matthias; Soto, Joselyn S.; Linker, Kay E.; Moye, Stefanie L.; Jami-Alahmadi, Yasaman; Jones, Anthony E.; Divakaruni, Ajit S.; Kawaguchi, Riki; Wohlschlegel, James A.; Khakh, Baljit S.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Astrocytes are heterogeneous glial cells of the central nervous system(1-3). However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specific population of astrocytes in the central striatum expresses mu-crystallin (encoded by Crym in mice and CRYM in humans) that is associated with several human diseases, including neuropsychiatric disorders(4-7). In adult mice, reducing the levels of mu-crystallin in striatal astrocyt...
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作者：Nakandakari-Higa, Sandra; Walker, Sarah; Canesso, Maria C. C.; van der Heide, Verena; Chudnovskiy, Aleksey; Kim, Dong-Yoon; Jacobsen, Johanne T.; Parsa, Roham; Bilanovic, Jana; Parigi, S. Martina; Fiedorczuk, Karol; Fuchs, Elaine; Bilate, Angelina M.; Pasqual, Giulia; Mucida, Daniel; Kamphorst, Alice O.; Pritykin, Yuri; Victora, Gabriel D.
作者单位：Rockefeller University; Princeton University; Princeton University; Rockefeller University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Rockefeller University; Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; University of Padua; Princeton University; University of Oslo; National Hospital Norway
摘要：Immune cells rely on transient physical interactions with other immune and non-immune populations to regulate their function(1). To study these 'kiss-and-run' interactions directly in vivo, we previously developed LIPSTIC (labelling immune partnerships by SorTagging intercellular contacts)(2), an approach that uses enzymatic transfer of a labelled substrate between the molecular partners CD40L and CD40 to label interacting cells. Reliance on this pathway limited the use of LIPSTIC to measuring...
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作者：Wheeler, Michael A.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
摘要：Direct interactions between cells in tissue are incompletely understood because the advanced technologies required to examine them are still in their infancy. A new method can decipher cell-cell interactions on a large scale.
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作者：Wang, Chao; Tang, Ren-Jie; Kou, Senhao; Xu, Xiaoshu; Lu, Yi; Rauscher, Kenda; Voelker, Angela; Luan, Sheng
作者单位：University of California System; University of California Berkeley; Stanford University; University of California System; University of California Berkeley
摘要：Calcium (Ca2+) is an essential nutrient for plants and a cellular signal, but excessive levels can be toxic and inhibit growth1,2. To thrive in dynamic environments, plants must monitor and maintain cytosolic Ca2+ homeostasis by regulating numerous Ca2+ transporters3. Here we report two signalling pathways in Arabidopsis thaliana that converge on the activation of vacuolar Ca2+/H+ exchangers (CAXs) to scavenge excess cytosolic Ca2+ in plants. One mechanism, activated in response to an elevated...
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作者：Kruyer, Anna
作者单位：University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati
摘要：A single gene in astrocytes can constrain repetitive behaviours, indicating that these cells are regulators of behavioural disruption in conditions such as Huntington's disease and obsessive-compulsive disorder.
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作者：Kuan, Aaron T.; Bondanelli, Giulio; Driscoll, Laura N.; Han, Julie; Kim, Minsu; Hildebrand, David G. C.; Graham, Brett J.; Wilson, Daniel E.; Thomas, Logan A.; Panzeri, Stefano; Harvey, Christopher D.; Lee, Wei-Chung Allen
作者单位：Harvard University; Harvard Medical School; Istituto Italiano di Tecnologia - IIT; University of Hamburg; University Medical Center Hamburg-Eppendorf; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Yale University; Allen Institute for Brain Science; Rockefeller University; Space Telescope Science Institute; University of California System; University of California Berkeley
摘要：The posterior parietal cortex exhibits choice-selective activity during perceptual decision-making tasks(1-10). However, it is not known how this selective activity arises from the underlying synaptic connectivity. Here we combined virtual-reality behaviour, two-photon calcium imaging, high-throughput electron microscopy and circuit modelling to analyse how synaptic connectivity between neurons in the posterior parietal cortex relates to their selective activity. We found that excitatory pyram...
