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作者：Gupta, Nishma; Silke, John
作者单位：Melbourne Genomics Health Alliance
摘要：Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases.
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作者：Frayer, Megan E.; Coughlan, Jenn M.
作者单位：Yale University
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作者：Zeng, Yuan; Zhang, Hong-Wei; Wu, Xiao-Xian; Zhang, Yu
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Efficient termination is required for robust gene transcription. Eukaryotic organisms use a conserved exoribonuclease-mediated mechanism to terminate the mRNA transcription by RNA polymerase II (Pol II)(1-5). Here we report two cryogenic electron microscopy structures of Saccharomyces cerevisiae Pol II pre-termination transcription complexes bound to the 5'-to-3' exoribonuclease Rat1 and its partner Rai1. Our structures show that Rat1 displaces the elongation factor Spt5 to dock at the Pol II ...
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作者：Chase-Lubitz, Jesse
摘要：The island nation is expanding its territory by dredging up sediment from the ocean floor. But scientists, former government officials and activists say such reclamation can harm marine ecosystems and make the country more vulnerable to rising seas.
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作者：Kuklewicz, Jeremi; Zimmer, Jochen
作者单位：University of Virginia; University of Virginia; Howard Hughes Medical Institute
摘要：Capsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and pathogenic bacteria 1 . Through the ABC-transporter-dependent biosynthesis pathway, CPSs are synthesized intracellularly on a lipid anchor and secreted across the cell envelope by the KpsMT ABC transporter associated with the KpsE and KpsD subunits 1,2 . Here we use structural and functional studies to uncover crucial steps of CPS secretion in Gram-negative bacteria. We show that KpsMT has broad substrate specifi...
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作者：Li, Siyu; Harir, Mourad; Bastviken, David; Schmitt-Kopplin, Philippe; Gonsior, Michael; Enrich-Prast, Alex; Valle, Juliana; Hertkorn, Norbert
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Linkoping University; University System of Maryland; University of Maryland Center for Environmental Science; Universidade Federal de Sao Paulo (UNIFESP)
摘要：Dissolved organic matter (DOM) is one of the most complex, dynamic and abundant sources of organic carbon, but its chemical reactivity remains uncertain 1-3 . Greater insights into DOM structural features could facilitate understanding its synthesis, turnover and processing in the global carbon cycle 4,5 . Here we use complementary multiplicity-edited 13C nuclear magnetic resonance (NMR) spectra to quantify key substructures assembling the carbon skeletons of DOM from four main Amazon rivers a...
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Djellouli, Adel; Van Raemdonck, Bert; Wang, Yang; Yang, Yi; Caillaud, Anthony; Weitz, David; Rubinstein, Shmuel; Gorissen, Benjamin; Bertoldi, Katia
作者单位：Harvard University; KU Leuven; Hebrew University of Jerusalem
摘要：The pursuit of materials with enhanced functionality has led to the emergence of metamaterials-artificially engineered materials whose properties are determined by their structure rather than composition. Traditionally, the building blocks of metamaterials are arranged in fixed positions within a lattice structure(1-19). However, recent research has revealed the potential of mixing disconnected building blocks in a fluidic medium(20-27). Inspired by these recent advances, here we show that by ...
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作者：Mao, Fangyuan; Zhang, Chi; Ren, Jicheng; Wang, Tao; Wang, Guofu; Zhang, Fakui; Rich, Thomas; Vickers-Rich, Patricia; Meng, Jin
作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; American Museum of Natural History (AMNH); Monash University; Curtin University; City University of New York (CUNY) System
摘要：The dual jaw joint of Morganucodon(1,2) consists of the dentary-squamosal joint laterally and the articular-quadrate one medially. The articular-quadrate joint and its associated post-dentary bones constitute the precursor of the mammalian middle ear. Fossils documenting the transition from such a precursor to the mammalian middle ear are poor, resulting in inconsistent interpretations of this hallmark apparatus in the earliest stage of mammaliaform evolution(1-5). Here we report mandibular mi...
