2024

最新文章

• Smoking bans are coming: what does the evidence say? AI翻译
  作者：Wong, Carissa
  摘要：Countries are cracking down on tobacco use and vaping - the laws could save thousands of lives and billions of dollars, say scientists.
• Ancestral allele of DNA polymerase gamma modifies antiviral tolerance AI翻译
  作者：Kang, Yilin; Hepojoki, Jussi; Maldonado, Rocio Sartori; Mito, Takayuki; Terzioglu, Muegen; Manninen, Tuula; Kant, Ravi; Singh, Sachin; Othman, Alaa; Verma, Rohit; Uusimaa, Johanna; Wartiovaara, Kirmo; Kareinen, Lauri; Zamboni, Nicola; Nyman, Tuula Anneli; Paetau, Anders; Kipar, Anja; Vapalahti, Olli; Suomalainen, Anu
  作者单位：University of Helsinki; University of Helsinki; University of Zurich; University of Helsinki; Fahrenheit Universities; Medical University Gdansk; University of Oslo; University of Oslo; National Hospital Norway; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Oulu; University of Oulu; University of Helsinki; Helsinki University Central Hospital; Finnish Food Authority; University of Helsinki; University of Helsinki
  摘要：Mitochondria are critical modulators of antiviral tolerance through the release of mitochondrial RNA and DNA (mtDNA and mtRNA) fragments into the cytoplasm after infection, activating virus sensors and type-I interferon (IFN-I) response 1-4 . The relevance of these mechanisms for mitochondrial diseases remains understudied. Here we investigated mitochondrial recessive ataxia syndrome (MIRAS), which is caused by a common European founder mutation in DNA polymerase gamma (POLG1) 5 . Patients hom...
• Mid-ocean ridge unfaulting revealed by magmatic intrusions AI翻译
  作者：Olive, Jean-Arthur; Ekstrom, Goran; Buck, W. Roger; Liu, Zhonglan; Escartin, Javier; Bickert, Manon
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Columbia University; Jilin University; Universite de Bretagne Occidentale; Ifremer; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU)
  摘要：Mid-ocean ridges (MORs) are quintessential sites of tectonic extension1-4, at which divergence between lithospheric plates shapes abyssal hills that cover about two-thirds of the Earth's surface5,6. Here we show that tectonic extension at the ridge axis can be partially undone by tectonic shortening across the ridge flanks. This process is evidenced by recent sequences of reverse-faulting earthquakes about 15 km off-axis at the Mid-Atlantic Ridge and Carlsberg Ridge. Using mechanical models, w...
• High carrier mobility along the [111] orientation in Cu2O photoelectrodes AI翻译
  作者：Pan, Linfeng; Dai, Linjie; Burton, Oliver J.; Chen, Lu; Andrei, Virgil; Zhang, Youcheng; Ren, Dan; Cheng, Jinshui; Wu, Linxiao; Frohna, Kyle; Abfalterer, Anna; Yang, Terry Chien-Jen; Niu, Wenzhe; Xia, Meng; Hofmann, Stephan; Dyson, Paul J.; Reisner, Erwin; Sirringhaus, Henning; Luo, Jingshan; Hagfeldt, Anders; Graetzel, Michael; Stranks, Samuel D.
  作者单位：University of Cambridge; University of Cambridge; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Cambridge; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Cambridge; Nankai University; Uppsala University
  摘要：Solar fuels offer a promising approach to provide sustainable fuels by harnessing sunlight(1,2). Following a decade of advancement, Cu2O photocathodes are capable of delivering a performance comparable to that of photoelectrodes with established photovoltaic materials(3,4,5). However, considerable bulk charge carrier recombination that is poorly understood still limits further advances in performance(6). Here we demonstrate performance of Cu2O photocathodes beyond the state-of-the-art by explo...
• India's Chipko movement is a model for effective activism AI翻译
  作者：Prasanna, N. S.; Gudasalamani, Ravikanth
• Scientists discover first algae that can fix nitrogen - thanks to a tiny cell structure AI翻译
  作者：Wong, Carissa
  摘要：A newly discovered 'organelle' that converts nitrogen gas into a useful form could pave the way for engineered plants that require less fertilizer.
• Mechanical activation opens a lipid-lined pore in OSCA ion channels AI翻译
  作者：Han, Yaoyao; Zhou, Zijing; Jin, Ruitao; Dai, Fei; Ge, Yifan; Ju, Xisan; Ma, Xiaonuo; He, Sitong; Yuan, Ling; Wang, Yingying; Yang, Wei; Yue, Xiaomin; Chen, Zhongwen; Sun, Yadong; Corry, Ben; Cox, Charles D.; Zhang, Yixiao
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Victor Chang Cardiac Research Institute; University of New South Wales Sydney; Australian National University; ShanghaiTech University; Zhejiang University; Zhejiang University; University of New South Wales Sydney; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
  摘要：OSCA/TMEM63 channels are the largest known family of mechanosensitive channels1-3, playing critical roles in plant4-7 and mammalian8,9 mechanotransduction. Here we determined 44 cryogenic electron microscopy structures of OSCA/TMEM63 channels in different environments to investigate the molecular basis of OSCA/TMEM63 channel mechanosensitivity. In nanodiscs, we mimicked increased membrane tension and observed a dilated pore with membrane access in one of the OSCA1.2 subunits. In liposomes, we ...
• NASA SEEKS FRESH IDEAS FOR BRINGING MARS ROCKS TO EARTH AI翻译
  作者：Kulkarni, Sumeet
• AI TRACES MYSTERIOUS METASTATIC CANCERS TO THEIR SOURCE AI翻译
  作者：Mallapaty, Smriti
• An exploration of how the insect-wing hinge functions AI翻译
  作者：Deora, Tanvi
  摘要：The hinge enables insects to control their wing movements, but how it works is hard to study. Multidisciplinary research, using imaging and machine-learning methods, now sheds light on the mechanism that underlies its operation.