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作者:[Anonymous]
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作者:Brodie, Jedediah F.; Mohd-Azlan, Jayasilan; Chen, Cheng; Wearn, Oliver R.; Deith, Mairin C. M.; Ball, James G. C.; Slade, Eleanor M.; Burslem, David F. R. P.; Teoh, Shu Woan; Williams, Peter J.; Nguyen, An; Moore, Jonathan H.; Goetz, Scott J.; Burns, Patrick; Jantz, Patrick; Hakkenberg, Christopher R.; Kaszta, Zaneta M.; Cushman, Sam; Coomes, David; Helmy, Olga E.; Reynolds, Glen; Rodriguez, Jon Paul; Jetz, Walter; Luskin, Matthew Scott
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作者:Schevenels, Giel; Cabochette, Pauline; America, Michelle; Vandenborne, Arnaud; De Grande, Line; Guenther, Stefan; He, Liqun; Dieu, Marc; Christou, Basile; Vermeersch, Marjorie; Germano, Raoul F. V.; Perez-Morga, David; Renard, Patricia; Martin, Maud; Vanlandewijck, Michael; Betsholtz, Christer; Vanhollebeke, Benoit
作者单位:Max Planck Society; Uppsala University; University of Namur; Karolinska Institutet
摘要:Vertebrate organs require locally adapted blood vessels 1,2 . The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands-well-known blood-brain barrier maturation signals 3-5 . The control mechanism relies on Wnt7a/b-dependent expression of Mmp25, which we find is enriched in b...
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作者:Leeming, Jack
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作者:Vikesland, Peter J.
作者单位:Virginia Polytechnic Institute & State University
摘要:A technique called surface-enhanced Raman spectroscopy can detect tiny quantities of compounds in solution, but has been difficult to use for quantitative analysis. A digital approach involving nanoparticles suggests a way forward.
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作者:Blattner, Charlotte E.
作者单位:University of Bern; University of Bern
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作者:Sutton, Christine
摘要:Theoretical physicist saw his eponymous particle discovered after 48 years.
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作者:Wong, Carissa
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作者:Gu, Yisu; Bartolome-Casado, Raquel; Xu, Chuan; Bertocchi, Alice; Janney, Alina; Heuberger, Cornelia; Pearson, Claire F.; Teichmann, Sarah A.; Thornton, Emily E.; Powrie, Fiona
作者单位:University of Oxford; Kennedy Institute for Rheumatology; Wellcome Trust Sanger Institute; University of Oslo; National Hospital Norway; University of Cambridge; University of Oxford; University of Oxford; Roche Holding
摘要:The intestinal immune system is highly adapted to maintaining tolerance to the commensal microbiota and self-antigens while defending against invading pathogens(1,2). Recognizing how the diverse network of local cells establish homeostasis and maintains it in the complex immune environment of the gut is critical to understanding how tolerance can be re-established following dysfunction, such as in inflammatory disorders. Although cell and molecular interactions that control T regulatory (T-reg...
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作者:Robinson, Andrew