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作者：[Anonymous]
摘要：Paring down the astronomical complexity of the protein-folding problem, plus Isaac Newton's ambiguous use of the word 'axiom', in the weekly dip into Nature's archive.
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作者：Johnson, Alex G.; Mayer, Megan L.; Schaefer, Stefan L.; McNamara-Bordewick, Nora K.; Hummer, Gerhard; Kranzusch, Philip J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Max Planck Society; Goethe University Frankfurt; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis(1-3). Studies of human and mouse GSDM pores have revealed the functions and architectures of assemblies comprising 24 to 33 protomers(4-9), but the mechanism and evolutionary origin of membrane targeting and GSDM pore formation remain unknown. Here we determine a structure of a bacterial GSDM (bGSDM) pore and define a conserved mechanism of pore assembly. Eng...
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作者：Prillaman, McKenzie
摘要：Many researchers think that Wegovy and Ozempic should be taken for life, but myriad factors can force people off them.
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作者：Farrell, Jordan S.; Hwaun, Ernie; Dudok, Barna; Soltesz, Ivan
作者单位：Stanford University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Baylor College of Medicine
摘要：Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions(1, 2-3). Memory replay events, for example, occur during synchronous population events called sharp-wave ripples in the hippocampus while mice are in an 'offline' behavioural state, enabling cognitive mechanisms such as memory consolidation and planning(4, 5, 6, 7, 8, 9, 10-11). But how does the brain re-engage with the external world during this...
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作者：Reardon, Sara
摘要：The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells.
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作者：[Anonymous]
摘要：People who survived paediatric cancers age faster and are at higher risk of early death.
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作者：[Anonymous]
摘要：Astronomers spot the first planet outside the Solar System to boast a phenomenon reminiscent of a rainbow.
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作者：Whiten, Andrew
作者单位：University of St Andrews
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作者：Faherty, Jacqueline K.; Burningham, Ben; Gagne, Jonathan; Suarez, Genaro; Vos, Johanna M.; Merchan, Sherelyn Alejandro; Morley, Caroline V.; Rowland, Melanie; Lacy, Brianna; Kiman, Rocio; Caselden, Dan; Kirkpatrick, J. Davy; Meisner, Aaron; Schneider, Adam C.; Kuchner, Marc Jason; Gagliuffi, Daniella Carolina Bardalez; Beichman, Charles; Eisenhardt, Peter; Gelino, Christopher R.; Gharib-Nezhad, Ehsan; Gonzales, Eileen; Marocco, Federico; Rothermich, Austin James; Whiteford, Niall
作者单位：American Museum of Natural History (AMNH); University of Hertfordshire; Universite de Montreal; Trinity College Dublin; City University of New York (CUNY) System; Hunter College (CUNY); University of Texas System; University of Texas Austin; California Institute of Technology; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Amherst College; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); National Aeronautics & Space Administration (NASA); NASA Ames Research Center; California State University System; San Francisco State University; Cornell University; Cornell University
摘要：Beyond our Solar System, aurorae have been inferred from radio observations of isolated brown dwarfs(1,2). Within our Solar System, giant planets have auroral emission with signatures across the electromagnetic spectrum including infrared emission of H-3(+) and methane. Isolated brown dwarfs with auroral signatures in the radio have been searched for corresponding infrared features, but only null detections have been reported(3). CWISEP J193518.59-154620.3. (W1935 for short) is an isolated bro...
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作者：Li, Letao; Liu, Xilu; Yang, Shanshan; Li, Meijiao; Wu, Yanwei; Hu, Siqi; Wang, Wenjuan; Jiang, Amin; Zhang, Qianqian; Zhang, Junbing; Ma, Xiaoli; Hu, Junyan; Zhao, Qiaohong; Liu, Yubing; Li, Dong; Hu, Junjie; Yang, Chonglin; Feng, Wei; Wang, Xiaochen
作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Yunnan University; Yunnan University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Southern University of Science & Technology
摘要：Lysosomes are degradation and signalling centres crucial for homeostasis, development and ageing1. To meet diverse cellular demands, lysosomes remodel their morphology and function through constant fusion and fission2,3. Little is known about the molecular basis of fission. Here we identify HPO-27, a conserved HEAT repeat protein, as a lysosome scission factor in Caenorhabditis elegans. Loss of HPO-27 impairs lysosome fission and leads to an excessive tubular network that ultimately collapses....
