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作者：Poirson, Juline; Cho, Hanna; Dhillon, Akashdeep; Haider, Shahan; Imrit, Ahmad Zoheyr; Lam, Mandy Hiu Yi; Alerasool, Nader; Lacoste, Jessica; Mizan, Lamisa; Wong, Cassandra; Gingras, Anne-Claude; Schramek, Daniel; Taipale, Mikko
作者单位：University of Toronto; University of Toronto; University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute
摘要：Targeted protein degradation and stabilization are promising therapeutic modalities because of their potency, versatility and their potential to expand the druggable target space(1,2). However, only a few of the hundreds of E3 ligases and deubiquitinases in the human proteome have been harnessed for this purpose, which substantially limits the potential of the approach. Moreover, there may be other protein classes that could be exploited for protein stabilization or degradation(3-5), but there...
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作者：Gautam, Avishekh; Boyd, David F.; Nikhar, Sameer; Zhang, Ting; Siokas, Ioannis; Van de Velde, Lee-Ann; Gaevert, Jessica; Meliopoulos, Victoria; Thapa, Bikash; Rodriguez, Diego A.; Cai, Kathy Q.; Yin, Chaoran; Schnepf, Daniel; Beer, Julius; Deantoneo, Carly; Williams, Riley M.; Shubina, Maria; Livingston, Brandi; Zhang, Dingqiang; Andrake, Mark D.; Lee, Seungheon; Boda, Raghavender; Duddupudi, Anantha L.; Crawford, Jeremy Chase; Vogel, Peter; Loch, Christian; Schwemmle, Martin; Fritz, Lawrence C.; Schultz-Cherry, Stacey; Green, Douglas R.; Cuny, Gregory D.; Thomas, Paul G.; Degterev, Alexei; Balachandran, Siddharth
作者单位：Fox Chase Cancer Center; St Jude Children's Research Hospital; St Jude Children's Research Hospital; University of California System; University of California Santa Cruz; University of Houston System; University of Houston; Tufts University; University of Freiburg; St Jude Children's Research Hospital; Reaction Biology
摘要：Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome1-5 (ARDS), for which there are no effective pharmacological therapies. Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV infection6-8 and can potentially be targeted by receptor interacting protein kinase 3 (RIPK3) inhibitors. ...
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作者：Luers, Amy; Koomey, Jonathan; Masanet, Eric; Gaffney, Owen; Creutzig, Felix; Ferres, Juan Lavista; Horvitz, Eric
作者单位：Microsoft; University of California System; University of California Santa Barbara; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Technical University of Berlin; Technical University of Berlin; Microsoft
摘要：As artificial intelligence transforms the global economy, researchers need to explore scenarios to assess how it can help, rather than harm, the climate.
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作者：[Anonymous]
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作者：Chen, Xiaoyu; Birey, Fikri; Li, Min-Yin; Revah, Omer; Levy, Rebecca; Thete, Mayuri Vijay; Reis, Noah; Kaganovsky, Konstantin; Onesto, Massimo; Sakai, Noriaki; Hudacova, Zuzana; Hao, Jin; Meng, Xiangling; Nishino, Seiji; Huguenard, John; Pasca, Sergiu
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Emory University
摘要：Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions 1 . TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impair...
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作者：Darwin, Charles
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作者：Powell, Kendall
摘要：In Grenada, public-health researcher Lindonne Telesford tests a soil additive made from recycled glass that could help farmers adapt to climate change.
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作者：Lyu, Bosai; Chen, Jiajun; Wang, Sen; Lou, Shuo; Shen, Peiyue; Xie, Jingxu; Qiu, Lu; Mitchell, Izaac; Li, Can; Hu, Cheng; Zhou, Xianliang; Watanabe, Kenji; Taniguchi, Takashi; Wang, Xiaoqun; Jia, Jinfeng; Liang, Qi; Chen, Guorui; Li, Tingxin; Wang, Shiyong; Ouyang, Wengen; Hod, Oded; Ding, Feng; Urbakh, Michael; Shi, Zhiwen
作者单位：Shanghai Jiao Tong University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Wuhan University; Wuhan University; Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); National Institute for Materials Science; National Institute for Materials Science; Shanghai Jiao Tong University; Tel Aviv University; Tel Aviv University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
摘要：Van der Waals encapsulation of two-dimensional materials in hexagonal boron nitride (hBN) stacks is a promising way to create ultrahigh-performance electronic devices(1-4). However, contemporary approaches for achieving van der Waals encapsulation, which involve artificial layer stacking using mechanical transfer techniques, are difficult to control, prone to contamination and unscalable. Here we report the transfer-free direct growth of high-quality graphene nanoribbons (GNRs) in hBN stacks. ...
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作者：Huang, Jinlou; Li, Duo; Coulon, Frederic; Yang, Xiao Jin
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Qingdao University; Cranfield University; Peking University
摘要：Letter to the Editor
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作者：Roslund, Jonathan D.; Cingoez, Arman; Lunden, William D.; Partridge, Guthrie B.; Kowligy, Abijith S.; Roller, Frank; Sheredy, Daniel B.; Skulason, Gunnar E.; Song, Joe P.; Abo-Shaeer, Jamil R.; Boyd, Martin M.
摘要：Deployed optical clocks will improve positioning for navigational autonomy 1 , provide remote time standards for geophysical monitoring 2 and distributed coherent sensing 3 , allow time synchronization of remote quantum networks 4,5 and provide operational redundancy for national time standards. Although laboratory optical clocks now reach fractional inaccuracies below 10-18 (refs. 6,7 ), transportable versions of these high-performing clocks 8,9 have limited utility because of their size, env...
