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作者：Nordling, Linda
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作者：[Anonymous]
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作者：Tan, Han L.; Yin, Luping; Tan, Yuqi; Ivanov, Jessica; Plucinska, Kaja; Ilanges, Anoj; Herb, Brian R.; Wang, Putianqi; Kosse, Christin; Cohen, Paul; Lin, Dayu; Friedman, Jeffrey M.
作者单位：Rockefeller University; Howard Hughes Medical Institute; NYU Langone Medical Center; New York University; Stanford University; Rockefeller University; University System of Maryland; University of Maryland Baltimore
摘要：Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity of specific neural populations controlling appetite and metabolism(1). Leptin regulates food intake by inhibiting orexigenic agouti-related protein (AGRP) neurons and activating anorexigenic pro-opiomelanocortin (POMC) neurons(2). However, whereas AGRP neurons regulate food intake on a rapid time scale, acute activation of POMC neurons has only a minimal effect(3-5). This ha...
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作者：Gong, Hao; Sakaguchi, Yuriko; Suzuki, Tsutomu; Yanagisawa, Miho; Aida, Takuzo
作者单位：University of Tokyo; University of Tokyo; University of Tokyo; RIKEN
摘要：Although separation is entropically unfavourable, it is often essential for our life1,2. The separation of very similar macromolecules such as deoxyribonucleic acids (DNAs) and their single nucleotide variants is difficult but holds great advantage for the progress of life science3. Here we report that a particular liquid-liquid phase separation (LLPS) at a solid-liquid interface led to the partitioning of DNAs with nearly identical structures. We found this intriguing phenomenon when we did d...
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作者：Wang, Zhangyu; Du, Li
作者单位：University of Macau
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作者：Ananthaswamy, Anil
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作者：[Anonymous]
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作者：Vassallo, Christopher N.; Doering, Christopher R.; Laub, Michael T.
作者单位：Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
摘要：Host-pathogen conflicts are crucibles of molecular innovation1,2. Selection for immunity to pathogens has driven the evolution of sophisticated immunity mechanisms throughout biology, including in bacterial defence against bacteriophages3. Here we characterize the widely distributed anti-phage defence system CmdTAC, which provides robust defence against infection by the T-even family of phages4. Our results support a model in which CmdC detects infection by sensing viral capsid proteins, ultim...
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作者：Dai, Fan; Brown, Jerry; Xie, Zhenhua; Wang, Yi; Gong, Peng
作者单位：University of Hong Kong; University of California System; University of California Berkeley; University of Hong Kong
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作者：Lu, Zhaolian; Mo, Shanlan; Xie, Duo; Zhai, Xiangwei; Deng, Shanjun; Zhou, Kantian; Wang, Kun; Kang, Xueling; Zhang, Hao; Tong, Juanzhen; Hou, Liangzhen; Hu, Huijuan; Li, Xuefei; Zhou, Da; Lee, Leo Tsz On; Liu, Li; Zhu, Yaxi; Yu, Jing; Lan, Ping; Wang, Jiguang; He, Zhen; He, Xionglei; Hu, Zheng
作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; University of Macau; Sun Yat Sen University; Xiamen University; Xiamen University; University of Macau; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Hong Kong University of Science & Technology; Sun Yat Sen University
摘要：Unravelling the origin and evolution of precancerous lesions is crucial for effectively preventing malignant transformation, yet our current knowledge remains limited1, 2-3. Here we used a base editor-enabled DNA barcoding system4 to comprehensively map single-cell phylogenies in mouse models of intestinal tumorigenesis induced by inflammation or loss of the Apc gene. Through quantitative analysis of high-resolution phylogenies including 260,922 single cells from normal, inflamed and neoplasti...
