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作者:Mayassi, Toufic; Li, Chenhao; Segerstolpe, Asa; Brown, Eric M.; Weisberg, Rebecca; Nakata, Toru; Yano, Hiroshi; Herbst, Paula; Artis, David; Graham, Daniel B.; Xavier, Ramnik J.
作者单位:Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
摘要:The intestine is characterized by an environment in which host requirements for nutrient and water absorption are consequently paired with the requirements to establish tolerance to the outside environment. To better understand how the intestine functions in health and disease, large efforts have been made to characterize the identity and composition of cells from different intestinal regions(1-8). However, the robustness, nature of adaptability and extent of resilience of the transcriptional ...
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作者:Chaurasia, Anurag
作者单位:Indian Council of Agricultural Research (ICAR); ICAR - Indian Institute of Vegetable Research
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作者:de Leaniz, Carlos Garcia; Mouchlianitis, Foivos A.
作者单位:Universidade de Vigo
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作者:Rodrigues, Meghie
摘要:Four Latin American researchers reflect on their experiences bridging the gap between science and policy in the region.
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作者:Comfort, Nathaniel
作者单位:University of California System; University of California Berkeley; Johns Hopkins University
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作者:[Anonymous]
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作者:Yang, Ran; Hunker, Olivia; Wise, Marleigh; Bleichert, Franziska
作者单位:Yale University
摘要:Loading of replicative helicases is obligatory for the assembly of DNA replication machineries. The eukaryotic MCM2-7 replicative helicase motor is deposited onto DNA by the origin recognition complex (ORC) and co-loader proteins as a head-to-head double hexamer to license replication origins. Although extensively studied in budding yeast(1-4), the mechanisms of origin licensing in multicellular eukaryotes remain poorly defined. Here we use biochemical reconstitution and electron microscopy to...
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作者:Baker, Simon
摘要:Many of the solutions to global challenges are coming from this expanding field.
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作者:Crow, James Mitchell
摘要:Finding answers to climate problems - and the financial benefits this might bring - is driving advances.
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作者:Sundaram, Subramanian; Lee, Joshua H.; Bjorge, Isabel M.; Michas, Christos; Kim, Sudong; Lammers, Alex; Mano, Joao F.; Eyckmans, Jeroen; White, Alice E.; Chen, Christopher S.
作者单位:Boston University; Boston University; Harvard University; Universidade de Aveiro; Boston University; Boston University; Boston University
摘要:Natural tissues are composed of diverse cells and extracellular materials whose arrangements across several length scales-from subcellular lengths(1) (micrometre) to the organ scale(2) (centimetre)-regulate biological functions. Tissue-fabrication methods have progressed to large constructs, for example, through stereolithography(3) and nozzle-based bioprinting(4,5), and subcellular resolution through subtractive photoablation(6-8). However, additive bioprinting struggles with sub-nozzle/voxel...