2024

最新文章

• Digestive contents and food webs record the advent of dinosaur supremacy AI翻译
  作者：Qvarnstrom, Martin; Wernstrom, Joel Vikberg; Wawrzyniak, Zuzanna; Barbacka, Maria; Pacyna, Grzegorz; Gorecki, Artur; Ziaja, Jadwiga; Jarzynka, Agata; Owocki, Krzysztof; Sulej, Tomasz; Marynowski, Leszek; Pienkowski, Grzegorz; Ahlberg, Per E.; Niedzwiedzki, Grzegorz
  作者单位：Uppsala University; UiT The Arctic University of Tromso; University of Silesia in Katowice; Polish Academy of Sciences; W. Szafer Institute of Botany of the Polish Academy of Sciences; Jagiellonian University; Polish Academy of Sciences; Institute of Geological Sciences of the Polish Academy of Sciences; Polish Academy of Sciences; Institute of Paleobiology of the Polish Academy of Sciences; Polish Geological Institute - National Research Institute
  摘要：The early radiation of dinosaurs remains a complex and poorly understood evolutionary event(1-4). Here we use hundreds of fossils with direct evidence of feeding to compare trophic dynamics across five vertebrate assemblages that record this event in the Triassic-Jurassic succession of the Polish Basin (central Europe). Bromalites, fossil digestive products, increase in size and diversity across the interval, indicating the emergence of larger dinosaur faunas with new feeding patterns. Well-pr...
• Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer AI翻译
  作者：Sonke, Gabe S.; van Ommen-Nijhof, Annemiek; Wortelboer, Noor; van der Noort, Vincent; Swinkels, Astrid C. P.; Blommestein, Hedwig M.; Paez, Cristina Guerrero; Mol, Linda; Beeker, Aart; Beelen, Karin; Hamming, Lisanne C.; Heijns, Joan B.; Honkoop, Aafke H.; de Jong, Paul C.; van Rossum-Schornagel, Quirine C.; van Schaik-van de Mheen, Christa; Tol, Jolien; Tromp-van Driel, Cathrien S.; Vrijaldenhoven, Suzan; van Leeuwen-Stok, A. Elise; Konings, Inge R.; Jager, Agnes; de Jong, Paul C.
  作者单位：Netherlands Cancer Institute; Erasmus University Rotterdam; Erasmus MC; Erasmus MC Cancer Institute; Netherlands Cancer Institute; Erasmus University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam; Spaarne Hospital; Rijnstate Hospital; Medical Center Leeuwarden; Amphia Hospital; Isala Clinics; St. Antonius Hospital Utrecht; Franciscus Gasthuis; Meander Medisch Centrum; Jeroen Bosch Ziekenhuis; Gelre Hospitals; Medical Center Of Alkmaar; Vrije Universiteit Amsterdam; University of Amsterdam
  摘要：Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) in combination with endocrine therapy improve the outcomes of patients with hormone-receptor (HR)-positive, HER2-negative advanced breast cancer and can be used early as first-line treatment or deferred to second-line treatment(1-7). Randomized data comparing the use of CDK4/6i in the first- and second-line setting are lacking. The phase 3 SONIA trial (NCT03425838) randomized 1,050 patients who had not received previous therapy for advanced ...
• Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma AI翻译
  作者：Chen, Yu-Jung; Iyer, Swathi V.; Hsieh, David Chun-Cheng; Li, Buren; Elias, Harold K.; Wang, Tao; Li, Jing; Ganbold, Mungunsarnai; Lien, Michelle C.; Peng, Yu-Chun; Xie, Xuanhua P.; Jayewickreme, Chenura D.; van den Brink, Marcel R. M.; Brady, Sean F.; Lim, S. Kyun; Parada, Luis F.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Rockefeller University; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; National Institutes of Health (NIH) - USA; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; City of Hope; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Glioblastoma is incurable and in urgent need of improved therapeutics(1). Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death(2). G...
• Gamma frequency entrainment attenuates amyloid load and modifies microglia (vol 540, pg 230, 2016) AI翻译
  作者：Iaccarino, Hunter F.; Singer, Annabelle C.; Martorell, Anthony J.; Rudenko, Andrii; Gao, Fan; Gillingham, Tyler Z.; Mathys, Hansruedi; Seo, Jinsoo; Kritskiy, Oleg; Abdurrob, Fatema; Adaikkan, Chinnakkaruppan; Canter, Rebecca G.; Rueda, Richard; Brown, Emery N.; Boyden, Edward S.; Tsai, Li-Huei
• Large global-scale vegetation sensitivity to daily rainfall variability AI翻译
  作者：Feldman, Andrew F.; Konings, Alexandra G.; Gentine, Pierre; Cattry, Mitra; Wang, Lixin; Smith, William K.; Biederman, Joel A.; Chatterjee, Abhishek; Joiner, Joanna; Poulter, Benjamin
  作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; Stanford University; Columbia University; Indiana University System; Indiana University Indianapolis; University of Arizona; United States Department of Agriculture (USDA); National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
  摘要：Rainfall events are globally becoming less frequent but more intense under a changing climate, thereby shifting climatic conditions for terrestrial vegetation independent of annual rainfall totals(1-3). However, it remains uncertain how changes in daily rainfall variability are affecting global vegetation photosynthesis and growth(3-17). Here we use several satellite-based vegetation indices and field observations indicative of photosynthesis and growth, and find that global annual-scale veget...
• MCM double hexamer loading visualized with human proteins AI翻译
  作者：Weissmann, Florian; Greiwe, Julia F.; Puhringer, Thomas; Eastwood, Evelyn L.; Couves, Emma C.; Miller, Thomas C. R.; Diffley, John F. X.; Costa, Alessandro
  作者单位：Francis Crick Institute; Francis Crick Institute; University of Copenhagen
  摘要：Eukaryotic DNA replication begins with the loading of the MCM replicative DNA helicase as a head-to-head double hexamer at origins of DNA replication(1-3). Our current understanding of how the double hexamer is assembled by the origin recognition complex (ORC), CDC6 and CDT1 comes mostly from budding yeast. Here we characterize human double hexamer (hDH) loading using biochemical reconstitution and cryo-electron microscopy with purified proteins. We show that the human double hexamer engages D...
• Four game-changing researchers in materials science AI翻译
  作者：Hedley, Esme; Ong, Sandy
  摘要：These scientists are bringing fresh perspectives to solving the world's big challenges in materials.
• Better data sets won't solve the problem - we need AI for Africa to be developed in Africa AI翻译
  作者：Moorosi, Nyalleng
  摘要：Language models developed by big technology companies consistently underperform in African languages. It's time to focus on local solutions.
• Intermittent rate coding and cue-specific ensembles support working memory AI翻译
  作者：Panichello, Matthew F.; Jonikaitis, Donatas; Oh, Yu Jin; Zhu, Shude; Trepka, Ethan B.; Moore, Tirin
  作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：Persistent, memorandum-specific neuronal spiking activity has long been hypothesized to underlie working memory(1,2). However, emerging evidence suggests a potential role for 'activity-silent' synaptic mechanisms(3-5). This issue remains controversial because evidence for either view has largely relied either on datasets that fail to capture single-trial population dynamics or on indirect measures of neuronal spiking. We addressed this controversy by examining the dynamics of mnemonic informat...
• Large language models can help to translate science into real-world impact AI翻译
  作者：Dhakal, Sandeep; Parry, Hazel
  作者单位：Commonwealth Scientific & Industrial Research Organisation (CSIRO)