2024

最新文章

• Advising governments about science is essential but difficult. So train people to do it AI翻译
  作者：Oliver, K.
• Differentiation fate of a stem-like CD4 T cell controls immunity to cancer AI翻译
  作者：Cardenas, Maria A.; Prokhnevska, Nataliya; Sobierajska, Ewelina; Gregorova, Petra; Medina, Christopher B.; Valanparambil, Rajesh M.; Greenwald, Rachel; DelBalzo, Luke; Bilen, Mehmet Asim; Joshi, Shreyes; Naryan, Vikram; Master, Viraj A.; Sanda, Martin G.; Kissick, Haydn T.
  作者单位：Emory University; Emory University; Emory University; Emory University; Emory University
  摘要：The T cell response to cancer controls disease progression and response to immunotherapy1-3. Despite extensive knowledge regarding CD8 T cells, how CD4 T cells contribute to this process is less well understood. Here we identified a population of PD1+TCF1+ CD4 T cells with stem-like properties that are capable of self-renewal and differentiation into canonical CD4 effector cells. Primarily residing in tumour-draining lymph nodes (TDLNs), these tumour-specific CD4 T cells are restricted by T re...
• Quantum scars make their mark in graphene AI翻译
  作者：Abanin, Dmitry; Serbyn, Maksym
  作者单位：Princeton University; Institute of Science & Technology - Austria
  摘要：By patterning an ultrathin layered structure with tiny wells, physicists have created and imaged peculiar states known as quantum scars - revealing behaviour that could be used to boost the performance of electronic devices.
• Neuronal sequences in population bursts encode information in human cortex AI翻译
  作者：Xie, Weizhen; Wittig Jr, John H.; Chapeton, Julio I.; El-Kalliny, Mostafa; Jackson, Samantha N.; Inati, Sara K.; Zaghloul, Kareem A.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University System of Maryland; University of Maryland College Park
  摘要：Neural coding has traditionally been examined through changes in firing rates and latencies in response to different stimuli1-5. However, populations of neurons can also exhibit transient bursts of spiking activity, wherein neurons fire in a specific temporal order or sequence6-8. The human brain may utilize these neuronal sequences within population bursts to efficiently represent information9-12, thereby complementing the well-known neural code based on spike rate or latency. Here we examine...
• Fat cells have a 'memory' of obesity - hinting at why it's hard to keep weight off AI翻译
  作者：Watson, Traci
• Clonal dynamics after allogeneic haematopoietic cell transplantation AI翻译
  作者：Chapman, Michael Spencer; Wilk, C. Matthias; Boettcher, Steffen; Mitchell, Emily; Dawson, Kevin; Williams, Nicholas; Muller, Jan; Kovtonyuk, Larisa; Jung, Hyunchul; Caiado, Francisco; Roberts, Kirsty; O'Neill, Laura; Kent, David G.; Green, Anthony R.; Nangalia, Jyoti; Manz, Markus G.; Campbell, Peter J.
  作者单位：Wellcome Trust Sanger Institute; University of Cambridge; University of Zurich; University of Zurich; University Zurich Hospital; University of York - UK
  摘要：Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor(1,2). Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes from 2,824 single-cell-derived haematopoietic colonies of ten donor-recipient pairs taken 9-31 years after HLA-matched sibling HCT3. With younger donors (18-47 years at transplant), 5,000-30,000 stem cells had engrafted and were still contributing to haematopoiesis at the t...
• Design of customized coronavirus receptors AI翻译
  作者：Liu, Peng; Huang, Mei-Ling; Guo, Hua; Mccallum, Matthew; Si, Jun-Yu; Chen, Yuan-Mei; Wang, Chun-Li; Yu, Xiao; Shi, Lu-Lu; Xiong, Qing; Ma, Cheng-Bao; Bowen, John E.; Tong, Fei; Liu, Chen; Sun, Ye-hui; Yang, Xiao; Chen, Jing; Guo, Ming; Li, Jing; Corti, Davide; Veesler, David; Shi, Zheng-Li; Yan, Huan
  作者单位：Wuhan University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Guangzhou Laboratory
  摘要：Although coronaviruses use diverse receptors, the characterization of coronaviruses with unknown receptors has been impeded by a lack of infection models1,2. Here we introduce a strategy to engineer functional customized viral receptors (CVRs). The modular design relies on building artificial receptor scaffolds comprising various modules and generating specific virus-binding domains. We identify key factors for CVRs to functionally mimic native receptors by facilitating spike proteolytic cleav...
• Attacks on democracy are attacks on science - and vice versa AI翻译
  作者：Falk, Francesca
  作者单位：University of Bern
• Turning a scientific lens on the wonderful world of fungi AI翻译
  作者：Money, Nicholas P.
  作者单位：University System of Ohio; Miami University
  摘要：A mesmerizing global tour will make readers question what they think they know about mushrooms.
• Growing up slowed down for an early Homo individual AI翻译
  作者：Guatelli-Steinberg, Debbie
  作者单位：University System of Ohio; Ohio State University