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作者：Wang, Ting; Song, Xiaonan; Tan, Jiaxing; Xian, Wei; Zhou, Xingtong; Yu, Mingru; Wang, Xiaofei; Xu, Yan; Wu, Ting; Yuan, Keke; Ran, Yu; Yang, Bing; Fan, Gaofeng; Liu, Xiaoyun; Zhou, Yan; Zhu, Yongqun
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Peking University; ShanghaiTech University; Zhejiang University
摘要：AMPylation is a post-translational modification in which AMP is added to the amino acid side chains of proteins(1,2). Here we show that, with ATP as the ligand and actin as the host activator, the effector protein LnaB of Legionella pneumophila exhibits AMPylase activity towards the phosphoryl group of phosphoribose on PRR42-Ub that is generated by the SidE family of effectors, and deubiquitinases DupA and DupB in an E1- and E2-independent ubiquitination process(3,4,5,6,7). The product of LnaB...
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作者：Brisbois, Marie Claire; Asani, Furaha; Agar, Jon; Rezgui, Yacine; Nedeva, Maria
作者单位：University of Sussex; University of London; University College London; Cardiff University; University of Manchester
摘要：Five scholars share their science-policy priorities for the incoming government as it faces urgent challenges in tackling climate change, health, inequality and more.
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作者：Konagaya, Yumi; Rosenthal, David; Ratnayeke, Nalin; Fan, Yilin; Meyer, Tobias
作者单位：Cornell University; Weill Cornell Medicine; Stanford University; RIKEN; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：Tissue repair, immune defence and cancer progression rely on a vital cellular decision between quiescence and proliferation1,2. Mammalian cells proliferate by triggering a positive feedback mechanism3,4. The transcription factor E2F activates cyclin-dependent kinase 2 (CDK2), which in turn phosphorylates and inactivates the E2F inhibitor protein retinoblastoma (Rb). This action further increases E2F activity to express genes needed for proliferation. Given that positive feedback can inadverten...
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作者：Shermer, Michael
摘要：UFO hunters and anti-vaxxers might seem like modern phenomena, but they both take inspiration from a little-known anti-science movement.
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作者：Gibney, Elizabeth; Wild, Sarah
摘要：Labour Prime Minister Keir Starmer has placed several experts who aren't politicians into government posts.
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作者：[Anonymous]
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作者：[Anonymous]
摘要：The location of an injury determines whether ants bite off or preserve a damaged limb.
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作者：Lesser, Ellen; Azevedo, Anthony W.; Phelps, Jasper S.; Elabbady, Leila; Cook, Andrew; Syed, Durafshan Sakeena; Mark, Brandon; Kuroda, Sumiya; Sustar, Anne; Moussa, Anthony; Dallmann, Chris J.; Agrawal, Sweta; Lee, Su-Yee J.; Pratt, Brandon; Skutt-Kakaria, Kyobi; Gerhard, Stephan; Lu, Ran; Kemnitz, Nico; Lee, Kisuk; Halageri, Akhilesh; Castro, Manuel; Ih, Dodam; Gager, Jay; Tammam, Marwan; Dorkenwald, Sven; Collman, Forrest; Schneider-Mizell, Casey; Brittain, Derrick; Jordan, Chris S.; Macrina, Thomas; Dickinson, Michael; Lee, Wei-Chung Allen; Tuthill, John C.
作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School; University of California System; University of California Santa Barbara; California Institute of Technology; Princeton University; Princeton University; Allen Institute for Brain Science; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles(1). MN activity is coordinated by complex premotor networks that facilitate the contribution of individual muscles to many different behaviours(2-6). Here we use connectomics(7) to analyse the wiring logic of premotor circuits controlling the Drosophila leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related func...
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作者：Hautzinger, Matthew P.; Pan, Xin; Hayden, Steven C.; Ye, Jiselle Y.; Jiang, Qi; Wilson, Mickey J.; Phillips, Alan J.; Dong, Yifan; Raulerson, Emily K.; Leahy, Ian A.; Jiang, Chun-Sheng; Blackburn, Jeffrey L.; Luther, Joseph M.; Lu, Yuan; Jungjohann, Katherine; Vardeny, Z. Valy; Berry, Joseph J.; Alberi, Kirstin; Beard, Matthew C.
作者单位：United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; Utah System of Higher Education; University of Utah; Colorado School of Mines; University of Colorado System; University of Colorado Boulder; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Lorraine; University of Colorado System; University of Colorado Boulder
摘要：Spin accumulation in semiconductor structures at room temperature and without magnetic fields is key to enable a broader range of optoelectronic functionality1. Current efforts are limited owing to inherent inefficiencies associated with spin injection across semiconductor interfaces2. Here we demonstrate spin injection across chiral halide perovskite/III-V interfaces achieving spin accumulation in a standard semiconductor III-V (AlxGa1-x)0.5In0.5P multiple quantum well light-emitting diode. T...
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作者：Bigagli, Niccolo; Yuan, Weijun; Zhang, Siwei; Bulatovic, Boris; Karman, Tijs; Stevenson, Ian; Will, Sebastian
作者单位：Columbia University; Radboud University Nijmegen
摘要：Ensembles of particles governed by quantum mechanical laws exhibit intriguing emergent behaviour. Atomic quantum gases(1,2), liquid helium(3,4) and electrons in quantum materials(5-7) all exhibit distinct properties because of their composition and interactions. Quantum degenerate samples of ultracold dipolar molecules promise the realization of new phases of matter and new avenues for quantum simulation(8) and quantum computation(9). However, rapid losses(10), even when reduced through collis...
