2024

最新文章

• Harrowing trends: how endangered-species researchers find hope in the dark AI翻译
  作者：Forrester, Nikki
  摘要：When data collection can be damaging, conservation scientists must balance ethical trade-offs between interference and inaction.
• How Canada boosted PhD and postdoc pay AI翻译
  作者：Kharas, Kaitlin
  作者单位：University of Toronto
• The economic commitment of climate change (vol 628, pg 551, 2024) AI翻译
  作者：Kotz, Maximilian; Levermann, Anders; Wenz, Leonie
• Ultra-detailed brain map shows neurons that encode words' meaning AI翻译
  作者：Reardon, Sara
  摘要：For the first time, scientists identify individual brain cells linked to the linguistic essence of a word.
• Connectomic reconstruction of a female Drosophila ventral nerve cord AI翻译
  作者：Azevedo, Anthony; Lesser, Ellen; Phelps, Jasper S.; Mark, Brandon; Elabbady, Leila; Kuroda, Sumiya; Sustar, Anne; Moussa, Anthony; Khandelwal, Avinash; Dallmann, Chris J.; Agrawal, Sweta; Lee, Su-Yee J.; Pratt, Brandon; Cook, Andrew; Skutt-Kakaria, Kyobi; Gerhard, Stephan; Lu, Ran; Kemnitz, Nico; Lee, Kisuk; Halageri, Akhilesh; Castro, Manuel; Ih, Dodam; Gager, Jay; Tammam, Marwan; Dorkenwald, Sven; Collman, Forrest; Schneider-Mizell, Casey; Brittain, Derrick; Jordan, Chris S.; Dickinson, Michael; Pacureanu, Alexandra; Seung, H. Sebastian; Macrina, Thomas; Lee, Wei-Chung Allen; Tuthill, John C.
  作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School; California Institute of Technology; Princeton University; Princeton University; Allen Institute for Brain Science; European Synchrotron Radiation Facility (ESRF); Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：A deep understanding of how the brain controls behaviour requires mapping neural circuits down to the muscles that they control. Here, we apply automated tools to segment neurons and identify synapses in an electron microscopy dataset of an adult female Drosophila melanogaster ventral nerve cord (VNC)(1), which functions like the vertebrate spinal cord to sense and control the body. We find that the fly VNC contains roughly 45 million synapses and 14,600 neuronal cell bodies. To interpret the ...
• Disease-associated astrocyte epigenetic memory promotes CNS pathology (vol 627, pg 865, 2024) AI翻译
  作者：Lee, Hong-Gyun; Rone, Joseph M.; Li, Zhaorong; Akl, Camilo Faust; Shin, Seung Won; Lee, Joon-Hyuk; Flausino, Lucas E.; Pernin, Florian; Chao, Chun-Cheih; Kleemann, Kilian L.; Srun, Lena; Illouz, Tomer; Giovannoni, Federico; Charabati, Marc; Sanmarco, Liliana M.; Kenison, Jessica E.; Piester, Gavin; Zandee, Stephanie E. J.; Antel, Jack P.; Rothhammer, Veit; Wheeler, Michael A.; Prat, Alexandre; Clark, Iain C.; Quintana, Francisco J.
• Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587 AI翻译
  作者：Zhang, Yuying; Lai, Yuezheng; Zhou, Shan; Ran, Ting; Zhang, Yue; Zhao, Ziqing; Feng, Ziyan; Yu, Long; Xu, Jinxu; Shi, Kun; Wang, Jianyun; Pang, Yu; Li, Liang; Chen, Hongming; Guddat, Luke W.; Gao, Yan; Liu, Fengjiang; Rao, Zihe; Gong, Hongri
  作者单位：Nankai University; Nankai University; Guangzhou Laboratory; Capital Medical University; University of Queensland; ShanghaiTech University; ShanghaiTech University; Tsinghua University
  摘要：Bedaquiline (BDQ), a first-in-class diarylquinoline anti-tuberculosis drug, and its analogue, TBAJ-587, prevent the growth and proliferation of Mycobacterium tuberculosis by inhibiting ATP synthase1,2. However, BDQ also inhibits human ATP synthase3. At present, how these compounds interact with either M. tuberculosis ATP synthase or human ATP synthase is unclear. Here we present cryogenic electron microscopy structures of M. tuberculosis ATP synthase with and without BDQ and TBAJ-587 bound, an...
• Bitter taste TAS2R14 activation by intracellular tastants and cholesterol AI翻译
  作者：Hu, Xiaolong; Ao, Weizhen; Gao, Mingxin; Wu, Lijie; Pei, Yuan; Liu, Shenhui; Wu, Yiran; Zhao, Fei; Sun, Qianqian; Liu, Junlin; Jiang, Longquan; Wang, Xin; Li, Yan; Tan, Qiwen; Cheng, Jie; Yang, Fan; Yang, Chi; Sun, Jinpeng; Hua, Tian; Liu, Zhi-Jie
  作者单位：ShanghaiTech University; ShanghaiTech University; Shandong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents(1,2). TAS2R14 is also widely expressed in extragustatory tissues, suggesting its extra roles in diverse physiological processes and potential therapeutic applications(3). Here we present cryogenic electron microscopy structures of TAS2R14 in complex with aristolochic acid, flufenamic acid and compound 28.1, coupling with diff...
• No CRISPR: oddball 'jumping gene' enzyme edits genomes without breaking DNA AI翻译
  作者：Ledford, Heidi
• Drosophila immune cells transport oxygen through PPO2 protein phase transition AI翻译
  作者：Shin, Mingyu; Chang, Eunji; Lee, Daewon; Kim, Nayun; Cho, Bumsik; Cha, Nuri; Koranteng, Ferdinand; Song, Ji-Joon; Shim, Jiwon
  作者单位：Hanyang University; Korea Advanced Institute of Science & Technology (KAIST); Hanyang University; Hanyang University; Hanyang University
  摘要：Insect respiration has long been thought to be solely dependent on an elaborate tracheal system without assistance from the circulatory system or immune cells1,2. Here we describe that Drosophila crystal cells-myeloid-like immune cells called haemocytes-control respiration by oxygenating Prophenoloxidase 2 (PPO2) proteins. Crystal cells direct the movement of haemocytes between the trachea of the larval body wall and the circulation to collect oxygen. Aided by copper and a neutral pH, oxygen i...