Synaptic architecture of leg and wing premotor control networks in Drosophila

• 成果类型: Article
• 署名作者: Lesser, Ellen; Azevedo, Anthony W.; Phelps, Jasper S.; Elabbady, Leila; Cook, Andrew; Syed, Durafshan Sakeena; Mark, Brandon; Kuroda, Sumiya; Sustar, Anne; Moussa, Anthony; Dallmann, Chris J.; Agrawal, Sweta; Lee, Su-Yee J.; Pratt, Brandon; Skutt-Kakaria, Kyobi; Gerhard, Stephan; Lu, Ran; Kemnitz, Nico; Lee, Kisuk; Halageri, Akhilesh; Castro, Manuel; Ih, Dodam; Gager, Jay; Tammam, Marwan; Dorkenwald, Sven; Collman, Forrest; Schneider-Mizell, Casey; Brittain, Derrick; Jordan, Chris S.; Macrina, Thomas; Dickinson, Michael; Lee, Wei-Chung Allen; Tuthill, John C.
• 署名单位: University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School; University of California System; University of California Santa Barbara; California Institute of Technology; Princeton University; Princeton University; Allen Institute for Brain Science; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4823
• DOI: 10.1038/s41586-024-07600-z
• 发表日期: 2024-07-11
• 页码: 369-+
• 关键词: motor-neuron; muscle synergies; steering muscle; output; units; pool; reconstruction; ORGANIZATION; motoneurons; specificity

摘要

Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles(1). MN activity is coordinated by complex premotor networks that facilitate the contribution of individual muscles to many different behaviours(2-6). Here we use connectomics(7) to analyse the wiring logic of premotor circuits controlling the Drosophila leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related functions. Within most leg motor modules, the synaptic weights of each premotor neuron are proportional to the size of their target MNs, establishing a circuit basis for hierarchical MN recruitment. By contrast, wing premotor networks lack proportional synaptic connectivity, which may enable more flexible recruitment of wing steering muscles. Through comparison of the architecture of distinct motor control systems within the same animal, we identify common principles of premotor network organization and specializations that reflect the unique biomechanical constraints and evolutionary origins of leg and wing motor control.