-
作者：Coban, Ivo; Lamping, Jan-Philipp; Hirsch, Anna Greta; Wasilewski, Sarah; Shomroni, Orr; Giesbrecht, Oliver; Salinas, Gabriela; Krebber, Heike
作者单位：University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
摘要：When mRNAs have been transcribed and processed in the nucleus, they are exported to the cytoplasm for translation. This export is mediated by the export receptor heterodimer Mex67-Mtr2 in the yeast Saccharomyces cerevisiae (TAP-p15 in humans)(1,2). Interestingly, many long non-coding RNAs (lncRNAs) also leave the nucleus but it is currently unclear why they move to the cytoplasm(3). Here we show that antisense RNAs (asRNAs) accelerate mRNA export by annealing with their sense counterparts thro...
-
作者：Goverde, Casper A.; Pacesa, Martin; Goldbach, Nicolas; Dornfeld, Lars J.; Balbi, Petra E. M.; Georgeon, Sandrine; Rosset, Stephane; Kapoor, Srajan; Choudhury, Jagrity; Dauparas, Justas; Schellhaas, Christian; Kozlov, Simon; Baker, David; Ovchinnikov, Sergey; Vecchio, Alex J.; Correia, Bruno E.
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Massachusetts Institute of Technology (MIT); University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：De novo design of complex protein folds using solely computational means remains a substantial challenge 1 . Here we use a robust deep learning pipeline to design complex folds and soluble analogues of integral membrane proteins. Unique membrane topologies, such as those from G-protein-coupled receptors 2 , are not found in the soluble proteome, and we demonstrate that their structural features can be recapitulated in solution. Biophysical analyses demonstrate the high thermal stability of the...
-
作者：[Anonymous]
-
作者：Chomaz, Lauriane
作者单位：Ruprecht Karls University Heidelberg
摘要：A gas of molecules that interact over long distances has been cooled to mere nanokelvins, resulting in the emergence of a state known as a Bose-Einstein condensate - the first of its kind in this type of molecular system.
-
作者：Wang, Wei; Vidale, John E.; Pang, Guanning; Koper, Keith D.; Wang, Ruoyan
作者单位：Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Southern California; Cornell University; Utah System of Higher Education; University of Utah
摘要：The solid inner core, suspended within the liquid outer core and anchored by gravity, has been inferred to rotate relative to the surface of Earth or change over years to decades based on changes in seismograms from repeating earthquakes and explosions(1,2). It has a rich inner structure(3-6) and influences the pattern of outer core convection and therefore Earth's magnetic field. Here we compile 143 distinct pairs of repeating earthquakes, many within 16 multiplets, built from 121 earthquakes...
-
作者：Li, Chushan; Xu, Fan; Li, Bohao; Li, Jiayi; Li, Guoan; Watanabe, Kenji; Taniguchi, Takashi; Tong, Bingbing; Shen, Jie; Lu, Li; Jia, Jinfeng; Wu, Fengcheng; Liu, Xiaoxue; Li, Tingxin
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Wuhan University; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; National Institute for Materials Science; National Institute for Materials Science; Hefei National Laboratory
摘要：Graphene-based, high-quality, two-dimensional electronic systems have emerged as a highly tunable platform for studying superconductivity(1-21). Specifically, superconductivity has been observed in both electron- and hole-doped twisted graphene moire systems(1-17), whereas in crystalline graphene systems, superconductivity has so far been observed only in hole-doped rhombohedral trilayer graphene (RTG)(18) and hole-doped Bernal bilayer graphene (BBG)(19-21). Recently, enhanced superconductivit...
-
作者：Guo, Zhenxiang
作者单位：Beijing Sport University
-
作者：Haggard, Daryl; Cool, Adrienne
作者单位：McGill University; McGill University; California State University System; San Francisco State University
-
作者：Wang, Meixiang; Xiao, Xun; Siddika, Salma; Shamsi, Mohammad; Frey, Ethan; Qian, Wen; Bai, Wubin; O'Connor, Brendan T.; Dickey, Michael D.
作者单位：North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; North Carolina State University; University of Nebraska System; University of Nebraska Lincoln; North Carolina State University
摘要：Glassy polymers are generally stiff and strong yet have limited extensibility(1). By swelling with solvent, glassy polymers can become gels that are soft and weak yet have enhanced extensibility(1-3). The marked changes in properties arise from the solvent increasing free volume between chains while weakening polymer-polymer interactions. Here we show that solvating polar polymers with ionic liquids (that is, ionogels(4,5)) at appropriate concentrations can produce a unique class of materials ...
-
作者：[Anonymous]
