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作者：Zhang, Mingkai; Chapman, Matthew; Sarode, Bhagyesh R.; Xiong, Bingcong; Liang, Hao; Chen, James K.; Weerapana, Eranthie; Morken, James P.
作者单位：Boston College; Stanford University; Stanford University; Stanford University
摘要：Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug(1). Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs(2). Moreover, whereas aromatic rings are planar and lack three-dimensionality, the binding pockets of most pharmaceutical targets are ...
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作者：Collinson, Glyn A.; Glocer, Alex; Pfaff, Robert; Barjatya, Aroh; Conway, Rachel; Breneman, Aaron; Clemmons, James; Eparvier, Francis; Michell, Robert; Mitchell, David; Imber, Suzie; Akbari, Hassanali; Davis, Lance; Kavanagh, Andrew; Robertson, Ellen; Swanson, Diana; Xu, Shaosui; Miller, Jacob; Cameron, Timothy; Chornay, Dennis; Uribe, Paulo; Nguyen, Long; Clayton, Robert; Graves, Nathan; Debchoudhury, Shantanab; Valentine, Henry; Ghalib, Ahmed
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Catholic University of America; Embry-Riddle Aeronautical University; University System Of New Hampshire; University of New Hampshire; University of Colorado System; University of Colorado Boulder; University of California System; University of California Berkeley; University of Leicester; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Wallops Flight Facility
摘要：Cold plasma of ionospheric origin has recently been found to be a much larger contributor to the magnetosphere of Earth than expected(1-3). Numerous competing mechanisms have been postulated to drive ion escape to space, including heating and acceleration by wave-particle interactions(4) and a global electrostatic field between the ionosphere and space (called the ambipolar or polarization field)(5,6). Observations of heated O+ ions in the magnetosphere are consistent with resonant wave-partic...
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作者：Polonen, Petri; Di Giacomo, Danika; Seffernick, Anna Eames; Elsayed, Abdelrahman; Kimura, Shunsuke; Benini, Francesca; Montefiori, Lindsey E.; Wood, Brent L.; Xu, Jason; Chen, Changya; Cheng, Zhongshan; Newman, Haley; Myers, Jason; Iacobucci, Ilaria; Li, Elizabeth; Sussman, Jonathan; Hedges, Dale; Hui, Yawei; Diorio, Caroline; Uppuluri, Lahari; Frank, David; Fan, Yiping; Chang, Yunchao; Meshinchi, Soheil; Ries, Rhonda; Shraim, Rawan; Li, Alexander; Bernt, Kathrin M.; Devidas, Meenakshi; Winter, Stuart S.; Dunsmore, Kimberly P.; Inaba, Hiroto; Carroll, William L.; Ramirez, Nilsa C.; Phillips, Aaron H.; Kriwacki, Richard W.; Yang, Jun J.; Vincent, Tiffaney L.; Zhao, Yaqi; Ghate, Pankaj S.; Wang, Jian; Reilly, Colleen; Zhou, Xin; Sanders, Mathijs A.; Takita, Junko; Kato, Motohiro; Takasugi, Nao; Chang, Bill H.; Press, Richard D.; Loh, Mignon; Rampersaud, Evadnie; Raetz, Elizabeth; Hunger, Stephen P.; Tan, Kai; Chang, Ti-Cheng; Wu, Gang; Pounds, Stanley B.; Mullighan, Charles G.; Teachey, David T.
作者单位：St Jude Children's Research Hospital; University of Perugia; St Jude Children's Research Hospital; Sapienza University Rome; IRCCS Bambino Gesu; Children's Hospital Los Angeles; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; St Jude Children's Research Hospital; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Fred Hutchinson Cancer Center; St Jude Children's Research Hospital; Children's Hospitals & Clinics of Minnesota; Children's Hospitals & Clinics of Minnesota; University of Virginia; St Jude Children's Research Hospital; NYU Langone Medical Center; NYU Langone Medical Center; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; St Jude Children's Research Hospital; University of Tennessee System; University of Tennessee Health Science Center; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Erasmus University Rotterdam; Erasmus MC; Erasmus MC Cancer Institute; Wellcome Trust Sanger Institute; Kyoto University; University of Tokyo; Oregon Health & Science University; Oregon Health & Science University; Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Seattle Children's Hospital; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
摘要：T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour(1) that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation(2,3). Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell pr...
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作者：Alcon, Pablo; Kaczmarczyk, Artur P.; Ray, Korak Kumar; Liolios, Themistoklis; Guilbaud, Guillaume; Sijacki, Tamara; Shen, Yichao; McLaughlin, Stephen H.; Sale, Julian E.; Knipscheer, Puck; Rueda, David S.; Passmore, Lori A.
作者单位：MRC Laboratory Molecular Biology; Imperial College London; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center
摘要：DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion(1). However, D2-I is also known to have a more general role in DNA repair and in protecting stalled replication forks from unscheduled degradation(2-4). At present, it is unclear how DNA crosslinks are recognized and how D2-I functions in replication fork protection. Here, ...
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作者：Gibney, Elizabeth
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作者：Hoang-Vu Phan; Park, Hoon Cheol; Floreano, Dario
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Konkuk University
摘要：Birds, bats and many insects can tuck their wings against their bodies when at rest and deploy them to power flight. Whereas birds and bats use well-developed pectoral and wing muscles(1,2), how insects control their wing deployment and retraction remains unclear because this varies among insect species. Beetles (Coleoptera) display one of the most complex mechanisms. In rhinoceros beetles, Allomyrina dichotoma, wing deployment is initiated by complete release of the elytra and partial release...
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作者：Wu, Kejia; Zhou, Lei; Tahon, Guillaume; Liu, Laiyan; Li, Jiang; Zhang, Jianchao; Zheng, Fengfeng; Deng, Chengpeng; Han, Wenhao; Bai, Liping; Fu, Lin; Dong, Xiuzhu; Zhang, Chuanlun; Ettema, Thijs J. G.; Sousa, Diana Z.; Cheng, Lei
作者单位：Chinese Academy of Agricultural Sciences; Biogas Institute of Ministry of Agriculture, CAAS; Wageningen University & Research; Tianjin University; Southern University of Science & Technology; Chinese Academy of Sciences; Institute of Microbiology, CAS
摘要：Methanogenic archaea are main contributors to methane emissions, and have a crucial role in carbon cycling and global warming. Until recently, methanogens were confined to Euryarchaeota, but metagenomic studies revealed the presence of genes encoding the methyl coenzyme M reductase complex in other archaeal clades1-4, thereby opening up the premise that methanogenesis is taxonomically more widespread. Nevertheless, laboratory cultivation of these non-euryarchaeal methanogens was lacking to cor...
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作者：Conroy, Gemma
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作者：Eisenstein, Michael
摘要：Results raise hopes that methods could be developed to detect the earliest stages of neurodegenerative disease.
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作者：Erwin, Douglas H.
摘要：Even 'untouched' natural landscapes bear witness to millennia of human influence, a lyrical book argues - with implications for how we seek to rewild them.
