2024

最新文章

• The genomic landscape of 2,023 colorectal cancers AI翻译
  作者：Cornish, Alex J.; Gruber, Andreas J.; Kinnersley, Ben; Chubb, Daniel; Frangou, Anna; Caravagna, Giulio; Noyvert, Boris; Lakatos, Eszter; Wood, Henry M.; Thorn, Steve; Culliford, Richard; Arnedo-Pac, Claudia; Househam, Jacob; Cross, William; Sud, Amit; Law, Philip; Ni Leathlobhair, Maire; Hawari, Aliah; Woolley, Connor; Sherwood, Kitty; Feeley, Nathalie; Guel, Gueler; Fernandez-Tajes, Juan; Zapata, Luis; Alexandrov, Ludmil B.; Murugaesu, Nirupa; Sosinsky, Alona; Mitchell, Jonathan; Lopez-Bigas, Nuria; Quirke, Philip; Church, David N.; Tomlinson, Ian P. M.; Sottoriva, Andrea; Graham, Trevor A.; Wedge, David C.; Houlston, Richard S.
  作者单位：University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of Konstanz; University of Manchester; University of London; University College London; University of Oxford; Max Planck Society; University of Trieste; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of Birmingham; Cancer Research UK; University of Birmingham; Chalmers University of Technology; University of Leeds; University of Oxford; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; ICREA; University of London; University College London; Trinity College Dublin; University of Edinburgh; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of London; Queen Mary University London; University of Oxford; Wellcome Centre for Human Genetics; Oxford University Hospitals NHS Foundation Trust; Human Technopole
  摘要：Colorectal carcinoma (CRC) is a common cause of mortality(1), but a comprehensive description of its genomic landscape is lacking(2-9). Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer. Integrated analyses identify more than 250 putative CRC driver genes, many not previously implicated in CRC or other cancers, including several recurrent changes outsi...
• Montreal Protocol is no 'zombie' deal AI翻译
  作者：Zaelke, Durwood; Bledsoe, Paul
  作者单位：American University
• Remodelling of the translatome controls diet and its impact on tumorigenesis AI翻译
  作者：Yang, Haojun; Zingaro, Vincenzo Andrea; Lincoff, James; Tom, Harrison; Oikawa, Satoshi; Oses-Prieto, Juan A.; Edmondson, Quinn; Seiple, Ian; Shah, Hardik; Kajimura, Shingo; Burlingame, Alma L.; Grabe, Michael; Ruggero, Davide
  作者单位：University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Howard Hughes Medical Institute; Robert H. Lurie Comprehensive Cancer Center; University of Chicago; University of California System; University of California San Francisco
  摘要：Fasting is associated with a range of health benefits(1-6). How fasting signals elicit changes in the proteome to establish metabolic programmes remains poorly understood. Here we show that hepatocytes selectively remodel the translatome while global translation is paradoxically downregulated during fasting(7,8). We discover that phosphorylation of eukaryotic translation initiation factor 4E (P-eIF4E) is induced during fasting. We show that P-eIF4E is responsible for controlling the translatio...
• Why repairing forests is not just about planting trees AI翻译
  作者：Manna, Debraj
  作者单位：Indian Institute of Science (IISC) - Bangalore
  摘要：An exploration of deforestation and restoration shows that woods are much more than trees. They depend on - and provide for - people, animals and microbes.
• Signatures of hybridization of multiple Majorana zero modes in a vortex AI翻译
  作者：Liu, Tengteng; Wan, Chun Yu; Yang, Hao; Zhao, Yujun; Xie, Bangjin; Zheng, Weiyan; Yi, Zhaoxia; Guan, Dandan; Wang, Shiyong; Zheng, Hao; Liu, Canhua; Fu, Liang; Liu, Junwei; Li, Yaoyi; Jia, Jinfeng
  作者单位：Shanghai Jiao Tong University; Hong Kong University of Science & Technology; Hefei National Laboratory; Massachusetts Institute of Technology (MIT); Southern University of Science & Technology
  摘要：Majorana zero modes (MZMs) are emergent zero-energy topological quasiparticles that are their own antiparticles(1,2). Detected MZMs are spatially separated and electrically neutral, so producing hybridization between MZMs is extremely challenging in superconductors(3,4). Here, we report the magnetic field response of vortex bound states in superconducting topological crystalline insulator SnTe (001) films. Several MZMs were predicted to coexist in a single vortex due to magnetic mirror symmetr...
• Multi-habitat landscapes are more diverse and stable with improved function AI翻译
  作者：Hackett, Talya D.; Sauve, Alix M. C.; Maia, Kate P.; Montoya, Daniel; Davies, Nancy; Archer, Rose; Potts, Simon G.; Tylianakis, Jason M.; Vaughan, Ian P.; Memmott, Jane
  作者单位：University of Bristol; University of Oxford; University of Bristol; Universite de Bordeaux; Universidade de Sao Paulo; Basque Centre for Climate Change (BC3); Basque Foundation for Science; University of Reading; University of Canterbury; University of Canterbury; Cardiff University
  摘要：Conservation, restoration and land management are increasingly implemented at landscape scales(1,2). However, because species interaction data are typically habitat- and/or guild-specific, exactly how those interactions connect habitats and affect the stability and function of communities at landscape scales remains poorly understood. We combine multi-guild species interaction data (plant-pollinator and three plant-herbivore-parasitoid communities, collected from landscapes with one, two or th...
• Gravitational instability in a planet-forming disk AI翻译
  作者：Speedie, Jessica; Dong, Ruobing; Hall, Cassandra; Longarini, Cristiano; Veronesi, Benedetta; Paneque-Carreno, Teresa; Lodato, Giuseppe; Tang, Ya-Wen; Teague, Richard; Hashimoto, Jun
  作者单位：University of Victoria; Peking University; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Milan; University of Cambridge; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Ecole Normale Superieure de Lyon (ENS de LYON); Leiden University - Excl LUMC; Leiden University; European Southern Observatory; Academia Sinica - Taiwan; Massachusetts Institute of Technology (MIT); National Institutes of Natural Sciences (NINS) - Japan; Astrobiology Center (ABC); National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); Graduate University for Advanced Studies - Japan
  摘要：The canonical theory for planet formation in circumstellar disks proposes that planets are grown from initially much smaller seeds(1-5). The long-considered alternative theory proposes that giant protoplanets can be formed directly from collapsing fragments of vast spiral arms(6-11) induced by gravitational instability(12-14)-if the disk is gravitationally unstable. For this to be possible, the disk must be massive compared with the central star: a disk-to-star mass ratio of 1:10 is widely hel...
• Whaling convention is the best we've got AI翻译
  作者：Wold, Chris
  作者单位：Lewis & Clark College
• Progress on nuclear clocks shows the benefits of escaping from scientific silos AI翻译
  作者：[Anonymous]
• Chandrayaan-3 APXS elemental abundance measurements at lunar high latitude AI翻译
  作者：Vadawale, Santosh V.; Mithun, N. P. S.; Shanmugam, M.; Basu Sarbadhikari, Amit; Sinha, Rishitosh K.; Bhatt, Megha; Vijayan, S.; Srivastava, Neeraj; Shukla, Anil D.; Murty, S. V. S.; Bhardwaj, Anil; Acharya, Y. B.; Patel, Arpit R.; Adalaja, Hiteshkumar L.; Vaishnava, C. S.; Saiguhan, B. S. Bharath; Singh, Nishant; Kumar, Sushil; Painkra, Deepak Kumar; Srivastava, Yash; Nair, Varsha M.; Ladiya, Tinkal; Goyal, Shiv Kumar; Tiwari, Neeraj K.; Narendranath, Shyama; Pillai, Netra S.; Hait, Arup Kumar; Patinge, Aaditya; Kumar, Abhishek; Satya, Neeraj; Subramanian, Vivek R.; Navle, Sonal G.; Venkatesh, R. G.; Abraham, Lalitha; Suresh, K.; Amitabh
  作者单位：Department of Space (DoS), Government of India; Physical Research Laboratory - India; Department of Space (DoS), Government of India; Indian Space Research Organisation (ISRO); U R Rao Satellite Centre (URSC); Department of Space (DoS), Government of India; Indian Space Research Organisation (ISRO); Space Applications Centre (SAC)
  摘要：The elemental composition of the lunar surface provides insights into mechanisms of the formation and evolution of the Moon(1,2). The chemical composition of lunar regolith have so far been precisely measured using the samples collected by the Apollo, Luna and Chang'e 5 missions, which are from equatorial to mid-latitude regions(3,4); lunar meteorites, whose location of origin on the Moon is unknown(5,6); and the in situ measurement from the Chang'e 3 and Chang'e 4 missions(7-9), which are fro...