2024

最新文章

• Energy storage overcapacity can cause power system instability and blackouts, too AI翻译
  作者：Yang, Bo; Zhao, Zunlian
  作者单位：Changsha University; State Grid Corporation of China
• Ancient fish dined on bats - or died trying AI翻译
  作者：[Anonymous]
  摘要：Fossils hint that bats' wings sometimes lodged in fish's throats, leading the bat-eater to die of hunger.
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness AI翻译
  作者：Stewart, Katherine S.; Abdusselamoglu, Merve Deniz; Tierney, Matthew T.; Gola, Anita; Hur, Yun Ha; Gonzales, Kevin A. U.; Yuan, Shaopeng; Bonny, Alain R.; Yang, Yihao; Infarinato, Nicole R.; Cowley, Christopher J.; Levorse, John M.; Pasolli, Hilda Amalia; Ghosh, Sourav; Rothlin, Carla V.; Fuchs, Elaine
  作者单位：Howard Hughes Medical Institute; Rockefeller University; Rockefeller University; Yale University; Yale University; Pohang University of Science & Technology (POSTECH); Memorial Sloan Kettering Cancer Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University
  摘要：Billions of cells are eliminated daily from our bodies(1-4). Although macrophages and dendritic cells are dedicated to migrating and engulfing dying cells and debris, many epithelial and mesenchymal tissue cells can digest nearby apoptotic corpses(1-4). How these non-motile, non-professional phagocytes sense and eliminate dying cells while maintaining their normal tissue functions is unclear. Here we explore the mechanisms that underlie their multifunctionality by exploiting the cyclical bouts...
• A synthetic alternative to horseshoe crabs AI翻译
  作者：Cernak, Tim
  作者单位：University of Michigan System; University of Michigan
• THE SCIENCE AND ETHICS OF HUMAN EMBRYO MODELS AI翻译
  作者：Mallapaty, Smriti
• Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer AI翻译
  作者：Soula, Mariluz; Unlu, Gokhan; Welch, Rachel; Chudnovskiy, Aleksey; Uygur, Beste; Shah, Vyom; Alwaseem, Hanan; Bunk, Paul; Subramanyam, Vishvak; Yeh, Hsi-Wen; Khan, Artem; Heissel, Soren; Goodarzi, Hani; Victora, Gabriel D.; Beyaz, Semir; Birsoy, Kivanc
  作者单位：Rockefeller University; Rockefeller University; Cold Spring Harbor Laboratory; Rockefeller University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco
  摘要：Cancer cells frequently alter their lipids to grow and adapt to their environment(1-3). Despite the critical functions of lipid metabolism in membrane physiology, signalling and energy production, how specific lipids contribute to tumorigenesis remains incompletely understood. Here, using functional genomics and lipidomic approaches, we identified de novo sphingolipid synthesis as an essential pathway for cancer immune evasion. Synthesis of sphingolipids is surprisingly dispensable for cancer ...
• GREEN PASTURES: CUTTING BEEF'S CARBON HOOFPRINT AI翻译
  作者：[Anonymous]
• Prefrontal and lateral entorhinal neurons co-dependently learn item-outcome rules AI翻译
  作者：Jun, Heechul; Lee, Jason Y.; Bleza, Nicholas R.; Ichii, Ayana; Donohue, Jordan D.; Igarashi, Kei M.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes1-4, but the underlying neural circuit mechanisms of this process remain poorly understood. Here we show that deep layers of the lateral entorhinal cortex (LEC) contain two groups of 'item-outcome neurons': one developing activity for rewarded items during learning, and another for punished items. As mice learned an olfactory item-outcome associatio...
• Structural basis for the activity of the type VII CRISPR-Cas system AI翻译
  作者：Yang, Jie; Li, Xuzichao; He, Qiuqiu; Wang, Xiaoshen; Tang, Jingjing; Wang, Tongyao; Zhang, Yi; Yu, Feiyang; Zhang, Shuqin; Liu, Zhikun; Zhang, Lingling; Liao, Fumeng; Yin, Hang; Zhao, Haiyan; Deng, Zengqin; Zhang, Heng
  作者单位：Tianjin Medical University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Wuhan University; Hubei Jiangxia Laboratory
  摘要：The newly identified type VII CRISPR-Cas candidate system uses a CRISPR RNA-guided ribonucleoprotein complex formed by Cas5 and Cas7 proteins to target RNA1. However, the RNA cleavage is executed by a dedicated Cas14 nuclease, which is distinct from the effector nucleases of the other CRISPR-Cas systems. Here we report seven cryo-electron microscopy structures of the Cas14-bound interference complex at different functional states. Cas14, a tetrameric protein in solution, is recruited to the Ca...
• Update regulator guidance on animal research AI翻译
  作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg