8055期

最新文章

• Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase AI翻译
  作者：Wang, Rong; Chen, Baozhi; Elghobashi-Meinhardt, Nadia; Tie, Jian-Ke; Ayala, Alyssa; Zhou, Ning; Qi, Xiaofeng
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University College Dublin; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Texas System; University of Texas Southwestern Medical Center
  摘要：gamma-Glutamyl carboxylase (GGCX) is the sole identified enzyme that uses vitamin K (VK) as a cofactor in humans. This protein catalyses the oxidation of VK hydroquinone to convert specific glutamate residues to gamma-carboxyglutamate residues in VK-dependent proteins (VDPs), which are involved in various essential biological processes and diseases1, 2-3. However, the working mechanism of GGCX remains unclear. Here we report three cryogenic electron microscopy structures of human GGCX: in the ...
• Bad romance: male octopuses inject deadly venom into their mates AI翻译
  作者：[Anonymous]
• What is stopping a complete switch to clean energy? AI翻译
  作者：Plackett, Benjamin
• Accumulating gene errors drive Huntington's disease AI翻译
  作者：Rajagopal, Veera M.; Gelfman, Sahar
  作者单位：Regeneron
• High temporal variability not trend dominates Mediterranean precipitation AI翻译
  作者：Vicente-Serrano, Sergio M.; Tramblay, Yves; Reig, Fergus; Gonzalez-Hidalgo, Jose C.; Begueria, Santiago; Brunetti, Michele; Kalin, Ksenija Cindric; Patalen, Leonardo; Krzic, Aleksandra; Lionello, Piero; Lima, Miguel M.; Trigo, Ricardo M.; El-Kenawy, Ahmed M.; Eddenjal, Ali; Turkes, Murat; Koutroulis, Aristeidis; Manara, Veronica; Maugeri, Maurizio; Badi, Wafae; Mathbout, Shifa; Bertalanic, Renato; Bocheva, Lilia; Dabanli, Ismail; Dumitrescu, Alexandru; Dubuisson, Brigitte; Sahabi-Abed, Salah; Abdulla, Fayez; Fayad, Abbas; Hodzic, Sabina; Ivanov, Mirjana; Radevski, Ivan; Pena-Angulo, Dhais; Lorenzo-Lacruz, Jorge; Dominguez-Castro, Fernando; Gimeno-Sotelo, Luis; Garcia-Herrera, Ricardo; Franquesa, Magi; Halifa-Marin, Amar; Adell-Michavila, Maria; Noguera, Ivan; Barriopedro, David; Garrido-Perez, Jose M.; Azorin-Molina, Cesar; Andres-Martin, Miguel; Gimeno, Luis; Nieto, Raquel; Llasat, Maria Carmen; Markonis, Yannis; Selmi, Rabeb; Ben Rached, Soumaya; Radovanovic, Slavica; Soubeyroux, Jean-Michel; Ribes, Aurelien; Saidi, Mohamed Elmehdi; Bataineh, Siham; El Khalki, El Mahdi; Robaa, Sayed; Boucetta, Amina; Alsafadi, Karam; Mamassis, Nikos; Mohammed, Safwan; Fernandez-Duque, Beatriz; Cheval, Sorin; Moutia, Sara; Stevkov, Aleksandra; Stevkova, Silvana; Luna, M. Yolanda; Potopova, Vera
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); Universite de Montpellier; Institut de Recherche pour le Developpement (IRD); University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'Atmosfera e del Clima (ISAC-CNR); University of Salento; Universidade de Lisboa; Egyptian Knowledge Bank (EKB); Mansoura University; Bogazici University; Technical University of Crete; University of Milan; European University Cyprus; University of Barcelona; Istanbul Technical University; Meteo France; Jordan University of Science & Technology; University of Saskatchewan; Saints Cyril & Methodius University of Skopje; Universidad de La Rioja; Universidade de Lisboa; Universidade de Lisboa; Universidade de Vigo; Complutense University of Madrid; Complutense University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UCM - Instituto de Geociencias (IGEO); UK Centre for Ecology & Hydrology (UKCEH); Consejo Superior de Investigaciones Cientificas (CSIC); University of Valencia; CSIC-GV-UV - Centro de Investigaciones sobre Desertificacion (CIDE); Universidade de Vigo; Consejo Superior de Investigaciones Cientificas (CSIC); University of Barcelona; Czech University of Life Sciences Prague; Meteo France; Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS); Cadi Ayyad University of Marrakech; Mohammed VI Polytechnic University; Egyptian Knowledge Bank (EKB); Cairo University; Xiamen University; National Technical University of Athens; University of Debrecen; Agencia Estatal de Meteorologia (AEMET); Czech University of Life Sciences Prague; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences
  摘要：State-of-the-art climate models project a substantial decline in precipitation for the Mediterranean region in the future1. Supporting this notion, several studies based on observed precipitation data spanning recent decades have suggested a decrease in Mediterranean precipitation2, 3-4, with some attributing a large fraction of this change to anthropogenic influences3,5. Conversely, certain researchers have underlined that Mediterranean precipitation exhibits considerable spatiotemporal varia...
• Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface AI翻译
  作者：Cao, Qing; Ammerman, Aaron; Saimi, Mierxiati; Lin, Zongtao; Shen, Guomin; Chen, Huaping; Sun, Jie; Chai, Mengqi; Liu, Shixuan; Hsu, Fong-Fu; Krezel, Andrzej M.; Gross, Michael L.; Xu, Jinbin; Garcia, Benjamin A.; Liu, Bin; Li, Weikai
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Minnesota System; Harbin Medical University
  摘要：The gamma-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions, including haemostasis, calcium homeostasis, immune response and endocrine regulation1, 2, 3-4. Modulating gamma-carboxylation levels provides prevalent treatments for haemorrhagic and thromboembolic diseases5. This unique post-translational modification requires vitamin K hydroquinone (KH2) to drive highly demanding reactions6 catalysed by the m...
• Precise modelling of mitochondrial diseases using optimized mitoBEs AI翻译
  作者：Zhang, Xiaoxue; Zhang, Xue; Ren, Jiwu; Li, Jiayi; Wei, Xiaoxu; Yu, Ying; Yi, Zongyi; Wei, Wensheng
  作者单位：Changping Laboratory; Peking University; Peking University
  摘要：The development of animal models is crucial for studying and treating mitochondrial diseases. Here we optimized adenine and cytosine deaminases to reduce off-target effects on the transcriptome and the mitochondrial genome, improving the accuracy and efficiency of our newly developed mitochondrial base editors (mitoBEs)1. Using these upgraded mitoBEs (version 2 (v2)), we targeted 70 mouse mitochondrial DNA mutations analogous to human pathogenic variants2, establishing a foundation for mitocho...
• Homogeneous ZnSeTeS quantum dots for efficient and stable pure-blue LEDs AI翻译
  作者：Wu, Qianqian; Cao, Fan; Yu, Wenke; Wang, Sheng; Hou, Wenjun; Lu, Zizhe; Cao, Weiran; Zhang, Jiaqi; Zhang, Xiaoyu; Yang, Yingguo; Jia, Guohua; Zhang, Jianhua; Yang, Xuyong
  作者单位：Shanghai University; Jilin University; Zhangjiang Laboratory; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Fudan University; Curtin University
  摘要：The electroluminescence performance of heavy-metal-free blue quantum dot (QD) light-emitting diodes (QLEDs) is much lower than that of state-of-the-art cadmium-based counterparts. Ecofriendly ZnSeTe QDs are an ideal alternative to cadmium-based blue QDs1,2, but face issues with colour impurity and inferior stability caused by the aggregated tellurium (Ten >= 2) that dominates compositional inhomogeneity3,4. Here we developed an isoelectronic control strategy using congeneric sulfur coordinated...
• Global sea-level rise in the early Holocene revealed from North Sea peats AI翻译
  作者：Hijma, Marc P.; Bradley, Sarah L.; Cohen, Kim M.; van der Wal, Wouter; Barlow, Natasha L. M.; Blank, Bas; Frechen, Manfred; Hennekam, Rick; van Heteren, Sytze; Kiden, Patrick; Mavritsakis, Antonis; Meijninger, Bart M. L.; Reichart, Gert-Jan; Reinhardt, Lutz; Rijsdijk, Kenneth F.; Vink, Annemiek; Busschers, Freek S.
  作者单位：Deltares; Wageningen University & Research; University of Sheffield; Utrecht University; Delft University of Technology; University of Leeds; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Netherlands Organization Applied Science Research; Deltares; Utrecht University; University of Amsterdam
  摘要：Rates of relative sea-level rise during the final stage of the last deglaciation, the early Holocene, are key to understanding future ice melt and sea-level change under a warming climate1. Data about these rates are scarce2, and this limits insight into the relative contributions of the North American and Antarctic ice sheets to global sea-level rise during the early Holocene. Here we present an early Holocene sea-level curve based on 88 sea-level data points (13.7-6.2 thousand years ago (ka)...
• CARD domains mediate anti-phage defence in bacterial gasdermin systems AI翻译
  作者：Wein, Tanita; Millman, Adi; Lange, Katharina; Yirmiya, Erez; Hadary, Romi; Garb, Jeremy; Melamed, Sarah; Amitai, Gil; Dym, Orly; Steinruecke, Felix; Hill, Aidan B.; Kranzusch, Philip J.; Sorek, Rotem
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome activity and pyroptosis1. Following pathogen recognition by nucleotide binding-domain, leucine-rich, repeat-containing (NLR) proteins, CARDs recruit and activate caspases, which, in turn, activate gasdermin pore-forming proteins to induce pyroptotic cell death2. Here we show that CARD domains are present in defence systems that protect bacteria against phage. The bacterial CARD domain is essential ...