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作者：Peinado, Paola; Stazi, Marco; Ballabio, Claudio; Margineanu, Michael-Bogdan; Li, Zhaoqi; Colon, Caterina I.; Hsieh, Min-Shu; Pal Choudhuri, Shreoshi; Stastny, Victor; Hamilton, Seth; Le Marois, Alix; Collingridge, Jodie; Conrad, Linus; Chen, Yinxing; Ng, Sheng Rong; Magendantz, Margaret; Bhutkar, Arjun; Chen, Jin-Shing; Sahai, Erik; Drapkin, Benjamin J.; Jacks, Tyler; Vander Heiden, Matthew G.; Kopanitsa, Maksym V.; Robinson, Hugh P. C.; Li, Leanne
作者单位：Francis Crick Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); National Taiwan University; National Taiwan University Hospital; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Francis Crick Institute; University of Cambridge; National Taiwan University; National Taiwan University Hospital; National Taiwan University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Elevated or ectopic expression of neuronal receptors promotes tumour progression in many cancer types1,2; neuroendocrine (NE) transformation of adenocarcinomas has also been associated with increased aggressiveness3. Whether the defining neuronal feature, namely electrical excitability, exists in cancer cells and impacts cancer progression remains mostly unexplored. Small-cell lung cancer (SCLC) is an archetypal example of a highly aggressive NE cancer and comprises two major distinct subpopul...
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作者：Palsson, Gunnar; Hardarson, Marteinn T.; Jonsson, Hakon; Steinthorsdottir, Valgerdur; Stefansson, Olafur A.; Eggertsson, Hannes P.; Gudjonsson, Sigurjon A.; Olason, Pall I.; Gylfason, Arnaldur; Masson, Gisli; Thorsteinsdottir, Unnur; Sulem, Patrick; Helgason, Agnar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Stefansson, Kari
作者单位：Decode Genetics; Reykjavik University; University of Iceland; University of Iceland; University of Iceland
摘要：Human recombination maps are a valuable resource for association and linkage studies and crucial for many inferences of population history and natural selection. Existing maps1, 2, 3, 4-5 are based solely on cross-over (CO) recombination, omitting non-cross-overs (NCOs)-the more common form of recombination6-owing to the difficulty in detecting them. Using whole-genome sequence data in families, we estimate the number of NCOs transmitted from parent to offspring and derive complete, sex-specif...
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作者：Jones, Julia P. G.
作者单位：Bangor University
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作者：Fang, Xin; Yu, Dianlong; Wen, Jihong; Dai, Yifan; Begley, Matthew R.; Gao, Huajian; Gumbsch, Peter
作者单位：National University of Defense Technology - China; University of California System; University of California Santa Barbara; Tsinghua University; Helmholtz Association; Karlsruhe Institute of Technology; Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Mechanics of Materials
摘要：Mechanical metamaterials with high recoverable elastic energy density, which we refer to as high-enthalpy elastic metamaterials, can offer many enhanced properties, including efficient mechanical energy storage1,2, load-bearing capability, impact resistance and motion agility. These qualities make them ideal for lightweight, miniaturized and multi-functional structures3, 4, 5, 6, 7-8. However, achieving high enthalpy is challenging, as it requires combining conflicting properties: high stiffne...
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Diaz, Francisco Mendez; Corbett, Kevin D.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
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作者：Liu, Ruiqi; Plikus, Maksim V.
作者单位：University of California System; University of California Irvine
摘要：Gills and mammalian ears bear little resemblance, yet examination of gene regulation reveals that key supportive cartilage tissue arises from similar embryonic cells guided by an evolutionarily conserved genetic program.
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作者：Allan, Oscar
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作者：Witze, Alexandra
