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作者：Tong, Kai; Datta, Sayantan; Cheng, Vivian; Haas, Daniella J.; Gourisetti, Saranya; Yopp, Harley L.; Day, Thomas C.; Lac, Dung T.; Khalil, Ahmad S.; Conlin, Peter L.; Bozdag, G. Ozan; Ratcliff, William C.
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Boston University; Boston University; University of Illinois System; University of Illinois Urbana-Champaign; Mayo Clinic; University System of Georgia; Georgia Institute of Technology; University of Southern California; Harvard University
摘要：Whole-genome duplication (WGD) is widespread across eukaryotes and can promote adaptive evolution1, 2, 3-4. However, given the instability of newly formed polyploid genomes5, 6-7, understanding how WGDs arise in a population, persist, and underpin adaptations remains a challenge. Here, using our ongoing Multicellularity Long Term Evolution Experiment (MuLTEE)8, we show that diploid snowflake yeast (Saccharomyces cerevisiae) under selection for larger multicellular size rapidly evolve to be tet...
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作者：Breart, Beatrice; Williams, Katherine; Krimm, Stellanie; Wong, Tiffany; Kayser, Brandon D.; Wang, Lifen; Cheng, Eric; Tleugabulova, Mayra Cruz; Bouziat, Romain; Lu, Tianshi; Yuen, Kobe; Firmino, Natalie S.; Bravo, Daniel D.; Roels, Juliette; Bhakta, Atish; Bevers, Jack; Lehoux, Isabelle; Gutierrez, Alan; Chestnut, Yajun; Klementowicz, Joanna E.; Arenzana, Teresita L.; Akhmetzyanova, Ilseyar; Dixon, Elizabeth; Chen, Min; Tasneem, Kazi; Yadav, Rajbharan; Koeppen, Hartmut; Oh, Soyoung A.; Delamarre, Lelia; Huang, Haochu; Lim, Shion A.; Nakamura, Gerald; Wang, Jianyong; Gao, Chan; Corpuz, Racquel; Mueller, Soeren; West, Nathaniel R.
作者单位：Roche Holding; Roche Holding USA; Genentech
摘要：Although cytotoxic CD8+ T lymphocytes (CTLs) are essential for anti-tumour immunity, they are frequently dysfunctional in tumours1. Cytokines that sustain CTL activity are attractive for cancer immunotherapy, but avoiding inflammatory toxicity remains a challenge for their clinical use2. Here we show that expression of a CTL signature is strongly associated with IL27 expression in human and mouse tumours. In mice, IL-27 acts directly on tumour-specific CTLs to promote their persistence and eff...
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作者：Basilio, Humberto
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作者：Hedley, Esme; Bernal, Alba Graciela Avila
作者单位：Universidad de los Andes (Colombia)
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作者：Zheng, Zhi; Zheng, Lyuqin; Arter, Meret; Liu, Kaixian; Yamada, Shintaro; Ontoso, David; Kim, Soonjoung; Keeney, Scott
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Kyoto University; Kyoto University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute; Yonsei University; Yonsei University Health System
摘要：Meiotic recombination starts with SPO11 generation of DNA double-strand breaks (DSBs)1. SPO11 is critical for meiosis in most species, but it generates dangerous DSBs with mutagenic2 and gametocidal3 potential. Cells must therefore utilize the beneficial functions of SPO11 while minimizing its risks4-how they do so remains poorly understood. Here we report reconstitution of DNA cleavage in vitro with purified recombinant mouse SPO11 bound to TOP6BL. SPO11-TOP6BL complexes are monomeric (1:1) i...
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作者：Zeni, Claudio; Pinsler, Robert; Zuegner, Daniel; Fowler, Andrew; Horton, Matthew; Fu, Xiang; Wang, Zilong; Shysheya, Aliaksandra; Crabbe, Jonathan; Ueda, Shoko; Sordillo, Roberto; Sun, Lixin; Smith, Jake; Nguyen, Bichlien; Schulz, Hannes; Lewis, Sarah; Huang, Chin-Wei; Lu, Ziheng; Zhou, Yichi; Yang, Han; Hao, Hongxia; Li, Jielan; Yang, Chunlei; Li, Wenjie; Tomioka, Ryota; Xie, Tian
作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
摘要：The design of functional materials with desired properties is essential in driving technological advances in areas such as energy storage, catalysis and carbon capture1, 2-3. Generative models accelerate materials design by directly generating new materials given desired property constraints, but current methods have a low success rate in proposing stable crystals or can satisfy only a limited set of property constraints4, 5, 6, 7, 8, 9, 10-11. Here we present MatterGen, a model that generates...
