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作者：Sun, Hequan; Tusso, Sergio; Dent, Craig I.; Goel, Manish; Wijfjes, Raul Y.; Baus, Lisa C.; Dong, Xiao; Campoy, Jose A.; Kurdadze, Ana; Walkemeier, Birgit; Saenger, Christine; Huettel, Bruno; Hutten, Ronald C. B.; van Eck, Herman J.; Dehmer, Klaus J.; Schneeberger, Korbinian
作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; University of Munich; Max Planck Society; Heinrich Heine University Dusseldorf; Max Planck Society; Wageningen University & Research; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Universidad Politecnica de Cartagena
摘要：Potatoes were first brought to Europe in the sixteenth century1,2. Two hundred years later, one of the species had become one of the most important food sources across the entire continent and, later, even the entire world3. However, its highly heterozygous, autotetraploid genome has complicated its improvement since then4, 5, 6-7. Here we present the pan-genome of European potatoes generated from phased genome assemblies of ten historical potato cultivars, which includes approximately 85% of ...
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作者：Li, Luoqi; Long, Di; Wang, Yiming; Woolway, R. Iestyn
作者单位：Tsinghua University; Tsinghua University; Bangor University
摘要：Lakes are crucial for ecosystems1, greenhouse gas emissions2 and water resources3, yet their surface-extent dynamics, particularly seasonality, remain poorly understood at continental to global scales owing to limitations in satellite observations4,5. Although previous studies have focused on long-term changes6, 7-8, comprehensive assessments of seasonality have been constrained by trade-offs between spatial resolution and temporal resolution in single-source satellite data. Here we show that ...
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作者：Klebl, David P.; McMillan, Sean N.; Risi, Cristina; Forgacs, Eva; Virok, Betty; Atherton, Jennifer L.; Harris, Sarah A.; Stofella, Michele; Winkelmann, Donald A.; Sobott, Frank; Galkin, Vitold E.; Knight, Peter J.; Muench, Stephen P.; Scarff, Charlotte A.; White, Howard D.
作者单位：University of Leeds; University of Leeds; University of Leeds; University of Leeds; Old Dominion University; University of Sheffield; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Max Planck Society
摘要：Myosins produce force and movement in cells through interactions with F-actin1. Generation of movement is thought to arise through actin-catalysed conversion of myosin from an ATP-generated primed (pre-powerstroke) state to a post-powerstroke state, accompanied by myosin lever swing2,3. However, the initial, primed actomyosin state has never been observed, and the mechanism by which actin catalyses myosin ATPase activity is unclear. Here, to address these issues, we performed time-resolved cry...
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作者：Tu, Tao; Schaekermann, Mike; Palepu, Anil; Saab, Khaled; Freyberg, Jan; Tanno, Ryutaro; Wang, Amy; Li, Brenna; Amin, Mohamed; Cheng, Yong; Vedadi, Elahe; Tomasev, Nenad; Azizi, Shekoofeh; Singhal, Karan; Hou, Le; Webson, Albert; Kulkarni, Kavita; Mahdavi, S. Sara; Semturs, Christopher; Gottweis, Juraj; Barral, Joelle; Chou, Katherine; Corrado, Greg S.; Matias, Yossi; Karthikesalingam, Alan; Natarajan, Vivek
作者单位：Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind
摘要：At the heart of medicine lies physician-patient dialogue, where skillful history-taking enables effective diagnosis, management and enduring trust1,2. Artificial intelligence (AI) systems capable of diagnostic dialogue could increase accessibility and quality of care. However, approximating clinicians' expertise is an outstanding challenge. Here we introduce AMIE (Articulate Medical Intelligence Explorer), a large language model (LLM)-based AI system optimized for diagnostic dialogue. AMIE use...
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作者：[Anonymous]
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作者：Hosseini, Mohsen; Voisin, Veronique; Chegini, Ali; Varesi, Angelica; Cathelin, Severine; Ayyathan, Dhanoop Manikoth; Liu, Alex C. H.; Yang, Yitong; Wang, Vivian; Maher, Abdula; Grignano, Eric; Reisz, Julie A.; D'Alessandro, Angelo; Young, Kira; Wu, Yiyan; Fiumara, Martina; Ferrari, Samuele; Naldini, Luigi; Gaiti, Federico; Pai, Shraddha; Egan, Grace; Schimmer, Aaron D.; Bader, Gary D.; Dick, John E.; Xie, Stephanie Z.; Trowbridge, Jennifer J.; Chan, Steven M.
作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University of Toronto; University of Toronto; University of Colorado System; University of Colorado Anschutz Medical Campus; Jackson Laboratory; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); Vita-Salute San Raffaele University; University of Toronto; Ontario Institute for Cancer Research; University of Toronto; Hospital for Sick Children (SickKids)
摘要：Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1, 2, 3-4. Suppressing the expansion of mutant HSCs may prevent these outcomes; however, such interventions have not yet been identified. The most common clonal haematopoiesis ...
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作者：Rosenberger, Florian A.; Maedler, Sophia C.; Thorhauge, Katrine Holtz; Steigerwald, Sophia; Fromme, Malin; Lebedev, Mikhail; Weiss, Caroline A. M.; Oeller, Marc; Wahle, Maria; Metousis, Andreas; Zwiebel, Maximilian; Schmacke, Niklas A.; Detlefsen, Soenke; Boor, Peter; Fabian, Ondrej; Frankova, Sona; Krag, Aleksander; Strnad, Pavel; Mann, Matthias
作者单位：Max Planck Society; University of Southern Denmark; RWTH Aachen University; RWTH Aachen University Hospital; University of Munich; University of Munich; University of Southern Denmark; Odense University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; Institute for Clinical & Experimental Medicine (IKEM); Charles University Prague; Thomayer Hospital; Institute for Clinical & Experimental Medicine (IKEM); University of Southern Denmark; Aarhus University; University of Copenhagen
摘要：Protein misfolding diseases, including alpha 1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood1, 2-3. We use spatial proteomics by mass spectrometry and machine learning to map AATD in human liver tissue. Combining Deep Visual Proteomics (DVP) with single-cell analysis4,5, we probe intact patient biopsies to resolve molecular events during hepatocyte stress in pseudotime across fibrosis stages. We achieve proteome depth...
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作者：Cochran, T. A.; Jobst, B.; Rosenberg, E.; Lensky, Y. D.; Gyawali, G.; Eassa, N.; Will, M.; Szasz, A.; Abanin, D.; Acharya, R.; Aghababaie Beni, L.; Andersen, T. I.; Ansmann, M.; Arute, F.; Arya, K.; Asfaw, A.; Atalaya, J.; Babbush, R.; Ballard, B.; Bardin, J. C.; Bengtsson, A.; Bilmes, A.; Bourassa, A.; Bovaird, J.; Broughton, M.; Browne, D. A.; Buchea, B.; Buckley, B. B.; Burger, T.; Burkett, B.; Bushnell, N.; Cabrera, A.; Campero, J.; Chang, H. -S.; Chen, Z.; Chiaro, B.; Claes, J.; Cleland, A. Y.; Cogan, J.; Collins, R.; Conner, P.; Courtney, W.; Crook, A. L.; Curtin, B.; Das, S.; Demura, S.; De Lorenzo, L.; Di Paolo, A.; Donohoe, P.; Drozdov, I.; Dunsworth, A.; Eickbusch, A.; Elbag, A. Moshe; Elzouka, M.; Erickson, C.; Ferreira, V. S.; Burgos, L. Flores; Forati, E.; Fowler, A. G.; Foxen, B.; Ganjam, S.; Gasca, R.; Genois, E.; Giang, W.; Gilboa, D.; Gosula, R.; Grajales Dau, A.; Graumann, D.; Greene, A.; Gross, J. A.; Habegger, S.; Hansen, M.; Harrigan, M. P.; Harrington, S. D.; Heu, P.; Higgott, O.; Hilton, J.; Huang, H. -Y.; Huff, A.; Huggins, W.; Jeffrey, E.; Jiang, Z.; Jones, C.; Joshi, C.; Juhas, P.; Kafri, D.; Kang, H.; Karamlou, A. H.; Kechedzhi, K.; Khaire, T.; Khattar, T.; Khezri, M.; Kim, S.; Klimov, P.; Kobrin, B.; Korotkov, A.; Kostritsa, F.; Kreikebaum, J.; Kurilovich, V.; Landhuis, D.; Lange-Dei, T.; Langley, B.; Lau, K. -M.; Ledford, J.; Lee, K.; Lester, B.; Le Guevel, L.; Li, W.; Lill, A. T.; Livingston, W.; Locharla, A.; Lundahl, D.; Lunt, A.; Madhuk, S.; Maloney, A.; Mandra, S.; Martin, L.; Martin, O.; Maxfield, C.; Mcclean, J.; Mcewen, M.; Meeks, S.; Megrant, A.; Miao, K.; Molavi, R.; Molina, S.; Montazeri, S.; Movassagh, R.; Neill, C.; Newman, M.; Nguyen, A.; Nguyen, M.; Ni, C. -H.; Ottosson, K.; Pizzuto, A.; Potter, R.; Pritchard, O.; Quintana, C.; Ramachandran, G.; Reagor, M.; Rhodes, D.; Roberts, G.; Sankaragomathi, K.; Satzinger, K.; Schurkus, H.; Shearn, M.; Shorter, A.; Shutty, N.; Shvarts, V.; Sivak, V.; Small, S.; Smith, W. C.; Springer, S.; Sterling, G.; Suchard, J.; Sztein, A.; Thor, D.; Torunbalci, M.; Vaishnav, A.; Vargas, J.; Vdovichev, S.; Vidal, G.; Vollgraff Heidweiller, C.; Waltman, S.; Wang, S. X.; Ware, B.; White, T.; Wong, K.; Woo, B. W. K.; Xing, C.; Yao, Z. Jamie; Yeh, P.; Ying, B.; Yoo, J.; Yosri, N.; Young, G.; Zalcman, A.; Zhang, Y.; Zhu, N.; Zobrist, N.; Boixo, S.; Kelly, J.; Lucero, E.; Chen, Y.; Smelyanskiy, V.; Neven, H.; Gammon-Smith, A.; Pollmann, F.; Knap, M.; Roushan, P.
作者单位：Alphabet Inc.; Google Incorporated; Princeton University; Technical University of Munich; Cornell University; Cornell University; Purdue University System; Purdue University; University of Massachusetts System; University of Massachusetts Amherst; University of Connecticut; University of California System; University of California Riverside; University of Nottingham; University of Nottingham
摘要：Lattice gauge theories (LGTs)1, 2, 3-4 can be used to understand a wide range of phenomena, from elementary particle scattering in high-energy physics to effective descriptions of many-body interactions in materials5, 6-7. Studying dynamical properties of emergent phases can be challenging, as it requires solving many-body problems that are generally beyond perturbative limits8, 9-10. Here we investigate the dynamics of local excitations in a Z2\documentclass[12pt]{minimal} \usepackage{amsmath...
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作者：[Anonymous]
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作者：Dolgin, Elie
摘要：Options are emerging for the tens of millions of people who stop taking GLP-1 drugs because of side effects, cost or availability.
