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作者：[Anonymous]
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作者：Hracs, Lindsay; Windsor, Joseph W.; Gorospe, Julia; Cummings, Michael; Coward, Stephanie; Buie, Michael J.; Quan, Joshua; Goddard, Quinn; Caplan, Lea; Markovinovic, Ante; Williamson, Tyler; Abbey, Yvonne; Abdullah, Murdani; Abreu, Maria T.; Ahuja, Vineet; Raja Ali, Raja Affendi; Altuwaijri, Mansour; Balderramo, Domingo; Banerjee, Rupa; Benchimol, Eric I.; Bernstein, Charles N.; Brunet-Mas, Eduard; Burisch, Johan; Chong, Vui Heng; Dotan, Iris; Dutta, Usha; El Ouali, Sara; Forbes, Angela; Forss, Anders; Gearry, Richard; Dao, Viet Hang; Hartono, Juanda Leo; Hilmi, Ida; Hodges, Phoebe; Jones, Gareth-Rhys; Juliao-Banos, Fabian; Kaibullayeva, Jamilya; Kelly, Paul; Kobayashi, Taku; Kotze, Paulo Gustavo; Lakatos, Peter L.; Lees, Charlie W.; Limsrivilai, Julajak; Lo, Bobby; Loftus, Edward V.; Ludvigsson, Jonas F.; Mak, Joyce W. Y.; Miao, Yinglei; Ng, Ka Kei; Okabayashi, Shinji; Olen, Ola; Panaccione, Remo; Paudel, Mukesh Sharma; Quaresma, Abel Botelho; Rubin, David T.; Simadibrata, Marcellus; Sun, Yang; Suzuki, Hidekazu; Toro, Martin; Turner, Dan; Iade, Beatriz; Wei, Shu Chen; Yamamoto-Furusho, Jesus K.; Yang, Suk-Kyun; Ng, Siew C.; Kaplan, Gilaad G.
作者单位：University of Calgary; University of Calgary; University of Indonesia; Dr. Cipto Mangunkusumo National Public Hospital; Cedars Sinai Medical Center; Stockholm School of Economics; All India Institute of Medical Sciences (AIIMS) New Delhi; Sunway University; King Saud University; Hospital Privado - Universitario de Cordoba; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Manitoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Instituto de Salud Carlos III; Autonomous University of Barcelona; University of Copenhagen; Tel Aviv University; Sackler Faculty of Medicine; Rabin Medical Center; Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh; Cleveland Clinic Foundation; Cleveland Clinic Foundation; University of Otago; Karolinska Institutet; Hanoi Medical University; National University of Singapore; National University of Singapore; Universiti Malaya; University of London; Queen Mary University London; University of Zambia; University of Edinburgh; Asfendiyarov Kazakh National Medical University; Kitasato University; Kitasato University; McGill University; Semmelweis University; University of Edinburgh; Mahidol University; Mayo Clinic; Orebro University; Chinese University of Hong Kong; Kyoto University; Karolinska Institutet; Universidade do Oeste de Santa Catarina; University of Chicago; Tokai University; Hebrew University of Jerusalem; Shaare Zedek Medical Center; National Taiwan University; National Taiwan University Hospital; University of Ulsan; Asan Medical Center; Chinese University of Hong Kong; Chinese University of Hong Kong
摘要：During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily2, 3-4. Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage...
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作者：Callaway, Ewen
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作者：Ney, Alyssa
作者单位：University of Munich; University of Munich
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作者：Hong, Jiani; Tian, Ye; Liang, Tiancheng; Liu, Xinmeng; Song, Yizhi; Guan, Dong; Yan, Zixiang; Guo, Jiadong; Tang, Binze; Cao, Duanyun; Guo, Jing; Chen, Ji; Pan, Ding; Xu, Li-Mei; Wang, En-Ge; Jiang, Ying
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作者：Hashiguchi, Akiko
作者单位：University of Tsukuba
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作者：Kraus, D.; Rips, J.; Schoerner, M.; Stevenson, M. G.; Vorberger, J.; Ranjan, D.; Luetgert, J.; Heuser, B.; Eggert, J. H.; Liermann, H. -p.; Oleynik, I. I.; Pandolfi, S.; Redmer, R.; Sollier, A.; Strohm, C.; Volz, T. J.; Albertazzi, B.; Ali, S. J.; Antonelli, L.; Baehtz, C.; Ball, O. B.; Banerjee, S.; Belonoshko, A. B.; Bolme, C. A.; Bouffetier, V.; Briggs, R.; Buakor, K.; Butcher, T.; Cerantola, V.; Chantel, J.; Coleman, A. L.; Collier, J.; Collins, G. W.; Comley, A. J.; Cowan, T. E.; Cristoforetti, G.; Cynn, H.; Descamps, A.; Di Cicco, A.; Di Dio Cafiso, S.; Dorchies, F.; Duff, M. J.; Dwivedi, A.; Edwards, C.; Errandonea, D.; Galitskiy, S.; Galtier, E.; Ginestet, H.; Gizzi, L.; Gleason, A.; Goede, S.; Gonzalez, J. M.; Gorman, M. G.; Harmand, M.; Hartley, N. J.; Heighway, P. G.; Hernandez-Gomez, C.; Higginbotham, A.; Hoeppner, H.; Husband, R. J.; Hutchinson, T. M.; Hwang, H.; Keen, D. A.; Kim, J.; Koester, P.; Konopkova, Z.; Krygier, A.; Labate, L.; Laso Garcia, A.; Lazicki, A. E.; Lee, Y.; Mason, P.; Masruri, M.; Massani, B.; McBride, E. E.; McHardy, J. D.; McGonegle, D.; McGuire, C.; Mcwilliams, R. S.; Merkel, S.; Morard, G.; Nagler, B.; Nakatsutsumi, M.; Nguyen-Cong, K.; Norton, A. -m.; Ozaki, N.; Otzen, C.; Peake, D. J.; Pelka, A.; Pereira, K. A.; Phillips, J. P.; Prescher, C.; Preston, T. R.; Randolph, L.; Ravasio, A.; Santamaria-Perez, D.; Savage, D. J.; Schoelmerich, M.; Schwinkendorf, J. -p.; Singh, S.; Smith, J.; Smith, R. F.; Spear, J.; Spindloe, C.; Suer, T. -a.; Tang, M.; Toncian, M.; Toncian, T.; Tracy, S. J.; Trapananti, A.; Vennari, C. E.; Vinci, T.; Tyldesley, M.; Vogel, S. C.; Walsh, J. P. S.; Wark, J. S.; Willman, J. T.; Wollenweber, L.; Zastrau, U.; Brambrink, E.; Appel, K.; McMahon, M. I.
作者单位：University of Rostock; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); State University System of Florida; University of South Florida; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; Museum National d'Histoire Naturelle (MNHN); Universite Paris Saclay; CEA; Institut Polytechnique de Paris; Ecole Polytechnique; CEA; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of York - UK; University of Edinburgh; University of Edinburgh; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Nanjing University; United States Department of Energy (DOE); Los Alamos National Laboratory; European XFEL; University of Milano-Bicocca; Universite de Lille; Centrale Lille; INRAE; Centre National de la Recherche Scientifique (CNRS); University of Rochester; University of Rochester; University of Rochester; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); Queens University Belfast; University of Camerino; Universite de Bordeaux; CEA; Centre National de la Recherche Scientifique (CNRS); University of Valencia; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); heSam Universite; Conservatoire National Arts & Metiers (CNAM); University of Oxford; Gwangju Institute of Science & Technology (GIST); UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Hanyang University; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); Yonsei University; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Universite Savoie Mont Blanc; University of Osaka; University of Freiburg; University of Massachusetts System; University of Massachusetts Amherst; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Carnegie Institution for Science
摘要：Carbon has a central role in biology and organic chemistry, and its solid allotropes provide the basis of much of our modern technology1. However, the liquid form of carbon remains nearly uncharted2, and the structure of liquid carbon and most of its physical properties are essentially unknown3. But liquid carbon is relevant for modelling planetary interiors4,5 and the atmospheres of white dwarfs6, as an intermediate state for the synthesis of advanced carbon materials7,8, inertial confinement...
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作者：Tavakoli, Mojtaba R.; Lyudchik, Julia; Januszewski, Michal; Vistunou, Vitali; Duenas, Nathalie Agudelo; Vorlaufer, Jakob; Sommer, Christoph; Kreuzinger, Caroline; Oliveira, Barbara; Cenameri, Alban; Novarino, Gaia; Jain, Viren; Danzl, Johann G.
作者单位：Institute of Science & Technology - Austria; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated
摘要：The information-processing capability of the brain's cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of ...
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作者：Gozdecka, Malgorzata; Dudek, Monika; Wen, Sean; Gu, Muxin; Stopforth, Richard J.; Rak, Justyna; Damaskou, Aristi; Grice, Guinevere L.; McLoughlin, Matthew A.; Bond, Laura; Wilson, Rachael; Giotopoulos, George; Shanmugiah, Vijaya Mahalingam; Bakar, Rula Bany; Yankova, Eliza; Cooper, Jonathan L.; Narayan, Nisha; Horton, Sarah J.; Asby, Ryan; Pask, Dean C.; Mupo, Annalisa; Duddy, Graham; Marando, Ludovica; Georgomanolis, Theodoros; Carter, Paul; Ramesh, Amirtha Priya; Dunn, William G.; Barcena, Clea; Gallipoli, Paolo; Yusa, Kosuke; Petrovski, Slave; Wright, Penny; Quiros, Pedro M.; Frezza, Christian; Nathan, James A.; Kaser, Arthur; Kar, Siddhartha; Tzelepis, Konstantinos; Mitchell, Jonathan; Fabre, Margarete A.; Huntly, Brian J. P.; Vassiliou, George S.
作者单位：University of Cambridge; University of Cambridge; AstraZeneca; University of Cambridge; University of Cambridge; Francis Crick Institute; University of Cologne; University of Cambridge; University of Oviedo; Instituto Universitario de Oncologia de Asturias; University of London; Queen Mary University London; Kyoto University; Canterbury Health Laboratories; University of Cologne; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; Wellcome Trust Sanger Institute
摘要：Somatic DNMT3A-R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To identify DNMT3A-R882-mutant-specific vulnerabilities, we conducted a genome-wide CRISPR screen on primary mouse Dnmt3aR882H/+ HSPCs. Among the 640 vulnerability genes identified, many were involved in ...
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作者：Robinson, Andrew
