-
作者：Barbarino, Paola
-
作者：Burrello, Michele
作者单位：University of Pisa
-
作者：Shao, Ling-Xiao; Liao, Clara; Davoudian, Pasha A.; Savalia, Neil K.; Jiang, Quan; Wojtasiewicz, Cassandra; Tan, Diran; Nothnagel, Jack D.; Liu, Rong-Jian; Woodburn, Samuel C.; Bilash, Olesia M.; Kim, Hail; Che, Alicia; Kwan, Alex C.
作者单位：Cornell University; Yale University; Yale University; Yale University; Korea Advanced Institute of Science & Technology (KAIST); Cornell University; Weill Cornell Medicine
摘要：Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses1, 2, 3-4. At the cellular level, psychedelics induce structural neural plasticity5,6, exemplified by the drug-evoked growth and remodelling of dendritic spines in cortical pyramidal cells7, 8-9. A key question is how these cellular modifications map onto cell-type-specific circuits to produce the psychedelics' behavioural actions10. Here we use in vivo optical imaging, chemogenetic perturbation an...
-
作者：Dafermos, Mihalis
作者单位：University of Cambridge
-
作者：Wen, Chengqian; Xu, Xintao; Guo, Huiping
作者单位：Qingdao University of Technology
-
作者：[Anonymous]
-
作者：Earl, Alexis D.; Carter, Gerald G.; Berlinger, Arden G.; Korir, Elkana; Shah, Shailee S.; Watetu, Wilson N.; Rubenstein, Dustin R.
作者单位：Columbia University; Princeton University; Smithsonian Institution; Smithsonian Tropical Research Institute; Howard Hughes Medical Institute; Cornell University; University of Cambridge; Cornell University
摘要：Identifying the mechanisms that underlie cooperation is fundamental to biology1. The most complex form of cooperation in vertebrates occurs in cooperative breeders, in which helpers forego reproduction and assist in raising the young of others, typically relatives2. Not all cooperative societies, however, are kin-based-nearly half of all avian3 and mammalian4 cooperative breeders form mixed-kin societies, much like those of humans5. Kin selection in mixed-kin societies occurs when individuals ...
-
作者：Hosseini, Amir; Dhall, Abhinav; Ikonen, Nemo; Sikora, Natalia; Nguyen, Sylvain; Shen, Yuqi; Amaral, Maria Luisa Jurgensen; Jiao, Alan; Wallner, Felice; Sergeev, Philipp; Lim, Yuhua; Yang, Yuanqin; Vick, Binje; Kawabata, Kimihito Cojin; Melnick, Ari; Vyas, Paresh; Ren, Bing; Jeremias, Irmela; Psaila, Bethan; Heckman, Caroline A.; Blanco, M. Andres; Shi, Yang
作者单位：Ludwig Institute for Cancer Research; University of Oxford; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Helsinki; University of Oxford; University of California System; University of California San Diego; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Helmholtz Association; German Cancer Research Center (DKFZ); Cornell University; Weill Cornell Medicine; Oxford University Hospitals NHS Foundation Trust; University of Munich; University of Pennsylvania
摘要：Impaired differentiation is a hallmark of myeloid malignancies1,2. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia3, but whether 'differentiation therapy' is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely understood. Here we demonstrate that simultaneous inhibition of the histone demethylase LS...
-
作者：Kwon, Diana
-
作者：Lange, Mike; Olzmann, James A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
