2025

最新文章

• Fetal and parental genomes offer mechanistic insights into pregnancy loss AI翻译
  作者：Gao, Ziyue
  作者单位：University of Pennsylvania
  摘要：Genomic analyses of mother-father-fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants.
• Tighter regulation is needed for AI companions AI翻译
  作者：Zhang, Lili; Wang, Haomiaomiao; Cheng, Long; Fang, Fang
  作者单位：Dublin City University; North China Electric Power University
• Skyrocketing mpox outbreak in Sierra Leone raises fears of wider spread AI翻译
  作者：Kozlov, Max
• Authorship for sale: Nature investigates how paper mills work AI翻译
  作者：Ro, Christine; Leeming, Jack
• Metal-support frontier orbital interactions in single-atom catalysis (vol 640, pg 668, 2025) AI翻译
  作者：Shi, Xianxian; Wen, Zhilin; Gu, Qingqing; Jiao, Long; Jiang, Hai-Long; Lv, Haifeng; Wang, Hengwei; Ding, Jiani; Lyons, Mason P.; Chang, Alvin; Feng, Zhenxing; Chen, Si; Lin, Yue; Xu, Xiaoyan; Du, Pengfei; Xu, Wenlong; Sun, Mei; Li, Yin; Yang, Bing; Zhang, Tao; Wu, Xiaojun; Lu, Junling
• Plant diversity dynamics over space and time in a warming Arctic AI翻译
  作者：Garcia Criado, Mariana; Myers-Smith, Isla H.; Bjorkman, Anne D.; Elmendorf, Sarah C.; Normand, Signe; Aastrup, Peter; Aerts, Rien; Alatalo, Juha M.; Baeten, Lander; Bjork, Robert G.; Bjorkman, Mats P.; Boulanger-Lapointe, Noemie; Butler, Ethan E.; Cooper, Elisabeth J.; Cornelissen, J. Hans C.; Daskalova, Gergana N.; Fadrique, Belen; Forbes, Bruce C.; Henry, Greg H. R.; Hollister, Robert D.; Hoye, Toke Thomas; Jacobsen, Ida Bomholt Dyrholm; Jagerbrand, Annika K.; Jonsdottir, Ingibjoerg S.; Kaarlejarvi, Elina; Khitun, Olga; Klanderud, Kari; Kolari, Tiina H. M.; Lang, Simone I.; Lecomte, Nicolas; Lenoir, Jonathan; Macek, Petr; Messier, Julie; Michelsen, Anders; Molau, Ulf; Muscarella, Robert; Nielsen, Marie-Louise; Petit Bon, Matteo; Post, Eric; Raundrup, Katrine; Rinnan, Riikka; Rixen, Christian; Ryde, Ingvild; Serra-Diaz, Josep M.; Schaepman-Strub, Gabriela; Schmidt, Niels M.; Schrodt, Franziska; Sjogersten, Sofie; Steinbauer, Manuel J.; Stewart, Laerke; Strandberg, Beate; Tolvanen, Anne; Tweedie, Craig E.; Vellend, Mark
  作者单位：University of Edinburgh; University of British Columbia; University of Gothenburg; University of Gothenburg; University of Colorado System; University of Colorado Boulder; Aarhus University; Aarhus University; Aarhus University; Qatar University; Ghent University; University of Gothenburg; University of Victoria; University of Minnesota System; University of Minnesota Twin Cities; UiT The Arctic University of Tromso; International Institute for Applied Systems Analysis (IIASA); University of Leeds; University of Liverpool; University of Lapland; University of British Columbia; Grand Valley State University; Aarhus University; Greenland Institute of Natural Resources; University of Gavle; University of Iceland; University of Helsinki; Norwegian University of Life Sciences; University of Eastern Finland; University of Quebec; University of Quebec Montreal; University Centre Svalbard (UNIS); University of Moncton; Universite de Picardie Jules Verne (UPJV); Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Estonian University of Life Sciences; University of Waterloo; University of Copenhagen; Uppsala University; Utah System of Higher Education; Utah State University; University of California System; University of California Davis; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; AgroParisTech; INRAE; Universite de Lorraine; University of Zurich; University of Nottingham; University of Nottingham; University of Bayreuth; University of Bayreuth; University of South-Eastern Norway; Natural Resources Institute Finland (Luke); University of Texas System; University of Texas El Paso; University of Sherbrooke
  摘要：The Arctic is warming four times faster than the global average1 and plant communities are responding through shifts in species abundance, composition and distribution2, 3-4. However, the direction and magnitude of local changes in plant diversity in the Arctic have not been quantified. Using a compilation of 42,234 records of 490 vascular plant species from 2,174 plots across the Arctic, here we quantified temporal changes in species richness and composition through repeat surveys between 198...
• PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease AI翻译
  作者：Nyame, Kwamina; Xiong, Jian; Alsohybe, Hisham N.; de Jong, Arthur P. H.; Pena, Isabelle V.; de Miguel, Ricardo; Brummelkamp, Thijn R.; Hartmann, Guido; Nijman, Sebastian M. B.; Raaben, Matthijs; Simcox, Judith A.; Blomen, Vincent A.; Abu-Remaileh, Monther
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Netherlands Cancer Institute; Howard Hughes Medical Institute; University of Wisconsin System; University of Wisconsin Madison; Stanford University
  摘要：Lysosomes catabolize lipids and other biological molecules, maintaining cellular and organismal homeostasis. Bis(monoacylglycero)phosphate (BMP), a major lipid constituent of intralysosomal vesicles, stimulates lipid-degrading enzymes and is altered in various human conditions, including neurodegenerative diseases1,2. Although lysosomal BMP synthase was recently discovered3, the enzymes mediating BMP turnover remain elusive. Here we show that lysosomal phospholipase PLA2G15 is a physiological ...
• Towards accurate differential diagnosis with large language models AI翻译
  作者：McDuff, Daniel; Schaekermann, Mike; Tu, Tao; Palepu, Anil; Wang, Amy; Garrison, Jake; Singhal, Karan; Sharma, Yash; Azizi, Shekoofeh; Kulkarni, Kavita; Hou, Le; Cheng, Yong; Liu, Yun; Mahdavi, S. Sara; Prakash, Sushant; Pathak, Anupam; Semturs, Christopher; Patel, Shwetak; Webster, Dale R.; Dominowska, Ewa; Gottweis, Juraj; Barral, Joelle; Chou, Katherine; Corrado, Greg S.; Matias, Yossi; Sunshine, Jake; Karthikesalingam, Alan; Natarajan, Vivek
  作者单位：Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind; Alphabet Inc.; DeepMind; Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind; Alphabet Inc.; Google Incorporated
  摘要：A comprehensive differential diagnosis is a cornerstone of medical care that is often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by large language models present new opportunities to assist and automate aspects of this process1. Here we introduce the Articulate Medical Intelligence Explorer (AMIE), a large language model that is optimized for diagnostic reasoning, and...
• Making slabs and sleepers from old appliances AI翻译
  作者：Noronha, Patricia Maia
• Activation of lysosomal iron triggers ferroptosis in cancer AI翻译
  作者：Caneque, Tatiana; Baron, Leeroy; Mueller, Sebastian; Carmona, Alanis; Colombeau, Ludovic; Versini, Antoine; Solier, Stephanie; Gaillet, Christine; Sindikubwabo, Fabien; Sampaio, Julio L.; Sabatier, Marie; Mishima, Eikan; Picard-Bernes, Armel; Syx, Laurene; Servant, Nicolas; Lombard, Berangere; Loew, Damarys; Zheng, Jiashuo; Proneth, Bettina; Thoidingjam, Leishemba K.; Grimaud, Laurence; Fraser, Cameron S.; Szylo, Krystina J.; Kazarian, Emma Der; Bonnet, Caroline; Charafe-Jauffret, Emmanuelle; Ginestier, Christophe; Santofimia-Castano, Patricia; Estaras, Matias; Dusetti, Nelson; Iovanna, Juan Lucio; Cunha, Antonio Sa; Pittau, Gabriella; Hammel, Pascal; Tzanis, Dimitri; Bonvalot, Sylvie; Watson, Sarah; Gandon, Vincent; Upadhyay, Aditya; Pratt, Derek A.; Freitas, Florencio Porto; Angeli, Jose Pedro Friedmann; Stockwell, Brent R.; Conrad, Marcus; Ubellacker, Jessalyn M.; Rodriguez, Raphael
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Harvard University; Harvard T.H. Chan School of Public Health; UNICANCER; Universite PSL; Institut Curie; Universite Paris Saclay; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; UNICANCER; Universite PSL; Institut Curie; MINES ParisTech; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Institut Paoli-Calmette (IPC); Centre National de la Recherche Scientifique (CNRS); UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite; Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP; UNICANCER; Universite PSL; Institut Curie; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of Ottawa; University of Wurzburg; Columbia University; Columbia University; Columbia University; Technical University of Munich
  摘要：Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic approaches have revealed suppressors of ferroptosis2, 3-4; by contrast, small molecules can provide spatiotemporal control of the chemistry at work5. Here we show that the ferroptosis inhibitor liproxstatin-1...