作者：Ghosh, Subir; Zheng, Yikai; Rafiq, Musaib; Ravichandran, Harikrishnan; Sun, Yongwen; Chen, Chen; Goswami, Mrinmoy; Sakib, Najam U.; Sadaf, Muhtasim Ul Karim; Pannone, Andrew; Ray, Samriddha; Redwing, Joan M.; Yang, Yang; Sahay, Shubham; Das, Saptarshi
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Jadavpur University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Silicon has enabled advancements in semiconductor technology through miniaturization, but scaling challenges necessitate the exploration of new materials1. Two-dimensional (2D) materials, with their atomic thickness and high carrier mobility, offer a promising alternative2, 3, 4-5. Although significant progress has been made in wafer-scale growth6, 7-8, high-performance field-effect transistors9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19-20 and circuits based on 2D materials21, 22-23, achieving c...
作者：Kornfeld, Joergen M. R.
作者单位：MRC Laboratory Molecular Biology
作者：Eickhoff, Patrik; Sonmez, Ceylan; Fisher, Charlotte E. L.; Inian, Oviya; Roumeliotis, Theodoros I.; dello Stritto, Angela; Mansfeld, Joerg; Choudhary, Jyoti S.; Guettler, Sebastian; Lottersberger, Francisca; Douglas, Max E.
作者：Sabonis, Dziugas; Avraham, Carmel; Chang, Renee B.; Lu, Allen; Herbst, Ehud; Silanskas, Arunas; Vilutis, Deividas; Leavitt, Azita; Yirmiya, Erez; Toyoda, Hunter C.; Ruksenaite, Audrone; Zaremba, Mindaugas; Osterman, Ilya; Amitai, Gil; Kranzusch, Philip J.; Sorek, Rotem; Tamulaitiene, Giedre
作者单位：Vilnius University; Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Toll/interleukin-1 receptor (TIR) domains are central components of pattern recognition immune proteins across all domains of life1,2. In bacteria and plants, TIR-domain proteins recognize pathogen invasion and then produce immune signalling molecules exclusively comprising nucleotide moieties2, 3, 4-5. Here we show that the TIR-domain protein of the type II Thoeris defence system in bacteria produces a unique signalling molecule comprising the amino acid histidine conjugated to ADP-ribose (Hi...
