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作者：Larsen, M. V.; Bourassa, J. E.; Kocsis, S.; Tasker, J. F.; Chadwick, R. S.; Gonzalez-Arciniegas, C.; Hastrup, J.; Lopetegui-Gonzalez, C. E.; Miatto, F. M.; Motamedi, A.; Noro, R.; Roeland, G.; Baby, R.; Chen, H.; Contu, P.; Di Luch, I.; Drago, C.; Giesbrecht, M.; Grainge, T.; Krasnokutska, I.; Menotti, M.; Morrison, B.; Puviraj, C.; Rezaei Shad, K.; Hussain, B.; McMahon, J.; Ortmann, J. E.; Collins, M. J.; Ma, C.; Phillips, D. S.; Seymour, M.; Tang, Q. Y.; Yang, B.; Vernon, Z.; Alexander, R. N.; Mahler, D. H.
摘要：Building a useful photonic quantum computer requires robust techniques to synthesize optical states that can encode qubits. Gottesman-Kitaev-Preskill (GKP) states1 offer one of the most attractive classes of such qubit encodings, as they enable the implementation of universal gate sets with straightforward, deterministic and room temperature-compatible Gaussian operations2. Existing pioneering demonstrations generating optical GKP states3 and other complex non-Gaussian states4, 5, 6, 7, 8, 9, ...
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作者：Wang, Ningning; Ji, Weiwei; Jiao, Houqi; Veit, Michael; Sun, Ju; Wang, Yanjun; Ma, Xing; Wang, Yu; Wang, Yutong; Li, Xin-xin; Zhang, Xiaoguang; Chen, Jie; Wei, Jiayu; Xu, Ying; Guo, Dawei; Zhai, Xiaofeng; Merits, Andres; Li, Chang; Rey, Felix A.; Dobrikov, Georgi M.; Gao, George F.; Zhang, Shuijun; Bi, Yuhai; Su, Shuo
作者单位：Nanjing Agricultural University; Nanjing Agricultural University; Nanjing Agricultural University; Free University of Berlin; Chinese Academy of Sciences; University of Tartu; Chinese Academy of Medical Sciences - Peking Union Medical College; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Bulgarian Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Jinzhou Medical University; Fudan University
摘要：Despite accumulating evidence that bat-derived coronaviruses often require intermediate hosts to facilitate transmission to humans1, the potential role of fur animals in zoonotic coronavirus spillovers has largely been overlooked2. Here we report the isolation and characterization of a previously undescribed mink respiratory coronavirus (MRCoV) from farmed minks with pneumonia. Notably, MRCoV uses angiotensin-converting enzyme 2 (ACE2) as an entry receptor and can infect mink, bat, monkey and ...
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作者：Panagopoulos, Andreas; Stout, Merula; Kilic, Sinan; Leary, Peter; Vornberger, Julia; Pasti, Virginia; Galarreta, Antonio; Lezaja, Aleksandra; Kirschenbuehler, Kyra; Imhof, Ralph; Rehrauer, Hubert; Ziegler, Urs; Altmeyer, Matthias
作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of Zurich; University of Copenhagen
摘要：Cell heterogeneity is a universal feature of life. Although biological processes affected by cell-to-cell variation are manifold, from developmental plasticity to tumour heterogeneity and differential drug responses, the sources of cell heterogeneity remain largely unclear1,2. Mutational and epigenetic signatures from cancer (epi)genomics are powerful for deducing processes that shaped cancer genome evolution3, 4-5. However, retrospective analyses face difficulties in resolving how cellular he...
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作者：Cho, Sangkyun; Rhee, Siyeon; Madl, Christopher M.; Caudal, Arianne; Thomas, Dilip; Kim, Hyeonyu; Kojic, Ana; Shin, Hye Sook; Mahajan, Abhay; Jahng, James W.; Wang, Xi; Thai, Phung N.; Paik, David T.; Wang, Mingqiang; Mullen, Mckay; Baker, Natalie M.; Leitz, Jeremy; Mukherjee, Souhrid; Winn, Virginia D.; Woo, Y. Joseph; Blau, Helen M.; Wu, Joseph C.
作者单位：Stanford University; Stanford University; Stanford University; University of Pennsylvania; University System of Ohio; Ohio State University; University of California System; University of California Davis; Stanford University; Stanford University
摘要：Matrix-derived biophysical cues are known to regulate the activation of fibroblasts and their subsequent transdifferentiation into myofibroblasts(1, 2, 3, 4, 5-6), but whether modulation of these signals can suppress fibrosis in intact tissues remains unclear, particularly in the cardiovascular system(7, 8, 9-10). Here we demonstrate across multiple scales that inhibition of matrix mechanosensing in persistently activated cardiac fibroblasts potentiates-in concert with soluble regulators of th...
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作者：Aksenfeld, Rita
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作者：Savitsky, Zack
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作者：Cheng, Caleb; Hu, Jing; Mannan, Rahul; He, Tongchen; Bhattacharyya, Rupam; Magnuson, Brian; Wisniewski, Jasmine P.; Peters, Sydney; Karim, Saadia A.; MacLean, David J.; Karaburk, Huseyin; Zhang, Li; Rossiter, Nicholas J.; Zheng, Yang; Xiao, Lanbo; Li, Chungen; Awad, Dominik; Mahapatra, Somnath; Bao, Yi; Zhang, Yuping; Cao, Xuhong; Wang, Zhen; Mehra, Rohit; Morlacchi, Pietro; Sahai, Vaibhav; di Magliano, Marina Pasca; Shah, Yatrik M.; Weisman, Lois S.; Morton, Jennifer P.; Ding, Ke; Qiao, Yuanyuan; Lyssiotis, Costas A.; Chinnaiyan, Arul M.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Shandong University; Central South University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Michigan System; University of Michigan; Howard Hughes Medical Institute; Agilent Technologies; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Glasgow; University of Michigan System; University of Michigan
摘要：Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism1,2. For example, PDAC uses, and is dependent on, high levels of autophagy and other lysosomal processes3, 4-5. Although targeting these pathways has shown potential in preclinical studies, progress has been hampered by the difficulty in identifying and characterizing favourable targets for drug development6. Here, we...
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作者：Lobel, Joseph H.; Ingolia, Nicholas T.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Intrinsically disordered regions within proteins drive specific molecular functions despite lacking a defined structure1,2. Although disordered regions are integral to controlling mRNA stability and translation, the mechanisms underlying these regulatory effects remain unclear3. Here we reveal the molecular determinants of this activity using high-throughput functional profiling. Systematic mutagenesis across hundreds of regulatory disordered elements, combined with machine learning, reveals a...
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作者：Eisenstein, Michael
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作者：Nunes, Ashley
作者单位：Harvard University
