2025

最新文章

• Trump team disbands controversial US climate panel AI翻译
  作者：Tollefson, Jeff
• Years of hits to the head prime the brain for decline AI翻译
  作者：Bachstetter, Adam; Morganti, Josh
  作者单位：University of Kentucky; University of Kentucky; University of Kentucky
• Stabilizing effect of amino acids on protein and colloidal dispersions AI翻译
  作者：Mao, Ting; Xu, Xufeng; Winkler, Pamina M.; Siri, Cecilia; Poliukhina, Ekaterina; Silva, Paulo Jacob; Xu, Nan; Hu, Yu; Al Zahabi, Karim; La Polla, Remi; Luo, Zhi; Ong, Quy; Alexander-Katz, Alfredo; Stellacci, Francesco
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Southern University of Science & Technology; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Amino acids (AAs) have a long history of being used as stabilizers for biological media1. For example, they are important components in biomedical formulations. The effect of AAs on biological systems is also starting to be appreciated. For example, it is believed that water-stressed cells increase the levels of AAs to prevent protein aggregation2. Several hypotheses have been put forward regarding their function, ranging from water-structuring3 to hydrotropic4 to specific effects such as stab...
• Long-range PM2.5 pollution and health impacts from the 2023 Canadian wildfires AI翻译
  作者：Zhang, Qiang; Wang, Yuexuanzi; Xiao, Qingyang; Geng, Guannan; Davis, Steven J.; Liu, Xiaodong; Yang, Jin; Liu, Jiajun; Huang, Wenyu; He, Changpei; Luo, Binhe; Martin, Randall V.; Brauer, Michael; Randerson, James T.; He, Kebin
  作者单位：Tsinghua University; Tsinghua University; Stanford University; Beijing Normal University; Washington University (WUSTL); University of British Columbia; University of Washington; Institute for Health Metrics & Evaluation; University of Washington Seattle; University of California System; University of California Irvine
  摘要：Smoke from extreme wildfires in Canada adversely affected air quality in many regions in 20231,2. Here we use satellite observations, machine learning and a chemical transport model to quantify global and regional PM2.5 (particulate matter less than 2.5 mu m in diameter) exposure and human health impacts related to the 2023 Canadian wildfires. We find that the fires increased annual PM2.5 exposure worldwide by 0.17 mu g m-3 (95% confidence interval, 0.09-0.26 mu g m-3). North America had the l...
• Analog optical computer for AI inference and combinatorial optimization AI翻译
  作者：Kalinin, Kirill P.; Gladrow, Jannes; Chu, Jiaqi; Clegg, James H.; Cletheroe, Daniel; Kelly, Douglas J.; Rahmani, Babak; Brennan, Grace; Canakci, Burcu; Falck, Fabian; Hansen, Michael; Kleewein, Jim; Kremer, Heiner; O'Shea, Greg; Pickup, Lucinda; Rajmohan, Saravan; Rowstron, Ant; Ruhle, Victor; Braine, Lee; Khedekar, Shrirang; Berloff, Natalia G.; Gkantsidis, Christos; Parmigiani, Francesca; Ballani, Hitesh
  作者单位：Microsoft; Microsoft United Kingdom; Microsoft; University of Cambridge
  摘要：Artificial intelligence (AI) and combinatorial optimization drive applications across science and industry, but their increasing energy demands challenge the sustainability of digital computing. Most unconventional computing systems(1-7) target either AI or optimization workloads and rely on frequent, energy-intensive digital conversions, limiting efficiency. These systems also face application-hardware mismatches, whether handling memory-bottlenecked neural models, mapping real-world optimiza...
• USING BIOBANKS TO BOOST RESEARCH: A HOW-TO GUIDE AI翻译
  作者：Madhusoodanan, Jyoti
  摘要：From large national databases to bespoke sample collections, biobanks offer a wealth of avenues for scientific enquiry.
• A closer look at how cells sense dietary nutrients AI翻译
  作者：Linde-Garelli, Karen Y.; Rogala, Kacper B.
  作者单位：Stanford University; Stanford Medicine
• How changes in behaviour can save lives in disasters AI翻译
  作者：Kuriyama, Shinichi
  作者单位：Tohoku University
• Axonal injury is a targetable driver of glioblastoma progression AI翻译
  作者：Clements, Melanie; Tang, Wenhao; Florjanic Baronik, Zan; Simpson Ragdale, Holly; Oria, Roger; Volteras, Dimitrios; White, Ian J.; Beattie, Gordon; Uddin, Imran; Lenn, Tchern; Lindsay, Rachel; Castro Devesa, Sara; Karamched, Saketh R.; Lythgoe, Mark F.; Shahrezaei, Vahid; Weaver, Valerie M.; Sugisawa, Ryoichi; Roncaroli, Federico; Marguerat, Samuel; Hill, Ciaran S.; Parrinello, Simona
  作者单位：University of London; University College London; Imperial College London; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of California System; University of California San Francisco; Kindai University (Kinki University); University of Manchester; University College London Hospitals NHS Foundation Trust; University of London; National Hospital for Neurology & Neurosurgery; University College London; UCL Medical School
  摘要：Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour1,2. Although advanced disease has been intensely investigated, the mechanisms that underpin the earlier, likely more tractable, stages of GBM development remain poorly understood. Here we identify axonal injury as a key driver of GBM progression, which we find is induced in white matter by early tumour cells preferentially expanding in this region. Mechanistically, axonal injury promotes gliomagenesis by triggering W...
• TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function AI翻译
  作者：Shen, Qian; Wang, Hao; Roco, Jonathan A.; Meng, Xiangpeng; Bosticardo, Marita; Hodges, Marie; Battaglia, Michael; Feng, Zhi-Ping; Talks, Benjamin James; Powell, Jason; Shanmugiah, Vijaya Baskar Mahalingam; Chu, Julia; Rahman, Najib M.; Elsheikh, Alguili; Chakravarty, Probir; Grenov, Amalie; Emmerich, Max; Delmonte, Ottavia M.; Freeman, Alexandra F.; Keller, Michael D.; Belaid, Brahim; Papa, Ilenia; Lee, James C.; Canete, Pablo F.; Gonzalez-Figueroa, Paula; Zhang, Yaoyuan; Xue, Hai-Hui; Turajlic, Samra; Notarangelo, Luigi D.; Haniffa, Muzlifah; Garrett-Sinha, Lee Ann; Parry, Helen M.; Kanellakis, Nikolaos I.; Vinuesa, Carola G.
  作者单位：Francis Crick Institute; Australian National University; John Curtin School of Medical Research; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Birmingham; State University of New York (SUNY) System; University at Buffalo, SUNY; Australian National University; John Curtin School of Medical Research; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Wellcome Trust Sanger Institute; University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Royal Marsden NHS Foundation Trust; Children's National Health System; University of Queensland; University of Queensland; Hackensack University Medical Center
  摘要：B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial1, 2-3. The CD5+ B-1a subset expresses anti-inflammatory molecules including IL-10, PDL1 and CTLA4 and can be immunoregulatory4, 5-6. Unlike conventional B cells that are continuously replenished, B-1a cells are produced early in life and maintained through self-renewal7. Here we show that the transcription factors TCF1 and L...