2025

最新文章

• Blocking a key node in cancer signalling unlocks therapeutic potential AI翻译
  作者：Lavoie, Hugo; Therrien, Marc
  作者单位：Universite de Montreal
• Stress dynamically modulates neuronal autophagy to gate depression onset (vol 641, pg 427, 2025) AI翻译
  作者：Yang, Liang; Guo, Chen; Zheng, Zhiwei; Dong, Yiyan; Xie, Qifeng; Lv, Zijian; Li, Min; Lu, Yangyang; Guo, Xiaonan; Deng, Rongshan; Liu, Yiqin; Feng, Yirong; Mu, Ruiqi; Zhang, Xuliang; Ma, Huan; Chen, Zhong; Zhang, Zhijun; Dong, Zhaoqi; Yang, Wei; Zhang, Xiangnan; Cui, Yihui
• Inflammatory bowel disease has stages of epidemiology that can be tracked across global regions AI翻译
  作者：Kaplan, Gilaad G.; Ng, SiewC.
  作者单位：University of Calgary; Chinese University of Hong Kong
  摘要：The spatio-temporal evolution of inflammatory bowel disease across the world follows four epidemiological stages: emergence, acceleration in incidence, compounding prevalence and prevalence equilibrium. Classifying regions by epidemiological stage enables health-care systems to prepare for the evolving global burden.
• Regulation of PV interneuron plasticity by neuropeptide-encoding genes AI翻译
  作者：Selten, Martijn; Bernard, Clemence; Mukherjee, Diptendu; Hamid, Fursham; Hanusz-Godoy, Alicia; Oozeer, Fazal; Zimmer, Christoph; Marin, Oscar
  作者单位：University of London; King's College London; University of London; King's College London; University of Exeter
  摘要：Neuronal activity must be regulated in a narrow permissive band for the proper operation of neural networks. Changes in synaptic connectivity and network activity-for example, during learning-might disturb this balance, eliciting compensatory mechanisms to maintain network function1, 2-3. In the neocortex, excitatory pyramidal cells and inhibitory interneurons exhibit robust forms of stabilizing plasticity. However, although neuronal plasticity has been thoroughly studied in pyramidal cells4, ...
• First global pandemic treaty agreed - without the US AI翻译
  作者：Biever, Celeste
• Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis AI翻译
  作者：Jia, Shidong; Liu, Zhenning; Zhang, Sen; Liu, Pixu; Zhang, Lei; Lee, Sang Hyun; Zhang, Jing; Signoretti, Sabina; Loda, Massimo; Roberts, Thomas M.; Zhao, Jean J.
• Scientists must regain trust AI翻译
  作者：De Keersmaecker, Jonas; Van Bavel, Jay J.
  作者单位：IE University; New York University
• High time to tackle drug-resistant fungal infections AI翻译
  作者：[Anonymous]
• Phase I trial of hES cell-derived dopaminergic neurons for Parkinson's disease AI翻译
  作者：Tabar, V.; Sarva, H.; Lozano, A. M.; Fasano, A.; Kalia, S. K.; Yu, K. K. H.; Brennan, C.; Ma, Y.; Peng, S.; Eidelberg, D.; Tomishima, M.; Irion, S.; Stemple, W.; Abid, N.; Lampron, A.; Studer, L.; Henchcliffe, C.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Toronto; Krembil Research Institute; University of Toronto; University of Toronto; University Health Network Toronto; Northwell Health; Northwell Health; Memorial Sloan Kettering Cancer Center; University of California System; University of California Irvine
  摘要：Parkinson's disease is a progressive neurodegenerative condition with a considerable health and economic burden1. It is characterized by the loss of midbrain dopaminergic neurons and a diminished response to symptomatic medical or surgical therapy as the disease progresses2. Cell therapy aims to replenish lost dopaminergic neurons and their striatal projections by intrastriatal grafting. Here, we report the results of an open-label phase I clinical trial (NCT04802733) of an investigational cry...
• Science's big problem is a loss of influence, not a loss of trust AI翻译
  作者：Larson, Heidi J.; Bersoff, David M.
  作者单位：University of London; London School of Hygiene & Tropical Medicine; Institute for Health Metrics & Evaluation; University of Washington; University of Washington Seattle